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Antibiotics, Volume 12, Issue 1

January 2023 - 184 articles

Cover Story: The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that of MRSA and various wild-type Gram-negative pathogens. The new compounds retain activity in the presence of the aminoglycoside phosphoryltransferase aminoglycoside modifying enzymes that act on the primary hydroxy group of typical 4,5-(2-deoxystreptamine)-type aminoglycoside and related apramycin derivatives. Unexpectedly, the two anomers have comparable activity for the inhibition of both bacterial ribosomes and the various bacterial strains tested. View this paper
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Articles (184)

  • Review
  • Open Access
29 Citations
7,101 Views
17 Pages

The introduction of antibiotics has revolutionized the treatment and prevention of microbial infections. However, the global spread of pathogens resistant to available antibiotics is a major concern. Recently, the WHO has updated the priority list of...

  • Article
  • Open Access
5 Citations
5,548 Views
9 Pages

Fluoroquinolones Are Useful as Directed Treatment for Complicated UTI in a Setting with a High Prevalence of Quinolone-Resistant Microorganisms

  • Arturo Artero,
  • Ian López-Cruz,
  • Laura Piles,
  • Juan Alberola,
  • José María Eiros,
  • Sofia Salavert and
  • Manuel Madrazo

Fluoroquinolones (FQs) have been widely used for treating urinary tract infections (UTIs); however, the increasing emergence of resistant strains has compromised their use. We aimed to know the usefulness of FQs for the treatment of community-acquire...

  • Article
  • Open Access
17 Citations
3,853 Views
14 Pages

Antibacterial Activity of Selected Essential Oils against Foodborne Pathogens and Their Application in Fresh Turkey Sausages

  • Branislav Šojić,
  • Predrag Ikonić,
  • Sunčica Kocić-Tanackov,
  • Tatjana Peulić,
  • Nemanja Teslić,
  • Miloš Županjac,
  • Ivana Lončarević,
  • Zoran Zeković,
  • Milica Popović and
  • Stefan Vidaković
  • + 1 author

Essential oils (EOs) isolated from different plant materials, namely Origanum majorana L., Satureja hortensis L., and Satureja montana L. (OMEO, SHEO, and SMEO, respectively), were used in fresh turkey sausage processing. The chemical composition and...

  • Article
  • Open Access
11 Citations
5,631 Views
25 Pages

Preparation of Bioactive De-Chlorophyll Rhein-Rich Senna alata Extract

  • Wah Wah Aung,
  • Kanokpon Panich,
  • Suchawalee Watthanophas,
  • Sutada Naridsirikul,
  • Juthaporn Ponphaiboon,
  • Wantanwa Krongrawa,
  • Pattranit Kulpicheswanich,
  • Sontaya Limmatvapirat and
  • Chutima Limmatvapirat

Senna alata leaves display various biological activities as a result of their rhein and phenolic composition. The objective of this study was to develop bioactive de-chlorophyll rhein-rich S. alata extracts. The rhein content was quantified using a v...

  • Review
  • Open Access
76 Citations
13,265 Views
33 Pages

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria

  • Nina Compagne,
  • Anais Vieira Da Cruz,
  • Reinke T. Müller,
  • Ruben C. Hartkoorn,
  • Marion Flipo and
  • Klaas M. Pos

Antimicrobial resistance (AMR) has become a major problem in public health leading to an estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and repeated use of antibiotics has led to bacterial strains that are partial...

  • Article
  • Open Access
11 Citations
4,038 Views
21 Pages

Chemical Profile, Anti-Microbial and Anti-Inflammaging Activities of Santolina rosmarinifolia L. Essential Oil from Portugal

  • Jorge M. Alves-Silva,
  • Maria José Gonçalves,
  • Ana Silva,
  • Carlos Cavaleiro,
  • Maria Teresa Cruz and
  • Lígia Salgueiro

Fungal infections and the accompanying inflammatory responses are associated with great morbidity and mortality due to the frequent relapses triggered by an increased resistance to antifungal agents. Furthermore, this inflammatory state can be exacer...

  • Article
  • Open Access
27 Citations
5,191 Views
16 Pages

Antibacterial Activity of Biodegradable Films Incorporated with Biologically-Synthesized Silver Nanoparticles and the Evaluation of Their Migration to Chicken Meat

  • Meiriele da S. das Neves,
  • Sara Scandorieiro,
  • Giovana N. Pereira,
  • Jhonatan M. Ribeiro,
  • Amedea B. Seabra,
  • Adriana P. Dias,
  • Fabio Yamashita,
  • Claudia B. dos R. Martinez,
  • Renata K. T. Kobayashi and
  • Gerson Nakazato

The food industry has been exploring the association of polymers with nanoparticles in packaging production, and active products are essential to increase the shelf life of food and avoid contamination. Our study developed starch-poly (adipate co-ter...

  • Article
  • Open Access
17 Citations
4,742 Views
24 Pages

Essential oils (EOs) and their vapour phase of Curcuma longa (Zingiberaceae), Cymbopogon citratus (Poaceae), Ocimum campechianum (Lamiaceae), and Zingiber officinale (Zingiberaceae) of cultivated plants grown in an Amazonian Ecuador area were chemica...

  • Article
  • Open Access
7 Citations
3,774 Views
11 Pages

Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis

  • Emanuele Russo,
  • Marta Velia Antonini,
  • Andrea Sica,
  • Cristian Dell’Amore,
  • Costanza Martino,
  • Emiliano Gamberini,
  • Luca Bissoni,
  • Alessandro Circelli,
  • Giuliano Bolondi and
  • Domenico Pietro Santonastaso
  • + 4 authors

Background: Trauma is a leading cause of death and disability. Patients with trauma undergoing invasive mechanical ventilation (IMV) are at risk for ventilator-associated events (VAEs) potentially associated with a longer duration of IMV and increase...

  • Article
  • Open Access
4 Citations
3,713 Views
11 Pages

Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis

  • Jinnam Kim,
  • Jung Ho Kim,
  • Hi Jae Lee,
  • Se Ju Lee,
  • Changhyup Kim,
  • Jung Ah Lee,
  • Ki Hyun Lee,
  • Won Kyung Pyo,
  • Jin Young Ahn and
  • Su Jin Jeong
  • + 4 authors

Appropriate postoperative antibiotic treatment in patients with infective endocarditis (IE) reduces the risks of recurrence and mortality. However, concerns about adverse drug reactions arise due to prolonged antibiotic usage. Therefore, we compared...

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Antibiotics - ISSN 2079-6382