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Antibiotics, Volume 8, Issue 3

September 2019 - 71 articles

Cover Story: The discovery of new antibiotics has drastically decreased in the last 30 years. Finding new classes of antimicrobials is a top priority in the fight against multidrug-resistant pathogens. Herein, we discuss a unique class of antimicrobials, the lasso peptides. We review lasso peptide biosynthesis, their antibiotic activity, and unique mechanisms of action. As interest in antimicrobial lasso peptides continues to grow, and further discovery and bio-engineering will facilitate their therapeutic and industrial commercialization. View this paper
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Articles (71)

  • Article
  • Open Access
20 Citations
10,389 Views
21 Pages

Antibiotic Use: A Cross-Sectional Study Evaluating the Understanding, Usage and Perspectives of Medical Students and Pathfinders of a Public Defence University in Malaysia

  • Mainul Haque,
  • Nor Azlina A. Rahman,
  • Judy McKimm,
  • Massimo Sartelli,
  • Golam Mohammad Kibria,
  • Md Zakirul Islam,
  • Siti Nur Najihah Binti Lutfi,
  • Nur Syamirah Aishah Binti Othman and
  • Shahidah Leong Binti Abdullah

19 September 2019

Background: Antimicrobial prescribing behaviors are often influenced by the local culture and prescribing appropriateness of medical doctors and other health care professionals. Globally, antimicrobial utilization practices have a profound impact on...

  • Article
  • Open Access
12 Citations
5,264 Views
12 Pages

Characterization of LysBC17, a Lytic Endopeptidase from Bacillus cereus

  • Steven M. Swift,
  • Irina V. Etobayeva,
  • Kevin P. Reid,
  • Jerel J. Waters,
  • Brian B. Oakley,
  • David M. Donovan and
  • Daniel C. Nelson

19 September 2019

Bacillus cereus, a Gram-positive bacterium, is an agent of food poisoning. B. cereus is closely related to Bacillus anthracis, a deadly pathogen for humans, and Bacillus thuringenesis, an insect pathogen. Due to the growing prevalence of antibiotic r...

  • Article
  • Open Access
33 Citations
5,976 Views
15 Pages

The Contribution of Efflux Pumps in Mycobacterium abscessus Complex Resistance to Clarithromycin

  • Júlia S. Vianna,
  • Diana Machado,
  • Ivy B. Ramis,
  • Fábia P. Silva,
  • Dienefer V. Bierhals,
  • Michael Andrés Abril,
  • Andrea von Groll,
  • Daniela F. Ramos,
  • Maria Cristina S. Lourenço and
  • Miguel Viveiros
  • + 1 author

18 September 2019

The basis of drug resistance in Mycobacterium abscessus is still poorly understood. Nevertheless, as seen in other microorganisms, the efflux of antimicrobials may also play a role in M. abscessus drug resistance. Here, we investigated the role of ef...

  • Article
  • Open Access
114 Citations
15,239 Views
18 Pages

17 September 2019

Seaweeds are gaining a considerable amount of attention for their antioxidant and antibacterial properties. Caulerpa racemosa and Caulerpa lentillifera, also known as ‘sea grapes’, are green seaweeds commonly found in different parts of t...

  • Article
  • Open Access
14 Citations
5,326 Views
8 Pages

Characterization of a Carbapenem-Resistant Kluyvera Cryocrescens Isolate Carrying Blandm-1 from Hospital Sewage

  • Ying Li,
  • Li Luo,
  • Zhijiao Xiao,
  • Guangxi Wang,
  • Chengwen Li,
  • Zhikun Zhang,
  • Yingshun Zhou and
  • Luhua Zhang

16 September 2019

Carbapenem-resistant Enterobacteriaceae have been a global public health issue in recent years. Here, a carbapenem-resistant Kluyvera cryocrescens strain SCW13 was isolated from hospital sewage, and was then subjected to whole-genome sequencing (WGS)...

  • Case Report
  • Open Access
3 Citations
6,459 Views
4 Pages

Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib

  • Ramy M. Hanna,
  • Maham Khalid,
  • Lama Abd El-Nour and
  • Umut Selamet

16 September 2019

Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and acti...

  • Article
  • Open Access
10 Citations
5,452 Views
16 Pages

16 September 2019

We assessed the prevalence of antibiotic resistant and antibiotic resistance genes for 49 Tetragenococcus halophilus (T. halophilus) strains isolated from Xuawei ham in China. The antibiotic resistance phenotype was detected by the Bauer–Kirby...

  • Article
  • Open Access
27 Citations
6,683 Views
9 Pages

12 September 2019

Data from the Google search engine enables the assessment of Google users’ interest in a specific topic. We analyzed the world trends in searches associated with the topics “antibiotics” and “probiotics” from January 2004 to June 2019, using Google T...

  • Article
  • Open Access
20 Citations
7,379 Views
12 Pages

Carbapenemase Genes and Multidrug Resistance of Acinetobacter Baumannii: A Cross Sectional Study of Patients with Pneumonia in Southern Vietnam

  • Cuong Hoang Quoc,
  • Thao Nguyen Thi Phuong,
  • Hai Nguyen Duc,
  • Trung Tran Le,
  • Hang Tran Thi Thu,
  • Si Nguyen Tuan and
  • Lan Phan Trong

12 September 2019

Background: Acinetobacter baumannii (Ab) is an opportunistic bacterial pathogen found in hospital-acquired infections including nosocomial pneumonia, especially multidrug-resistant Ab. This study aims to survey the drug resistance profiles of Ab isol...

  • Article
  • Open Access
13 Citations
6,600 Views
14 Pages

Structural Analysis of The OXA-48 Carbapenemase Bound to A “Poor” Carbapenem Substrate, Doripenem

  • Krisztina M. Papp-Wallace,
  • Vijay Kumar,
  • Elise T. Zeiser,
  • Scott A. Becka and
  • Focco van den Akker

11 September 2019

Carbapenem-resistant Enterobacteriaceae are a significant threat to public health, and a major resistance determinant that promotes this phenotype is the production of the OXA-48 carbapenemase. The activity of OXA-48 towards carbapenems is a puzzling...

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Antibiotics - ISSN 2079-6382