Special Issue "Therapeutic Potentials of Secondary Metabolites from Plants, Microbes and Endophytes"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".

Deadline for manuscript submissions: 20 June 2023 | Viewed by 226

Special Issue Editors

Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
Interests: natural products chemistry
Dr. Dalia El Amir Mohamed
E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
Interests: natural products chemistry
Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
Interests: natural products chemistry

Special Issue Information

Dear Colleagues,

Natural products derived from microbes and endophytes have diverse pharmacological effects with antibiotic, antidiabetic, antiviral, and antitumor activities. These bioactive compounds are commonly used in foods, cosmetics, and nursing products. Medicinal plants and fungi represent the main source for bioactive natural products. However, the extraction of such compounds from plants and fungi is time-consuming and costly due to structural complexity, low product concentration, and the lengthy plantation period. Microbes as well as endophytes have been recognized as potential sources for the discovery of novel natural products for exploitation in medicine, agriculture, and industry. It is noteworthy that among all plant species that exist on Earth, each individual plant hosts at least one endophyte. They are the chemical synthesizers inside plants; they synthesize bioactive compounds that can be used by plants for defense against pathogens, and some of these compounds have been proven useful for novel drug discovery. Recent studies have reported hundreds of natural products including alkaloids, terpenoids, flavonoids, steroids, and others from endophytes and microbes.

This Special Issue aims to cover promising, recent, and novel research trends in studying endophytes and microbes as a source for bioactive metabolites. This issue may also cover but is not limited to the following topics:

  • Discovery of genes involved in the biosynthetic pathway of natural products in endophytes and microbes.
  • Metabolomic study of microbes’ and endophytes’ metabolites.
  • Assessment of the biological activity of natural products obtained from natural sources.
  • Isolation and functional research of natural products from plants, endophytes, and microbes.
  • Drug discovery and in silico studies against different biological conditions.

Prof. Dr. Rabab Mohammed
Dr. Dalia El Amir Mohamed
Dr. Marwa Hassan Ahmed Hassan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.



  • secondary metabolites
  • endophytes
  • microbes
  • alkaloids
  • phenolic compounds
  • metabolomics
  • biosynthesis

Published Papers

This special issue is now open for submission.
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