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Antibiotics, Volume 12, Issue 1

January 2023 - 184 articles

Cover Story: The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that of MRSA and various wild-type Gram-negative pathogens. The new compounds retain activity in the presence of the aminoglycoside phosphoryltransferase aminoglycoside modifying enzymes that act on the primary hydroxy group of typical 4,5-(2-deoxystreptamine)-type aminoglycoside and related apramycin derivatives. Unexpectedly, the two anomers have comparable activity for the inhibition of both bacterial ribosomes and the various bacterial strains tested. View this paper
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Articles (184)

  • Article
  • Open Access
7 Citations
4,976 Views
14 Pages

Genotypically, 16S rRNA gene sequence analysis clearly differentiates between species. However, species delineation between Escherichia fergusonii and Escherichia coli is much more difficult and cannot be distinguished by 16S rRNA gene sequences alon...

  • Article
  • Open Access
6 Citations
2,513 Views
17 Pages

Behind the Curtain: In Silico and In Vitro Experiments Brought to Light New Insights into the Anticryptococcal Action of Synthetic Peptides

  • Tawanny K. B. Aguiar,
  • Nilton A. S. Neto,
  • Romério R. S. Silva,
  • Cleverson D. T. Freitas,
  • Felipe P. Mesquita,
  • Luciana M. R. Alencar,
  • Ralph Santos-Oliveira,
  • Gustavo H. Goldman and
  • Pedro F. N. Souza

Cryptococcus neoformans is the pathogen responsible for cryptococcal pneumonia and meningitis, mainly affecting patients with suppressed immune systems. We have previously revealed the mechanism of anticryptococcal action of synthetic antimicrobial p...

  • Article
  • Open Access
13 Citations
3,168 Views
12 Pages

Pseudomonas aeruginosa causes a wide range of acute and chronic infections. Aminoglycosides are a cornerstone of treatment, but isolates are often resistant. The purpose of this research was to better understand the genetic basis of aminoglycoside re...

  • Article
  • Open Access
20 Citations
5,103 Views
20 Pages

Semisynthetic Amides of Amphotericin B and Nystatin A1: A Comparative Study of In Vitro Activity/Toxicity Ratio in Relation to Selectivity to Ergosterol Membranes

  • Anna Tevyashova,
  • Svetlana Efimova,
  • Alexander Alexandrov,
  • Olga Omelchuk,
  • Eslam Ghazy,
  • Elena Bychkova,
  • Georgy Zatonsky,
  • Natalia Grammatikova,
  • Lyubov Dezhenkova and
  • Svetlana Solovieva
  • + 2 authors

Polyene antifungal amphotericin B (AmB) has been used for over 60 years, and remains a valuable clinical treatment for systemic mycoses, due to its broad antifungal activity and low rate of emerging resistance. There is no consensus on how exactly it...

  • Article
  • Open Access
5 Citations
2,776 Views
10 Pages

Antibiotics Used for COVID-19 In-Patients from an Infectious Disease Ward

  • Felicia Sturza,
  • Ștefan-Decebal Guță and
  • Gabriel-Adrian Popescu

Background: although the prevalence of bacterial co-infections for COVID-19 patients is very low, most patients receive empirical antimicrobial therapy. Furthermore, broad spectrum antibiotics are preferred to narrow spectrum antibiotics. Methods: in...

  • Article
  • Open Access
17 Citations
5,650 Views
14 Pages

Prevalence of Carbapenemase and Extended-Spectrum β-Lactamase Producing Enterobacteriaceae: A Cross-Sectional Study

  • Muhammad Muqaddas Mustafai,
  • Mavra Hafeez,
  • Safa Munawar,
  • Sakeenabi Basha,
  • Ali A. Rabaan,
  • Muhammad A. Halwani,
  • Abdulsalam Alawfi,
  • Amer Alshengeti,
  • Mustafa A. Najim and
  • Sara Alwarthan
  • + 4 authors

Enterobacteriaceae have been classified as severely drug resistant bacteria by the World Health Organization due to their extensive production and dissemination of carbapenemases (CPs) and extended-spectrum β-lactamases (ESBL). The current study...

  • Article
  • Open Access
16 Citations
4,260 Views
17 Pages

Determinants of Knowledge, Attitude, and Practices of Veterinary Drug Dispensers toward Antimicrobial Use and Resistance in Main Cities of Malawi: A Concern on Antibiotic Stewardship

  • Henson Kainga,
  • Marvin Collen Phonera,
  • Ibrahim Chikowe,
  • Elisha Chatanga,
  • Hlupikire Nyirongo,
  • Mike Luwe,
  • James Mponela,
  • Vincent Kachisi,
  • Nathani Kamanga and
  • Julius Chulu
  • + 14 authors

Antimicrobial resistance (AMR) is an emerging challenge to global public health. The use of antibiotics in the veterinary field is one of the contributing factors to AMR mostly due to poor knowledge, attitudes, and practices (KAP) of dispensers. Vete...

  • Article
  • Open Access
5 Citations
2,375 Views
8 Pages

Characteristics of tet(X4)−Producing Escherichia coli in Chicken and Pig Farms in Hunan Province, China

  • Jie Yang,
  • Gang Xiao,
  • Ning Xiao,
  • Zonghan Jiang,
  • Chao Jiang,
  • Yujuan Li,
  • Wenxin Chen,
  • Hongguang Lin,
  • Zhiliang Sun and
  • Jiyun Li

Background: The plasmid−mediated tigecycline resistance gene tet(X4) confers a high level of resistance to tigecycline. The experiment aims to investigate the prevalence and characterization of tet(X4) in Escherichia coli isolates from chicken...

  • Article
  • Open Access
10 Citations
3,132 Views
12 Pages

Antibiotic Resistance and Therapeutic Efficacy of Helicobacter pylori Infection in Pediatric Patients—A Tertiary Center Experience

  • Felicia Galoș,
  • Cătălin Boboc,
  • Mara-Ioana Ieșanu,
  • Mălina Anghel,
  • Andreea Ioan,
  • Elena Iana,
  • Maria Teodora Coșoreanu and
  • Anca Andreea Boboc

One of the most widespread bacterial infections worldwide, Helicobacter pylori is thought to affect almost half of the world’s population. Due to rising antibiotic resistance, treatment should be tailored according to antibiotic susceptibility...

  • Systematic Review
  • Open Access
16 Citations
10,013 Views
17 Pages

Microbiomes in Acne Vulgaris and Their Susceptibility to Antibiotics in Indonesia: A Systematic Review and Meta-Analysis

  • Lili Legiawati,
  • Paulus Anthony Halim,
  • Magna Fitriani,
  • Hardya Gustada Hikmahrachim and
  • Henry W. Lim

Hot and humid countries such as Indonesia have a higher prevalence of acne vulgaris (AV). The activity of skin microbes, not only Cutibacterium acnes, contribute to the formation of AV. Topical and oral antibiotics are routinely prescribed to treat A...

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Antibiotics - ISSN 2079-6382