1,683 Results Found

The global dissemination of bacteria producing New Delhi metallo-β-lactamase (NDM-1) severely compromises the effectiveness of β-lactam antibiotics and restricts available therapeutic options. Owing to the structural and functional complexi...

Background: Pharmaceutical excipients are increasingly recognized as active determinants of formulation performance, manufacturability, stability, and safety. Artificial intelligence (AI) and machine learning (ML) are being explored to support excipi...

Anxiety and depression are prevalent neuropsychiatric disorders, and Lamiaceae species have shown neuroprotective and psychotropic properties. However, no systematic review with quantitative synthesis has specifically assessed phytochemically charact...

Leaves of plants in the Zingiberaceae family are traditionally consumed as vegetables and used as herbal ingredients. However, the phytochemical composition and bioactive potential of Zingiberaceae leaves remain less investigated than those of rhizom...

ICH Q1B sets a standardized photostability test for new drug substances and products, with a confirmatory exposure of at least 1.2 × 10⁶ lux hours of visible light and 200 W·h/m² of near-ultraviolet energy. It was finalized in 1996, when...

Antimicrobial peptides (AMPs) interact with bacterial membranes through mechanisms influenced by both peptide properties and membrane lipid composition. This study investigated the interactions of crotalicidin (Ctn) and its C-terminal fragment (Ctn[1...

Concurrent use of Withania somnifera (WS, ashwagandha) preparations and ethanol (EtOH) is increasingly common, yet the consequences for glutamatergic signaling remain uncharacterized. Because N-methyl-D-aspartate (NMDA) receptors are a principal targ...

Background/Objectives: Obesity is a multifactorial chronic disease involving adipose tissue dysfunction, low-grade inflammation, oxidative stress, mitochondrial dysfunction, and insulin resistance, contributing to type 2 diabetes mellitus, metabolic...

The Endothelial Protein C Receptor (EPCR) is a transmembrane glycoprotein expressed on vascular endothelial cells. In cerebral malaria, binding of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants containing CIDRα1 domains...

Cucurbitacin B (CucB) has anti-inflammatory potential, but poor aqueous solubility and permeability limit its oral development. This study developed and evaluated a Soluplus^®-stabilized CucB nanosuspension (CucB-NS). The formulation was prepared...

Ionizing radiation induces oxidative and genotoxic stress through reactive oxygen and nitrogen species, resulting in cellular lipid and DNA damage. This study evaluated the radiomodifying activity of an ethanolic pomegranate peel extract (Punica gran...

Intranasal dry powder dosage forms have attracted interest in the last decade due to their advantages over liquid nasal dosage forms. These advantages include increased residence time in the nasal cavity, greater chemical stability and improved bioav...

Type 2 diabetes mellitus (T2DM) has been associated with cognitive impairment and an increased risk of dementia in women. This study examined the effects of subchronic metformin treatment on recognition memory and brain pathology in female diabetic m...

Accumulating evidence indicates extensive crosstalk between prostaglandin- and histamine-mediated signaling pathways. Histamine has been shown to induce COX-2 (Cyclooxygenase-2) expression and stimulate prostaglandin synthesis, whereas prostaglandins...

Macrophomina phaseolina, a necrotrophic fungus with global distribution, has emerged as a source of bioactive natural products. This study evaluated the antiviral potential of metabolites from M. phaseolina against herpes simplex virus 1 (HSV-1). A c...

Citrus bioflavonoids, especially hesperidin, have garnered interest for their pharmacological attributes. The clinical applicability of hesperidin is constrained by its limited absorption. This study aimed to prepare and characterize liquisolid syste...

Natural compounds, including curcumin, resveratrol and other polyphenols, exhibit biologically significant antimicrobial, anticancer and antioxidant activities, making them promising candidates for drug development. These bioactive compounds have bee...

Metastasis is responsible for the majority of cancer-related deaths. During metastasis, cancer cells undergo a series of biological events that allow them to invade surrounding tissues, disseminate through the bloodstream or lymphatic system, and col...

Hydrothermal vent communities are a source of bioactive compounds; some of these could be a potential anticancer therapy. Riftia pachyptila is a marine invertebrate endemic to hydrothermal vents. The dichloromethane–methanol (1:1) extracts were...

Chronic and difficult-to-heal wounds require topical agents that combine reparative activity with favorable local disposition and an acceptable preliminary safety profile. This study evaluated three orotic acid–1,2,4-triazole hybrids (1–3...

Beta-amyloid peptide (Aβ), the key pathogenic factor of Alzheimer’s disease (AD), induces oxidative stress-mediated neuronal damage, eventually leading to death. Madecassic acid (MAD), a natural triterpenoid isolated from Centella asiatica...

Bisoprolol and Lisinopril are among the most frequently used substances in pediatric cardiovascular affections. The medication supply to this age population is limited given the lack of appropriate pharmaceutical forms; therefore, pharmaceutical comp...

Natural phenolic compounds are plant-derived compounds known for their potent antioxidant and anti-inflammatory properties. In addition, natural phenolic compounds are being investigated for their potential applications in pain management, and tissue...

Flavonoids are plant-derived polyphenols found in fruits, vegetables, tea and other dietary sources. Global dementia prevalence is projected to rise sharply, and current disease-modifying therapies remain limited in efficacy. This gap has contributed...

Lysosomal exocytosis induced by the sequestration of hydrophobic weak-base drugs has been proposed as a mechanism of drug resistance (DR), although direct evidence for its quantitative relevance is lacking. Here, we compared the kinetics of lysosomal...

4-Thiazolidinone derivatives, a group of compounds with a broad spectrum of activity and anticancer properties, are used in medicine as anti-inflammatory, antiviral, antibacterial, antidiabetic, and blood pressure-lowering drugs; some of them are now...

Three series of benzylidene cinnamoylhydrazides (21 compounds) were synthesized and evaluated for cytotoxic activity against malignant and non-malignant cell lines. Among the compounds tested, 2d and 3c were the most active against Jurkat and CEM leu...

Alzheimer’s disease (DA) remains a major therapeutic challenge, and selective butyrylcholinesterase (BChE) inhibition has emerged as a promising strategy for symptomatic treatment, particularly in advanced stages. Herein, a series of novel quin...

Ragweed (Ambrosia artemisiifolia) pollen allergy is a major and growing public health problem worldwide, with clinical manifestations ranging from rhinitis and conjunctivitis to asthmatic episodes and anaphylaxis. The major ragweed allergen, Amb a 1,...

Background: Plasmodium falciparum, the most virulent malaria parasite, continues to develop resistance to available drugs. Mitragyna inermis (Rubiaceae) is traditionally used in Africa for the treatment of malaria and has shown antiplasmodial activit...

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and anti-inflammatory activity; however, its low aqueous solubility limits its dissolution rate and, consequently, its oral bioavailability. This stu...

Vancomycin (VCN) is a glycopeptide antibiotic widely used to treat Gram-positive infections such as those caused by methicillin-resistant Staphylococcus aureus (MRSA). Its narrow therapeutic window, high interindividual pharmacokinetic variability, a...

Multidrug resistance (MDR) has become a major global health threat, leading to the emergence of difficult-to-treat bacterial “superbugs” among both Gram-positive and Gram-negative species. In hospital settings, biofilm (BF)-producing stap...

Compounds isolated from the macroalga Caulerpa sertularioides have been reported to exhibit cytotoxic activity. The objective of this study was to assess the antioxidant effects of compounds isolated from C. sertularioides as well as their antiprolif...

Monoclonal antibody-based therapies are widely used in chronic immune-mediated diseases, but their periodontal effects, dentoalveolar safety signals, and exposure characteristics remain incompletely characterized. This scoping review mapped periodont...

Cancer is still one of the major causes of death globally. While there are many cancer therapies, they often come with significant adverse effects and limitations. A lot of studies have shown that using natural products can improve the efficacy of co...

Introduction: Heavily exuding wounds can macerate perilesional skin and favour infection. Information on the properties and use time of dressings should be clear and available to healthcare providers. Methods: Our aim was to evaluate the updated seri...

Elymus repens (L.) Gould has a long history of use in traditional medicine across the British Isles, particularly among Gaelic and Anglo-Saxon communities, where it has been employed as a diuretic and anti-inflammatory agent. Despite its ethnopharmac...

The World Health Organization (WHO) estimates that by 2050, bacterial resistance will cause 10 million deaths, of which approximately one million are associated with multidrug-resistant (MDR) microorganisms. Staphylococcus aureus is one of the bacter...

This study aimed to investigate the physical properties of native tapioca starch (TS) ag-glomerated using its gelatinized dispersion as an agglomerating agent and to evaluate the performance of the resulting agglomerate tablets. The results demonstra...

The translation of underutilized botanical resources into advanced therapeutic dosage forms represents a critical frontier in pharmaceutical sciences. This study systematically characterizes the phytochemical and biological profiles of three Acanthus...

Epilobium parviflorum Schreb. is a medicinal plant used traditionally against inflammatory disorders whose cytotoxic potential is still incompletely revealed. The current study investigates the phytochemical composition and in vitro cytotoxic activit...

Quinoline is a bicyclic aromatic heterocycle composed of a fused benzene and pyridine ring, and it has held an important place in medicinal chemistry for nearly two centuries. F. Runge first isolated it from coal tar in 1834, and it was later found t...

Cytokines are produced by immune and other cells and work as cellular messengers to regulate an immune response and other biological processes. As the main components of the tumor microenvironment (TME), cytokines are involved in the major events of...

Risperidone (RIS) oral solution has a bitter taste and is sometimes mixed with beverages to improve palatability and medication adherence. Although the package insert advises against mixing with tea beverages, the effects of beverage type and tea lea...

Azelaic acid (AZA) and salicylic acid (SA) are widely used active ingredients in pharmaceutical and cosmetic formulations for the treatment of acne, rosacea, hyperpigmentation, and other dermatological conditions. Despite their frequent co-administra...

Mistletoes of the genus Tristerix, native to South America, represent a unique group of mostly hemiparasitic plants with potential medicinal applications. This review synthesizes existing knowledge on their biological and phytochemical properties, fo...

The matrix metalloproteinases MMP-2 and MMP-9 are involved in extracellular matrix remodeling, inflammatory response, and tissue remodeling, and overactivity of certain metalloproteinases may also contribute to chronic wound healing. The aim of this...

Although the acute phase of the SARS-CoV-2 pandemic has subsided, the continued emergence of viral variants underscores the need for structurally diverse antiviral inhibitors. In this study, molecular docking followed by molecular dynamics (300 ns) s...

Cridanimod (acridoneacetic acid), the active ingredient of the immunomodulatory drug Cycloferon^®, has a well-characterized antiviral profile, but an unexplored analgesic potential. Bornane monoterpenes, notably (+)-camphor and (−)-fenchone,...