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Carbapenemase Genes and Multidrug Resistance of Acinetobacter Baumannii: A Cross Sectional Study of Patients with Pneumonia in Southern Vietnam

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The Pasteur Institute, Ho Chi Minh City 700000, Vietnam
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Department of health and applied science, Dong Nai Technology University, Dong Nai Province 710000, Vietnam
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Department of planning division, The Pasteur Institute, Ho Chi Minh City 700000, Vietnam
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College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
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Training center, The Pasteur Institute, Ho Chi Minh City 700000, Vietnam
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Department of microbiology, Thong Nhat Dong Nai General Hospital, Bien Hoa City, Dong Nai Province 710000, Vietnam
*
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(3), 148; https://doi.org/10.3390/antibiotics8030148
Received: 3 August 2019 / Revised: 28 August 2019 / Accepted: 9 September 2019 / Published: 12 September 2019
Background: Acinetobacter baumannii (Ab) is an opportunistic bacterial pathogen found in hospital-acquired infections including nosocomial pneumonia, especially multidrug-resistant Ab. This study aims to survey the drug resistance profiles of Ab isolated from patients in Thong Nhat Dong Nai General Hospital and assess the relationship between genotypes and antibiotic resistance; Methods: Ninety-seven Ab strains isolated from 340 lower respiratory tract specimens among pneumonia patients were used to screen the most common local carbapenemase genes. Antimicrobial susceptibility testing results and demographic data were collected and minimum inhibitory concentrations (MIC) of colistin were also determined; Results: Over 80% and 90% of Ab strains were determined as carbapenem-resistant and multidrug-resistant (MDR), respectively. Most of the strains carried carbapenemase genes, including blaOXA-51, blaOXA-23-like, blaOXA-58-like, and blaNDM-1, with proportions of 97 (100%), 76 (78.4%), 10 (10.3%), 6 (6.2%), respectively. Amongst these genes, blaOXA-23-like was the only gene which significantly influenced the resistance (p < 0.0001); and Conclusions: The severity of Ab antibiotic resistance is urgent and specifically related to carbapenemase encoding genes. Therefore, screening of MDR Ab and carbapenemase for better treatment options is necessary. View Full-Text
Keywords: Acinetobacter baumannii (Ab); MDR Ab; blaOXA-51; blaOXA-23-like; blaOXA-58-like; blaNDM-1 Acinetobacter baumannii (Ab); MDR Ab; blaOXA-51; blaOXA-23-like; blaOXA-58-like; blaNDM-1
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Hoang Quoc, C.; Nguyen Thi Phuong, T.; Nguyen Duc, H.; Tran Le, T.; Tran Thi Thu, H.; Nguyen Tuan, S.; Phan Trong, L. Carbapenemase Genes and Multidrug Resistance of Acinetobacter Baumannii: A Cross Sectional Study of Patients with Pneumonia in Southern Vietnam. Antibiotics 2019, 8, 148.

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