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Antibiotics, Volume 12, Issue 1

January 2023 - 184 articles

Cover Story: The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that of MRSA and various wild-type Gram-negative pathogens. The new compounds retain activity in the presence of the aminoglycoside phosphoryltransferase aminoglycoside modifying enzymes that act on the primary hydroxy group of typical 4,5-(2-deoxystreptamine)-type aminoglycoside and related apramycin derivatives. Unexpectedly, the two anomers have comparable activity for the inhibition of both bacterial ribosomes and the various bacterial strains tested. View this paper
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Articles (184)

  • Article
  • Open Access
29 Citations
5,904 Views
12 Pages

Prevalence and Antibiogram Pattern of Klebsiella pneumoniae in a Tertiary Care Hospital in Makkah, Saudi Arabia: An 11-Year Experience

  • Naif A. Jalal,
  • Abdulrahman M. Al-Ghamdi,
  • Aiman M. Momenah,
  • Sami S. Ashgar,
  • Farkad Bantun,
  • Fayez Saeed Bahwerth,
  • Sumyya H. Hariri,
  • Ayman K. Johargy,
  • Abeer A. Barhameen and
  • Hamdi M. Al-Said
  • + 1 author

Infectious disease is one of the greatest causes of morbidity and mortality worldwide, and with the emergence of antimicrobial resistance, the situation is worsening. In order to prevent this crisis, antimicrobial resistance needs to be monitored car...

  • Article
  • Open Access
21 Citations
8,213 Views
16 Pages

Antibacterial Effect of 16 Essential Oils and Modulation of mex Efflux Pumps Gene Expression on Multidrug-Resistant Pseudomonas aeruginosa Clinical Isolates: Is Cinnamon a Good Fighter?

  • Răzvan Lucian Coșeriu,
  • Camelia Vintilă,
  • Mirela Pribac,
  • Anca Delia Mare,
  • Cristina Nicoleta Ciurea,
  • Radu Ovidiu Togănel,
  • Anca Cighir,
  • Anastasia Simion and
  • Adrian Man

The purpose of the study was to describe the antimicrobial activity of 16 common essential oils (EOs) on multidrug-resistant (MDR) Pseudomonas aeruginosa clinical isolates, including the determination of the effects on mex efflux pumps gene expressio...

  • Article
  • Open Access
10 Citations
3,181 Views
19 Pages

Clostridioides difficile (C. difficile) is the most common pathogen causing antibiotic-associated intestinal diseases in humans and some animal species, but it can also be present in various environments outside hospitals. Thus, the objective of this...

  • Review
  • Open Access
17 Citations
5,431 Views
14 Pages

The Role of Biomarkers in Influenza and COVID-19 Community-Acquired Pneumonia in Adults

  • Raquel Carbonell,
  • Gerard Moreno,
  • Ignacio Martín-Loeches,
  • María Bodí and
  • Alejandro Rodríguez

Pneumonia is a growing problem worldwide and remains an important cause of morbidity, hospitalizations, intensive care unit admission and mortality. Viruses are the causative agents in almost a fourth of cases of community-acquired pneumonia (CAP) in...

  • Review
  • Open Access
24 Citations
5,482 Views
29 Pages

Coumarin Triazoles as Potential Antimicrobial Agents

  • Siddappa A. Patil,
  • Aravind R. Nesaragi,
  • Raúl R. Rodríguez-Berrios,
  • Sydney M. Hampton,
  • Alejandro Bugarin and
  • Shivaputra A. Patil

Currently, in hospitals and community health centers, microbial infections are highly common diseases and are a leading cause of death worldwide. Antibiotics are generally used to fight microbial infections; however, because of the abuse of antibioti...

  • Article
  • Open Access
12 Citations
3,294 Views
12 Pages

Relationship between Penicillin-Binding Proteins Alterations and β-Lactams Non-Susceptibility of Diseased Pig-Isolated Streptococcus suis

  • Kamonwan Lunha,
  • Wiyada Chumpol,
  • Surasak Jiemsup,
  • Sukuma Samngamnim,
  • Pornchalit Assavacheep and
  • Suganya Yongkiettrakul

Streptococcus suis is a zoonotic pathogen causing disease in both animals and humans, and the emergence of increasingly resistant bacteria to antimicrobial agents has become a significant challenge globally. The objective of this study was to investi...

  • Review
  • Open Access
7 Citations
6,783 Views
23 Pages

Bacteria, filamentous fungi, and plants synthesize thousands of secondary metabolites with important biological and pharmacological activities. The biosynthesis of these metabolites is performed by networks of complex enzymes such as non-ribosomal pe...

  • Article
  • Open Access
11 Citations
5,292 Views
10 Pages

Molecular Characterization of Community- and Hospital- Acquired Methicillin-Resistant Staphylococcus aureus Isolates during COVID-19 Pandemic

  • Muhammad Sohail,
  • Moazza Muzzammil,
  • Moaz Ahmad,
  • Sabahat Rehman,
  • Mohammed Garout,
  • Taghreed M. Khojah,
  • Kholoud M. Al-Eisa,
  • Samar A. Breagesh,
  • Rola M. Al Hamdan and
  • Halimah I. Alibrahim
  • + 3 authors

Methicillin-resistant Staphylococcus aureus (MRSA) is a drug-resistant superbug that causes various types of community- and hospital-acquired infectious diseases. The current study was aimed to see the genetic characteristics and gene expression of M...

  • Review
  • Open Access
5 Citations
5,395 Views
18 Pages

Antibiotic stewardship in urologic reconstruction is critically important, as many patients will require indwelling catheters for days to weeks following surgery and thus are at risk of both developing catheter-associated urinary tract infections (CA...

  • Article
  • Open Access
10 Citations
2,861 Views
11 Pages

Biofilm Formation Ability of ESBL/pAmpC-Producing Escherichia coli Isolated from the Broiler Production Pyramid

  • Andrea Laconi,
  • Roberta Tolosi,
  • Ilias Apostolakos and
  • Alessandra Piccirillo

Escherichia coli able to produce extended spectrum β-lactamases (ESBLs) and plasmid-mediated AmpC β-lactamases (pAmpCs) represents a serious threat to public health, since these genes confer resistance to critically important antimicrobials...

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Antibiotics - ISSN 2079-6382