2010 September - 203 articles
The present study was designed for the development of a stable sustained release liposomal drug delivery system for tamoxifen citrate (TC) using soya phosphatidylcholine (SPC), cholesterol (CH) and span 20 as main ingredients. Liposomes were prepared...
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There is very often a great gap between the performance of oral drug delivery systems in vitro and in vivo. [...]
Several inter-related issues relevant for the development of novel drug delivery systems are covered in the talk. [...]
Almost alone among the process industries, the pharmaceutical industry has tended to rely on batch operations. [...]
Most currently produced pharmaceutical formulations are based on a single molecular entity – the active pharmaceutical ingredient (API) – that is synthesised in a dedicated (bio)chemical plant and then has to be stable throughout the supply chain all...
Inflammatory bowel diseases, such as Morbus Crohn or Colitis Ulcerosa, are painful for the patient and moreover difficult to treat due to the increased mucus production and the occurrence of diarrhea. [...]
Nanoparticles represent useful drug delivery systems for the specific transport of drugs to target cells and tissues. [...]
Nanoparticles (NP) are increasingly used in a wide range of applications in science, technology and medicine. [...]
Understanding the intracellular localisation of biomedical nanoparticles (NPs), such as their co-localisation within cellular organells, e. g. endosomes, lysosomes, mitochondria or nuclei, or, alternatively free in the cytosol, can provide essential...
Continuous processing offers many advantages in pharmaceutical manufacturing. [...]
Different solid state characterization techniques have been widely used to gain a better understanding of the physical solid state characteristics of drug substances and drug formulations. [...]
Coating of tablets is an important way to design properties of the final dosage form. [...]
The majority of active agents used in medicinal therapy belong to category BCS II, which means that they have poor dissolution and good absorption properties, thus their absorption can be controlled and promoted first of all with various formulation...
Variability among individuals that affects clinical outcome is still one of the major challenges in drug development and in the practice of medicine. [...]
The dramatic changes in the demographics will increase the number of elderly people from today’s 10 % to 20% of the population in 2050, which is considered of one of the biggest challenge for our society. [...]
Probiotic microorganisms have been shown to provide specific health benefits when consumed as food supplements or as food components. [...]
It was the purpose of this study to develop an oral oligonucleotide delivery system based on thiolated polymer/ reduced glutathione (GSH) system providing protective effect towards nucleases, permeation enhancement and controlled drug release. [...]
Mupirocin-loaded microparticles (MP) were designed to control drug release at the skin surface assuring that drug remains localized at the application site and does not unnecessarily enter into the systemic circulation [1]. [...]
Monoglycerides, Phytantriol and a few other lipophilic molecules self-assemble in bulk in presence of water to form well defined liquid crystalline phases. [...]
Background: Lactose intolerance is the inability to metabolize lactose because of the absence of the enzyme lactase. It is estimated that 75–90% of birth lactase levels are lost by most people after weaning. [...]
Skin is main target for UV-oxidative stress and their antioxidant defenses can be quickly overcome. [...]
Cationic SLN formulations were developed and optimized in terms of cationic lipid/surfactant ratio and production parameters. [...]
Pharmaceutical secondary manufacturing has long stood in stark contrast to the drug discovery end of the business, as well as to other sectors, when it comes to innovation such as continuous manufacturing. [...]
Granular flows are of paramount importance in industry and nature. [...]
Porous particles are present in various technical applications as well as in the field of medical treatment. [...]
Numerical methods such as Finite Element Analysis (FEA) or Computational Fluid Dynamics (CFD) are considered to be well established technologies in industrial design and engineering. [...]
This contribution describes the dynamic optimization of a pharmaceuticals batch dryer. [...]
In the pharmaceutical industry spray coating is a frequently used method to apply a film layer on the surface of tablets or pellets. [...]
The impact of liquid drops on wetted and dry surfaces is a complex two-phase flow phenomenon with high technical relevance especially in surface coating. [...]
Magnetoliposomes (MLs) are phospholipid vesicles encapsulating magnetic nanoparticles utilised as contrast agents for targeted molecular Magnetic Resonance Imaging (MRI). [...]
Ultrasound active liposomes currently have gained a lot of interest as therapeutic agents for targeted drug delivery. [...]
Specially engineered drug particles can solve solubility and formulation problems, [...]
The availability and use of appropriate Process Analytical Technology (PAT) is fundamental to achieving the transformed style of pharmaceutical manufacture that is envisaged by the regulators. [...]
The aim of Process Analytical Technology (PAT) is to gain deeper insight in pharmaceutical manufacturing processes, [...]
Near-infrared spectroscopy (NIRS) is a rapid and nondestructive analytical method. [...]
Background: The use of nano-sized materials (NMs) offers exciting new options in technical and medical applications. Adverse effects on cells and organs, however, [...]
Praziquantel (PZQ) is a drug active against all species of Schistosoma and it is the drug of choice for the treatment of schistosomiasis [1]. [...]
Many current dermatological preparations, sunscreens and other cosmetics, contain nanosized particles (NPs), which were observed to be rapidly internalized by keratinocytes [1]. [...]
Introduction: The oral cavity acts as a complex barrier and displays the first main hindrance against uncontrolled uptake of a variety of substances. [...]
Studies on nasal epithelial models are important to develop vehicles for systemic nasal drug delivery, and also for targeting drugs to brain via the nasal route. [...]
Introduction: Nanotechnologies and Nanomedicine are promising fields of scientific research. [...]
Powder mixing is crucial for many processing stages within the pharmaceutical, catalysis, food, cement, and mineral industries, to name a few. [...]
Introduction: Xanthan (XAN) is a well known negatively charged biopolymer that adopts different conformations in media, which are still poorly understood. [...]
Dry powder coating is a relatively new technique to coat substrates without the use of any organic solvent or water. [...]
Coated pellets offer several advantages related to safety and effectiveness of the medicinal product such as reproducibility of gastric emptying and of absorption, and predictable plasma levels with lower probability of dose dumping due to modified r...
Hot Melt Extrusion, proven state-of-the-art technology in the field of plastics, is becoming increasingly important in the pharmaceutical industry. [...]
The control of particulate processes and their understanding can be improved by modern measuring techniques. [...]
To establish a micro fluidic system that covers the whole production process of drug-loaded solid lipid nanoparticles especially high pressure emulsification and dispersion processes must be taken into account. [...]
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