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The Ascidian-Derived Metabolites with Antimicrobial Properties

Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(8), 510;
Received: 30 June 2020 / Revised: 7 August 2020 / Accepted: 11 August 2020 / Published: 13 August 2020
Among the sub-phylum of Tunicate, ascidians represent the most abundant class of marine invertebrates, with 3000 species by heterogeneous habitat, that is, from shallow water to deep sea, already reported. The chemistry of these sessile filter-feeding organisms is an attractive reservoir of varied and peculiar bioactive compounds. Most secondary metabolites isolated from ascidians stand out for their potential as putative therapeutic agents in the treatment of several illnesses like microbial infections. In this review, we present and discuss the antibacterial activity shown by the main groups of ascidian-derived products, such as sulfur-containing compounds, meroterpenes, alkaloids, peptides, furanones, and their derivatives. Moreover, the direct evidence of a symbiotic association between marine ascidians and microorganisms shed light on the real producers of many extremely potent marine natural compounds. Hence, we also report the antibacterial potential, joined to antifungal and antiviral activity, of metabolites isolated from ascidian-associate microorganisms by culture-dependent methods. View Full-Text
Keywords: ascidian; antibacterial; antimicrobial; antiviral; marine natural products; ascidian-associated microorganisms ascidian; antibacterial; antimicrobial; antiviral; marine natural products; ascidian-associated microorganisms
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MDPI and ACS Style

Casertano, M.; Menna, M.; Imperatore, C. The Ascidian-Derived Metabolites with Antimicrobial Properties. Antibiotics 2020, 9, 510.

AMA Style

Casertano M, Menna M, Imperatore C. The Ascidian-Derived Metabolites with Antimicrobial Properties. Antibiotics. 2020; 9(8):510.

Chicago/Turabian Style

Casertano, Marcello, Marialuisa Menna, and Concetta Imperatore. 2020. "The Ascidian-Derived Metabolites with Antimicrobial Properties" Antibiotics 9, no. 8: 510.

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