Models of CNS Regeneration: Mind the Gap!
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 20588
Special Issue Editor
Special Issue Information
Dear Colleagues,
The regeneration of the central nervous system (CNS) remains an elusive target for basic researchers and clinicians in regenerative medicine. Progress in rodent models using stem cells to decrease the catastrophic effects of CNS damage and increase axonal growth has failed to translate to successful clinical treatment of humans. Clearly, there is a knowledge gap. This Special Issue aims to help bridge this gap by addressing how alternative approaches have been used to better understand mechanisms of CNS regeneration. Contributions from researchers across the field will present the latest research findings and discuss how this research helps provide a bigger picture of CNS regeneration across species and across evolutionary pressures, including in vivo, ex vivo, and in vitro models, encompassing adult stem cells, pluripotent stem cells, plasticity, systemic issues, and the wound microenvironment. In this way, the Special Issue will provide both an overview of our current knowledge from these alternative models and bring together expert opinion on what still needs to be discovered and translated to help improve the likelihood of successfully regenerating the human CNS.
Prof. Eustace Johnson
Guest Editor
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Keywords
- stem cell biology
- central nervous system
- axonal regeneration
- model organism
- in vivo
- in vitro
- clinical translation
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