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Antibiotics, Volume 12, Issue 2

February 2023 - 239 articles

Cover Story: Severe periodontitis is a worldwide health problem that can lead to tooth loss and increased risk for a number of serious systemic diseases from periodontal pathogens entering the circulatory system and colonizing extra-oral sites and organs. The efficacy of a combined antimicrobial chemotherapy composed of non-surgical root debridement augmented with locally applied antiseptic agents and short-term systemic antibiotics chosen on the basis of microbiological testing was evaluated over 5 years on 35 adults with severe periodontitis refractory to conventional surgical periodontal therapy. The anti-infective treatment regimen controlled progressive periodontitis disease activity and markedly improved the clinical and microbiological status of the patients. View this paper
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Articles (239)

  • Article
  • Open Access
2 Citations
2,916 Views
11 Pages

Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses

  • Sudhanshu Shekhar,
  • Navdeep Kaur Brar,
  • Anders P. Håkansson and
  • Fernanda Cristina Petersen

20 February 2023

Emerging evidence suggests differential effects of therapeutic antibiotics on infant T cell responses to pathogens. In this study, we explored the impact of the treatment of mouse infants with amoxicillin and the human milk-derived antimicrobial HAML...

  • Article
  • Open Access
5 Citations
2,529 Views
10 Pages

The Activity of Calcium Glycerophosphate and Fluoride against Cariogenic Biofilms of Streptococcus mutans and Candida albicans Formed In Vitro

  • Thamires Priscila Cavazana,
  • Thayse Yumi Hosida,
  • Caio Sampaio,
  • Leonardo Antônio de Morais,
  • Douglas Roberto Monteiro,
  • Juliano Pelim Pessan and
  • Alberto Carlos Botazzo Delbem

20 February 2023

This study evaluated the effects of calcium glycerophosphate (CaGP), with or without fluoride (F), on dual-species biofilms of Streptococcus mutans and Candida albicans. The biofilms were treated three times with 0.125, 0.25, and 0.5% CaGP solutions,...

  • Article
  • Open Access
6 Citations
3,617 Views
15 Pages

Plant Secondary Metabolites on Efflux-Mediated Antibiotic Resistant Stenotrophomonas Maltophilia: Potential of Herbal-Derived Efflux Pump Inhibitors

  • Thi Huyen Thu Nguyen,
  • Ngoc Anh Thơ Nguyen,
  • Hai Dang Nguyen,
  • Thi Thu Hien Nguyen,
  • Mai Huong Le,
  • Minh Quan Pham,
  • Huu Nghi Do,
  • Kim Chi Hoang,
  • Serge Michalet and
  • Marie-Geneviève Dijoux-Franca
  • + 1 author

20 February 2023

During the process of adapting to metal contamination, plants produce secondary metabolites that have the potential to modulate multidrug-resistant (MDR) phenotypes; this is achieved by inhibiting the activity of efflux pumps to reduce the minimum in...

  • Article
  • Open Access
19 Citations
4,070 Views
19 Pages

Antimicrobial Susceptibility Profile of Pathogenic and Commensal Bacteria Recovered from Cattle and Goat Farms

  • Winnie Mukuna,
  • Tobenna Aniume,
  • Bharat Pokharel,
  • Collins Khwatenge,
  • Ashesh Basnet and
  • Agnes Kilonzo-Nthenge

20 February 2023

The use of antibiotics in food animals results to antimicrobial resistant bacteria that complicates the ability to treat infections. The purpose of this study was to investigate the prevalence of pathogenic and commensal bacteria in soil, water, manu...

  • Article
  • Open Access
14 Citations
4,210 Views
12 Pages

Molecular Detection of Tetracycline-Resistant Genes in Multi-Drug-Resistant Escherichia coli Isolated from Broiler Meat in Bangladesh

  • Gazi Sofiul Alam,
  • Mohammad Mahmudul Hassan,
  • Md. Ahaduzzaman,
  • Chandan Nath,
  • Pronesh Dutta,
  • Hamida Khanom,
  • Shahneaz Ali Khan,
  • Md Ridoan Pasha,
  • Ariful Islam and
  • Ricardo Soares Magalhaes
  • + 1 author

20 February 2023

This study aimed to estimate the antimicrobial resistance (AMR) patterns and tetracycline-resistant gene profiles of Escherichia coli (E. coli) from broiler meat and livers sourced from live bird markets (LBMs) and supermarkets (SMs) in Chattogram, B...

  • Article
  • Open Access
25 Citations
4,682 Views
13 Pages

The RND Efflux Pump Gene Expression in the Biofilm Formation of Acinetobacter baumannii

  • Ola A. Abd El-Rahman,
  • Fatma Rasslan,
  • Safaa S. Hassan,
  • Hossam M. Ashour and
  • Reham Wasfi

20 February 2023

Multidrug resistant (MDR) Acinetobacter baumannii is a critical opportunistic pathogen in healthcare-associated infections (HAI). This is attributed to several factors, including its ability to develop biofilms that can enhance antimicrobial resistan...

  • Review
  • Open Access
36 Citations
8,560 Views
20 Pages

Bacteriophage Therapy as an Application for Bacterial Infection in China

  • Shuang Liang,
  • Yanling Qi,
  • Huabo Yu,
  • Wuwen Sun,
  • Sayed Haidar Abbas Raza,
  • Nada Alkhorayef,
  • Samia S. Alkhalil,
  • Essam Eldin Abdelhady Salama and
  • Lei Zhang

20 February 2023

Antibiotic resistance has emerged as a significant issue to be resolved around the world. Bacteriophage (phage), in contrast to antibiotics, can only kill the target bacteria with no adverse effect on the normal bacterial flora. In this review, we de...

  • Article
  • Open Access
5 Citations
3,037 Views
11 Pages

Quinolone Resistance Genes and Their Contribution to Resistance in Vibrio cholerae Serogroup O139

  • Yan-Yan Zhou,
  • Li-Yan Ma,
  • Li Yu,
  • Xin Lu,
  • Wei-Li Liang,
  • Biao Kan and
  • Jian-Rong Su

20 February 2023

Background. Quinolones are commonly used for reducing the duration of diarrhea, infection severity, and limiting further transmission of disease related to Vibrio cholerae, but V. cholerae susceptibility to quinolone decreases over time. In addition...

  • Article
  • Open Access
2 Citations
3,136 Views
14 Pages

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

  • Mengyao Li,
  • Mohammad A. K. Azad,
  • Philip E. Thompson,
  • Kade D. Roberts,
  • Tony Velkov,
  • Yan Zhu and
  • Jian Li

20 February 2023

Polymyxins are last-line antibiotics for the treatment of Gram-negative ‘superbugs’. However, nephrotoxicity can occur in up to 60% of patients administered intravenous polymyxins. The mechanisms underpinning nephrotoxicity remain unclear...

  • Article
  • Open Access
15 Citations
3,658 Views
18 Pages

20 February 2023

In ready-to-eat products, such as cooked ham, fresh cheese, and fuet in which Listeria monocytogenes is a concern, the use of biopreservation techniques represents an additional hurdle to inhibit pathogen growth during storage. The objective of this...

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Antibiotics - ISSN 2079-6382