Non-Invasive Oligonucleotide Delivery System Based on a Thiolated Polymer: Development and In Vitro Evaluation

R. MARTIEN; H. HOYER; G. PERERA; A. BERNKOP-SCHNÜRCH

doi:10.3797/scipharm.cespt.8.LDD02

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12 July 2010

Non-Invasive Oligonucleotide Delivery System Based on a Thiolated Polymer: Development and In Vitro Evaluation

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Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, 55281 Yogyakarta, Indonesia

Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens-University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria

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Sci. Pharm.2010, 78(3), 556;https://doi.org/10.3797/scipharm.cespt.8.LDD02

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Abstract

It was the purpose of this study to develop an oral oligonucleotide delivery system based on thiolated polymer/ reduced glutathione (GSH) system providing protective effect towards nucleases, permeation enhancement and controlled drug release. [...]

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