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Antibiotics, Volume 8, Issue 3 (September 2019)
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Cover Story (view full-size image) The discovery of new antibiotics has drastically decreased in the last 30 years. Finding new [...] Read more. The discovery of new antibiotics has drastically decreased in the last 30 years. Finding new classes of antimicrobials is a top priority in the fight against multidrug-resistant pathogens. Herein, we discuss a unique class of antimicrobials, the lasso peptides. We review lasso peptide biosynthesis, their antibiotic activity, and unique mechanisms of action. As interest in antimicrobial lasso peptides continues to grow, and further discovery and bio-engineering will facilitate their therapeutic and industrial commercialization. View this paper