Design, Synthesis, and Application of Antimicrobial Peptides

Dear Colleagues,

The search for efficient antimicrobial therapies to treat infections caused by resistant bacteria is in higher demand than ever before. The prolonged use of existing antibiotics has contributed to the development and spread of drug-resistant microorganisms that add a significant and increasing burden to healthcare and society. Antimicrobial peptides (AMPs) found in the innate immune system of different organisms present a promising class of bioactive compounds that offers a potential solution to the antibiotic resistance problem due to their mode of action on microbial membranes. Bacterial failure to develop resistance against most antimicrobial peptides has made them an efficient tool which can impact the new era of antimicrobials. However, natural AMPs that are present in living organisms are not stable and can display elevated toxicity and hemolytic profiles. Therefore, it is necessary to implement rational design strategies to synthetic AMPs to overcome these disadvantages and further modify the chemical and physical properties of existing peptides. Hence, this Special Issue seeks manuscript submissions that further our understanding of the correlation between the design of peptides and their therapeutic profiles.

Dr. Natalia Molchanova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.