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Diseases, Volume 12, Issue 3

March 2024 - 23 articles

Cover Story: Previous studies demonstrated abnormal upregulation of the transcription factor GATA3 in malignant Hodgkin and Reed–Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Nevertheless, the detailed characterization of the immunophenotypes of cell types expressing GATA3 in cHL remains incomplete. This retrospective single-centre cohort study examined the expression patterns of GATA3 both independently and in conjunction with B, T, NK, or macrophage-associated markers in patients with cHL. A statistically significant correlation was found between GATA3-negative cHL and unfavourable prognostic markers, including advanced age and elevated serum β2-microglobulin levels. The heterogeneous expression patterns of GATA3 in HRS cells, particularly in the NS subtype of cHL, provide additional evidence for the biological heterogeneity of cHL. View this paper
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Articles (23)

  • Review
  • Open Access
20 Citations
8,706 Views
18 Pages

Targeting Solute Carrier Transporters (SLCs) as a Therapeutic Target in Different Cancers

  • Ravi Bharadwaj,
  • Swati Jaiswal,
  • Erandi E. Velarde de la Cruz and
  • Ritesh P. Thakare

21 March 2024

Solute carrier (SLC) transporters constitute a vast superfamily of transmembrane proteins tasked with regulating the transport of various substances such as metabolites, nutrients, ions, and drugs across cellular membranes. SLC transporters exhibit c...

  • Article
  • Open Access
6 Citations
8,218 Views
10 Pages

Papillary Thyroid Cancer Trends in the Wake of the COVID-19 Pandemic: Is There a Shift toward a More Aggressive Entity?

  • Iyad Hassan,
  • Lina Hassan,
  • Farooq Bacha,
  • Mohammad Al Salameh,
  • Omran Gatee and
  • Wiam Hassan

20 March 2024

Background: Globally, the incidence of papillary thyroid cancer (PTC) has been increasing over the last few decades and it has become the second most common cancer in women in the UAE. There is some evidence to suggest that COVID-19 infection might b...

  • Article
  • Open Access
10 Citations
2,929 Views
13 Pages

Exploratory Evaluation of Pre-Treatment Inflammation Profiles in Patients with Colorectal Cancer

  • Catalin Vladut Ionut Feier,
  • Calin Muntean,
  • Sorana D. Bolboacă and
  • Sorin Olariu

20 March 2024

In light of the elevated incidence and consequential prognostic implications associated with colorectal cancer, a comprehensive investigation into the impact exerted by inflammatory status on patient management becomes imperative. A retrospective stu...

  • Article
  • Open Access
1 Citations
4,701 Views
17 Pages

Clinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines

  • Mei-Yun Cheng,
  • Hsuan-Chen Ho,
  • Jung-Lung Hsu,
  • Yi Wang,
  • Linyi Chen,
  • Siew-Na Lim,
  • Ming-Feng Liao and
  • Long-Sun Ro

20 March 2024

Various vaccines have been developed in response to the SARS-CoV-2 pandemic, and the safety of vaccines has become an important issue. COVID-19 vaccine-related central nervous system inflammatory demyelinating diseases (CNS IDDs) have been reported r...

  • Review
  • Open Access
7 Citations
7,228 Views
24 Pages

Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome

  • Victor Javier Cruz-Holguín,
  • Luis Didier González-García,
  • Manuel Adrián Velázquez-Cervantes,
  • Haruki Arévalo-Romero,
  • Luis Adrián De Jesús-González,
  • Addy Cecilia Helguera-Repetto,
  • Guadalupe León-Reyes,
  • Ma. Isabel Salazar,
  • Leticia Cedillo-Barrón and
  • Moisés León-Juárez

20 March 2024

In mammals, the placenta is a connection between a mother and a new developing organism. This tissue has a protective function against some microorganisms, transports nutrients, and exchanges gases and excretory substances between the mother and the...

  • Article
  • Open Access
2 Citations
2,412 Views
12 Pages

19 March 2024

(1) Background: Several researchers have highlighted a higher incidence of overweight and obesity among nurses, and others have analyzed the quality of nurses’ eating habits and their related physical activity levels. The present study assessed...

  • Systematic Review
  • Open Access
4 Citations
3,571 Views
14 Pages

The Assessment of SF-36 Survey for Quality-of-Life Measurement after Radical Cystectomy for Muscle-Invasive Bladder Cancer: A Systematic Review

  • Vlad Barbos,
  • Bogdan Feciche,
  • Silviu Latcu,
  • Alexei Croitor,
  • Vlad Dema,
  • Razvan Bardan,
  • Flaviu Ionut Faur,
  • Tudor Mateescu,
  • Dorin Novacescu and
  • Gherle Bogdan
  • + 1 author

16 March 2024

This study presents a systematic review of the literature on individuals’ health-related quality of life (HRQoL) following radical cystectomy for muscle-invasive bladder cancer (MIBC), utilizing the Short Form-36 Health Survey (SF-36) as a prim...

  • Article
  • Open Access
1 Citations
2,642 Views
15 Pages

Serum Pro-Inflammatory Cytokines and Leptin as Potential Biomarkers for Treatment Response and Toxicity in Locally Advanced Squamous Cell Carcinoma of the Head and Neck

  • Amani A. Alrehaili,
  • Amal F. Gharib,
  • Maha M. Bakhuraysah,
  • Afaf Alharthi,
  • Ohud Alsalmi,
  • Fouzeyyah Ali Alsaeedi,
  • Reem Ali Alhakami,
  • Kamilah Ali Alasmari,
  • Nuha Mohammed and
  • Wael H. Elsawy

11 March 2024

Squamous cell carcinoma of the head and neck (HNSCC) is a globally prevalent form of cancer with significant morbidity and mortality rates. The present study examines the relationship of serum pro-inflammatory cytokines and leptin levels with the eff...

  • Article
  • Open Access
2 Citations
3,060 Views
11 Pages

Association between Dietary Practice and Gait Speed in Community-Dwelling Older Adults with Overweight and Obesity: A Cross-Sectional Study

  • Leila Itani,
  • Massimo Pellegrini,
  • Dana Saadeddine,
  • Hanen Samouda,
  • Dima Kreidieh,
  • Hana Tannir and
  • Marwan El Ghoch

Slow gait speed is associated with poorer clinical outcomes and higher rates of functional limitation and mortality in older adults, especially when combined with overweight or obesity. Aging is also associated with nutritional deficits. The aim of o...

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Diseases - ISSN 2079-9721