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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Table of Contents

Sci. Pharm., Volume 78, Issue 3 (September 2010) – 203 articles , Pages 397-744

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Open AccessEditorial
Scientia Pharmaceutica, Autorenhinweise 2010
Sci. Pharm. 2010, 78(3), 731-744; https://doi.org/10.3797/scipharm.aut-10-03 - 12 Jul 2010
Viewed by 424
Abstract
Die Zeitschrift Scientia Pharmaceutica (www.scipharm.at) erscheint vierteljährlich jeweils am Quartalsende und ist ein Medium zur Publikation von Originalarbeiten, Kurzmit-teilungen und ausgewählten Übersichtsarbeiten aus allen wissenschaftlichen Disziplinen der Pharmazie und angrenzenden Gebieten sowie der pharmazeutischen Praxis. [...]
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Open AccessBook Review
"Mikroskopischer Farbatlas pflanzlicher Drogen"
Sci. Pharm. 2010, 78(3), 730; https://doi.org/10.3797/scipharm.br-10-04 - 12 Jul 2010
Viewed by 424
Open AccessBook Review
"Classics in Spectroscopy"
Sci. Pharm. 2010, 78(3), 729; https://doi.org/10.3797/scipharm.br-10-03 - 12 Jul 2010
Viewed by 432
Open AccessConference Report
Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter
Sci. Pharm. 2010, 78(3), 727-728; https://doi.org/10.3797/scipharm.cespt.8.POT12 - 12 Jul 2010
Viewed by 408
Abstract
A mathematical model has been developed describing the pharmacokinetics of Hoechst 33342 following administration into a culture medium containing a population of transfected cells (HEK293 hBCRP) with a potent inhibitor of the BCRP, Fumitremorgin C (FTC), present. [...]
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Open AccessConference Report
P-gp Inhibitory Potential of Phospholipids
Sci. Pharm. 2010, 78(3), 726; https://doi.org/10.3797/scipharm.cespt.8.POT11 - 12 Jul 2010
Viewed by 443
Abstract
Introduction: Oral drug administration is mainly regulated by the step of intestinal absorption. [...]
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Open AccessConference Report
Impact of Heat Stress on the Cellular Activity and Culturability of Probiotic Microorganisms
Sci. Pharm. 2010, 78(3), 725; https://doi.org/10.3797/scipharm.cespt.8.POT10 - 12 Jul 2010
Viewed by 423
Abstract
The essential manufacturing step of probiotic products involves dehydration of microorganisms, resulting in cellular stabilization and improved formulation and storage characteristics. [...]
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Open AccessConference Report
Density Functional Theory Calculations on Methylated β-Cyclodextrins
Sci. Pharm. 2010, 78(3), 724; https://doi.org/10.3797/scipharm.cespt.8.POT09 - 12 Jul 2010
Viewed by 387
Abstract
Density functional theory studies at the B3LYP/6-31G(d,p) and M06-2X/6- 31G(d,p) levels have been used to determine the geometries and the enthalpies of formation of several methylated β-cyclodextrins. [...]
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Open AccessConference Report
Interactions Of Different Sartans with the Bilayer Interface Studied by Saxs
Sci. Pharm. 2010, 78(3), 723; https://doi.org/10.3797/scipharm.cespt.8.POT08 - 12 Jul 2010
Viewed by 408
Abstract
This work presents a thorough investigation of the interaction of the novel synthetic pyrrolidinone analog MMK3 and other SARTANS (losartan, valsartan and candesartan) with the model membrane system of dipalmitoylphosphatidylcholine (DPPC). [...]
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Open AccessConference Report
Defining Carbohydrate Targets on Osteoarthritic Chondrocytes using RT-qPCR and LC-ESI-MS
Sci. Pharm. 2010, 78(3), 722; https://doi.org/10.3797/scipharm.cespt.8.POT07 - 12 Jul 2010
Viewed by 391
Abstract
Multiple carbohydrate structures in the chondrocyte glycocalyx can serve as targets for biorecognitive lectins. [...]
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Open AccessConference Report
Modern Dressings for Wound Healing
Sci. Pharm. 2010, 78(3), 721; https://doi.org/10.3797/scipharm.cespt.8.POT06 - 12 Jul 2010
Viewed by 414
Abstract
Aim: Wound healing is a complex process with many potential factors that can delay healing. Full article
Open AccessConference Report
The Stability of Salmon Calcitonin Against Trypsin, Chymotrypsin and Neutrophil Elastase in Human Lung Epithelial Cells
Sci. Pharm. 2010, 78(3), 720; https://doi.org/10.3797/scipharm.cespt.8.POT05 - 12 Jul 2010
Viewed by 391
Abstract
At least three enzymes (i. e., trypsin, chymotrypsin and neutrophil elastase) are responsible for the degradation of salmon calcitonin (sCT) in the human body [1]. [...]
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Open AccessConference Report
Natural Surfactant of Alkyl Polyglucoside Type: A Physicochemical Characterization of New Mixed Emulsifier
Sci. Pharm. 2010, 78(3), 719; https://doi.org/10.3797/scipharm.cespt.8.POT04 - 12 Jul 2010
Viewed by 469
Abstract
In the light of the current trend for natural surfactants to be used as emulsifiers [1], a physicochemical characterization of a new mixed alkyl polyglucoside (APG) emulsifier (Arahidyl&Behenyl alcohol&Arahidyl glucoside) was performed. [...]
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Open AccessConference Report
A Coupled Kinetic-Dynamic Model Characterising Cell Cycle Response to an Anti-Cancer Agent
Sci. Pharm. 2010, 78(3), 718; https://doi.org/10.3797/scipharm.cespt.8.POT03 - 12 Jul 2010
Viewed by 452
Abstract
Topotecan (TPT) is a semi-synthetic derivative of the natural extract camptothecin, which has been found to act as an inhibitor of the DNA enzyme topoisomerase I in a specific and reversible fashion. [...]
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Open AccessConference Report
Development of Intermediate Layer with Improved Diffusional Barrier
Sci. Pharm. 2010, 78(3), 717; https://doi.org/10.3797/scipharm.cespt.8.POT02 - 12 Jul 2010
Cited by 1 | Viewed by 445
Abstract
Delayed release dosage form development usually requires an effective intermediate layer for separation of acid liable drug and acidic gastric polymer. [...]
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Open AccessConference Report
The Potential of Sucrose Esters to be used as Oral Absorption Enhancers
Sci. Pharm. 2010, 78(3), 716; https://doi.org/10.3797/scipharm.cespt.8.POT01 - 12 Jul 2010
Cited by 1 | Viewed by 508
Abstract
Overcoming biological barriers, including the gastrointestinal epithelial barriers, is a great challenge for pharmaceutical research. [...]
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Open AccessConference Report
Protein Characterization in Solution by Small-Angle X-Ray Scattering
Sci. Pharm. 2010, 78(3), 715; https://doi.org/10.3797/scipharm.cespt.8.PPAT26 - 12 Jul 2010
Viewed by 431
Abstract
For many biomedical applications of proteins the knowledge of the threedimensional structure of proteins is of great importance. [...]
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Open AccessConference Report
Application of 14N NQR to the Study of Sulfanilamide, Piroxicam, and Nifedipine Polymorphism
Sci. Pharm. 2010, 78(3), 714; https://doi.org/10.3797/scipharm.cespt.8.PPAT25 - 12 Jul 2010
Viewed by 463
Abstract
14N NQR is a new method in pharmacy that has a potential to establish itself as an additional and valuable analytical tool for characterizing solid state of a substance [1]. [...]
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Open AccessConference Report
Morphologically Directed Raman Spectroscopy as a Novel Tool to Monitor Changes in Particle Size and Shape in Solid Dosage Blends and Formulations
Sci. Pharm. 2010, 78(3), 713; https://doi.org/10.3797/scipharm.cespt.8.PPAT24 - 12 Jul 2010
Viewed by 432
Abstract
One of the key steps in the manufacturing of solid oral dosage formulations is the blending of several ingredients in powdered form which are then processed further to achieve the final dosage form. [...]
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Open AccessConference Report
Caffeine Nucleation Detection Using a Matrix of External Turbidity Probes: Bulk Video Imaging (BVI)
Sci. Pharm. 2010, 78(3), 712; https://doi.org/10.3797/scipharm.cespt.8.PPAT23 - 12 Jul 2010
Viewed by 444
Abstract
The purpose of this work is two fold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the nucleation detection in comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement [...] Read more.
The purpose of this work is two fold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the nucleation detection in comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement (FBRM) and ultra violet/visible (UV/Vis) spectroscopy. [...]
Full article
Open AccessConference Report
Mechanical Influences During Dissolution Testing in a Novel Peristaltic Movement Simulating Stirring Device
Sci. Pharm. 2010, 78(3), 711; https://doi.org/10.3797/scipharm.cespt.8.PPAT22 - 12 Jul 2010
Cited by 1 | Viewed by 501
Abstract
Mechanical stress caused by gastrointestinal motility might have a great impact on drug release from oral dosage forms. [...]
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Open AccessConference Report
Innovative Concepts for Personnel Locks in Clean Room Technology
Sci. Pharm. 2010, 78(3), 710; https://doi.org/10.3797/scipharm.cespt.8.PPAT21 - 12 Jul 2010
Viewed by 448
Abstract
Existing concepts for personnel locks in clean rooms are characterized by cost and time consuming procedures. [...]
Full article
Open AccessConference Report
Application of Dynamic Neural Networks and Fuzzy Algorithms in the Modeling of Drug Release
Sci. Pharm. 2010, 78(3), 709; https://doi.org/10.3797/scipharm.cespt.8.PPAT20 - 12 Jul 2010
Viewed by 424
Abstract
The aim of the presented study is to propose the utilization of dynamic neural networks and fuzzy algorithms as in silico tools for prediction of drug release rate from hydrophilic and lipid matrix tablets. Full article
Open AccessConference Report
Characterization of Biomedical Surfaces by Streaming Potential Measurements
Sci. Pharm. 2010, 78(3), 708; https://doi.org/10.3797/scipharm.cespt.8.PPAT19 - 12 Jul 2010
Viewed by 388
Abstract
The knowledge of surface charge and the isoelectric point is important for many biomedical applications. [...]
Full article
Open AccessConference Report
Enzyme-Catalyzed Synthesis of 2-Azido-2-deoxy-D-glucose under Catalysis by Recombinant Cellobiose Phosphorylase (CeP)
Sci. Pharm. 2010, 78(3), 707; https://doi.org/10.3797/scipharm.cespt.8.PPAT18 - 12 Jul 2010
Viewed by 387
Abstract
The use of enzyme-catalyzed reactions for the synthesis of sugar substrates represents a more desirable approach in terms of “green chemistry”. [...]
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Open AccessConference Report
Multidisciplinary Approach on Characterizing Composites of Vinpocetine and Crospovidone Obtained by Solid State Activation
Sci. Pharm. 2010, 78(3), 706; https://doi.org/10.3797/scipharm.cespt.8.PPAT17 - 12 Jul 2010
Viewed by 420
Abstract
The poorly-soluble Vinpocetine was successfully coground with micronized crospovidone in a planetary mill, which allowed an enhancement of bioavailability through a solid-state activation. [...]
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Open AccessConference Report
Evaluation of Sodium Naproxen Hydrated Forms by Isoconversional Analysis
Sci. Pharm. 2010, 78(3), 705; https://doi.org/10.3797/scipharm.cespt.8.PPAT16 - 12 Jul 2010
Viewed by 540
Abstract
Sodium naproxen (SN) exists in an anhydrous form and in four different hydrated forms: one monohydrate (MSN), two dehydrates (DSN and CSN) and one tetrahydrate (TSN). [...]
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Open AccessConference Report
A Simple High-Throughput Method for Determination of Pregabalin in Pharmaceutical Dosage Forms using a Microplate Fluorescence Reader
Sci. Pharm. 2010, 78(3), 704; https://doi.org/10.3797/scipharm.cespt.8.PPAT15 - 12 Jul 2010
Cited by 2 | Viewed by 424
Abstract
Pregabalin is a structural analogue of γ-aminobutyric acid approved for treatment of neuropathic pain, as adjunctive therapy for partial seizures, and in generalized anxiety disorder. [...]
Full article
Open AccessConference Report
Tailored Stationary Phases for Continuous Electro-Chromatographic Separation of APIs
Sci. Pharm. 2010, 78(3), 703; https://doi.org/10.3797/scipharm.cespt.8.PPAT14 - 12 Jul 2010
Viewed by 396
Abstract
Highly purified organic materials are essential in various fields, including the fine-chemical, pharmaceutical and food industry. [...]
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Open AccessConference Report
In Vitro-In Silico Tools to Identify Biorelevant Dissolution Specifications for the Selected Poorly-Soluble Model Drugs
Sci. Pharm. 2010, 78(3), 702; https://doi.org/10.3797/scipharm.cespt.8.PPAT13 - 12 Jul 2010
Viewed by 406
Abstract
Introduction: The most commonly used drug physicochemical property to access its in vivo performance is in vitro dissolution of a drug product. Full article
Open AccessConference Report
Application of Experimental Design for Screening Study of Dissolution Test Conditions: Levothyroxine Sodium Immediate-Release Tablets
Sci. Pharm. 2010, 78(3), 701; https://doi.org/10.3797/scipharm.cespt.8.PPAT12 - 12 Jul 2010
Viewed by 457
Abstract
The aim of the study was to present an example of experimental design application to set up the dissolution test conditions for the two immediaterelease products of levothyroxine sodium (L-Na) with proven bioequivalence: the generic product A and the reference product B [1, [...] Read more.
The aim of the study was to present an example of experimental design application to set up the dissolution test conditions for the two immediaterelease products of levothyroxine sodium (L-Na) with proven bioequivalence: the generic product A and the reference product B [1, 2]. [...]
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