Biology, Volume 11, Issue 9
2022 September - 122 articles
Cover Story: Methylphenidate (MPH) is frequently used to treat attention-deficit/hyperactivity disorder (ADHD). However, not every patient clinically benefits from MPH to the same extent. In their study, Ulrich et al. applied machine learning techniques to clinical symptom scales to discern “Responders” from “Non-Responders” after 6 weeks of medication. Prior to treatment, a specific part of the brain’s salience network was hypo-connected with the putamen in the entire adult ADHD sample (N = 53), relative to 50 healthy controls. After treatment, connectivity changed almost to “normality” in Responders, but not in Non-Responders. Their findings are reminiscent of earlier positron emission tomography studies that suggest the modulation of dopaminergic brain regions for the successful treatment of ADHD with MPH. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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