Special Issue "Neutrophil Extracellular Traps"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (15 October 2019).
Interests: sialic acids; polysialic acid; glycoimmunology; siglecs; extracellular traps; innate immune system
As a part of the innate immune system, neutrophils play a key role during inflammation. An effective mechanism of these immune cells to counteract the invasion of pathogens is the reactive oxygen species (ROS)-dependent release of neutrophil extracellular traps (NETs). NET-fibers consist mainly of chromatin and granule proteins, which are released to trap and kill invaders. However, besides the positive outcomes of NETs, innumerable studies demonstrated that exaggerated NET-formation triggers several pathomechanisms, which can lead to life-threatening consequences like sepsis and thrombosis. Thus, not only the activation mechanisms, but also the modulation and inhibition of the release of NET are key points for the development of treatment strategies against such pathological situations.
This Special Issue is focused on the physiological and the pathophysiological roles of NETs in addition to the possibilities to modulate the activation of NET formation and the release of these NET fibers. This includes a comparison of NET mechanisms in different animal species forming a bridge between evolutionary biology and the biomedical sciences.
Dr. Sebastian P. Galuska
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- extracellular traps
- innate immune system