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Antibiotics, Volume 12, Issue 1

January 2023 - 184 articles

Cover Story: The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that of MRSA and various wild-type Gram-negative pathogens. The new compounds retain activity in the presence of the aminoglycoside phosphoryltransferase aminoglycoside modifying enzymes that act on the primary hydroxy group of typical 4,5-(2-deoxystreptamine)-type aminoglycoside and related apramycin derivatives. Unexpectedly, the two anomers have comparable activity for the inhibition of both bacterial ribosomes and the various bacterial strains tested. View this paper
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Articles (184)

  • Article
  • Open Access
10 Citations
3,281 Views
12 Pages

Antibiotic resistance is an issue in many areas of human activity. The mobilization of antibiotic resistance genes within the bacterial community makes it difficult to study and control the phenomenon. It is known that certain insertion sequences, wh...

  • Article
  • Open Access
18 Citations
3,801 Views
16 Pages

Chemical Composition, Antioxidants, Antibacterial, and Insecticidal Activities of Origanum elongatum (Bonnet) Emberger & Maire Aerial Part Essential Oil from Morocco

  • Imane Tagnaout,
  • Hannou Zerkani,
  • Noureddine Bencheikh,
  • Smail Amalich,
  • Mohamed Bouhrim,
  • Ramzi A. Mothana,
  • Mohammed R. Alhuzani,
  • Rachid Bouharroud,
  • Christophe Hano and
  • Touriya Zair

The aim of this research is to profile the chemical composition of the essential oil (EO) extracted from the aerial parts of Origanum elongatum (O. elongatum) and to evaluate its antioxidant, antibacterial and insecticidal activities on Ceratitis cap...

  • Article
  • Open Access
11 Citations
3,648 Views
13 Pages

Burden of Hospitalizations Related to Pneumococcal Infection in Spain (2016–2020)

  • Ruth Gil-Prieto,
  • Nizar Allouch,
  • Isabel Jimeno,
  • Valentín Hernández-Barrera,
  • Raquel Arguedas-Sanz and
  • Ángel Gil-de-Miguel

Pneumococcal infection strongly contributes to morbidity and mortality in Spain. A total of 253,899 hospitalizations related to pneumococcal infection occurred from 2016 to 2020. Fifty-eight percent were men, the mean age was 67 years old, and the av...

  • Article
  • Open Access
8 Citations
3,470 Views
13 Pages

Evaluation of Everolimus Activity against Mycobacterium tuberculosis Using In Vitro Models of Infection

  • Delia Mercedes Bianco,
  • Flavio De Maio,
  • Giulia Santarelli,
  • Ivana Palucci,
  • Alessandro Salustri,
  • Giada Bianchetti,
  • Giuseppe Maulucci,
  • Franco Citterio,
  • Maurizio Sanguinetti and
  • Enrica Tamburrini
  • + 2 authors

Even though Everolimus has been investigated in a phase II randomized trial as a host-directed therapy (HDT) to treat tuberculosis (TB), an oncological patient treated with Everolimus for a neuroendocrine pancreatic neoplasia developed active TB twic...

  • Article
  • Open Access
9 Citations
3,597 Views
15 Pages

Azithromycin Susceptibility Testing and Molecular Investigation of Neisseria gonorrhoeae Isolates Collected in Russia, 2020–2021

  • Ilya Kandinov,
  • Boris Shaskolskiy,
  • Dmitry Kravtsov,
  • Alexandra Vinokurova,
  • Sofya Gorshkova,
  • Alexey Kubanov,
  • Victoria Solomka,
  • Julia Shagabieva,
  • Dmitry Deryabin and
  • Ekaterina Dementieva
  • + 1 author

The aim of this work was to study the resistance to macrolides (azithromycin) in the modern Russian population of N. gonorrhoeae with the analysis of genetic resistance determinants. Azithromycin is not used to treat gonococcal infection in Russia. H...

  • Article
  • Open Access
42 Citations
7,869 Views
22 Pages

Multidrug-Resistant ESBL-Producing E. coli in Clinical Samples from the UK

  • Delveen R. Ibrahim,
  • Christine E. R. Dodd,
  • Dov J. Stekel,
  • Remilekun T. Meshioye,
  • Mathew Diggle,
  • Michelle Lister and
  • Jon L. Hobman

Globally, cephalosporin therapy failure is a serious problem for infection control. One causative agent of cephalosporin-resistant infections is multidrug-resistant (MDR) E. coli producing extended-spectrum β-lactamases (ESBLs) and/or plasmid-en...

  • Article
  • Open Access
23 Citations
4,210 Views
11 Pages

Hospital Antibiotic Use during COVID-19 Pandemic in Italy

  • Alessandro Perrella,
  • Filomena Fortinguerra,
  • Andrea Pierantozzi,
  • Nicolina Capoluongo,
  • Novella Carannante,
  • Andrea Lo Vecchio,
  • Francesca Futura Bernardi,
  • Francesco Trotta and
  • Agnese Cangini

Antimicrobial resistance (AMR) represents a major issue in healthcare being correlated to global inappropriate use of antibiotics. The aim of this study was to compare the data on hospital antibiotic consumption in 2020–2021 with those related...

  • Perspective
  • Open Access
6 Citations
10,030 Views
8 Pages

For decades, the potential role of probiotics in the prevention and treatment of recurrent urinary tract infections has been extensively studied. However, achieving an effective problem-solving strategy has thus far proven elusive. Perhaps adopting a...

  • Article
  • Open Access
11 Citations
4,276 Views
16 Pages

Antimicrobial Susceptibility and Molecular Features of Colonizing Isolates of Pseudomonas aeruginosa and the Report of a Novel Sequence Type (ST) 3910 from Thailand

  • Arnon Chukamnerd,
  • Rattanaruji Pomwised,
  • Sarunyou Chusri,
  • Kamonnut Singkhamanan,
  • Sanicha Chumtong,
  • Kongpop Jeenkeawpiam,
  • Chanida Sakunrang,
  • Kuwanhusna Saroeng,
  • Phanvasri Saengsuwan and
  • Monwadee Wonglapsuwan
  • + 1 author

Pseudomonas aeruginosa is an important pathogen as it can cause hospital-acquired infections. Additionally, it can also colonize in patients and in other various environments. Hence, this study aimed to investigate the antimicrobial susceptibility, a...

  • Article
  • Open Access
26 Citations
10,315 Views
13 Pages

First and Second-Line Anti-Tuberculosis Drug-Resistance Patterns in Pulmonary Tuberculosis Patients in Zambia

  • Ngula Monde,
  • Musso Munyeme,
  • Gershom Chongwe,
  • Jonas Johansson Wensman,
  • Mildred Zulu,
  • Seter Siziya,
  • Rabecca Tembo,
  • Kabengele K. Siame,
  • Obi Shambaba and
  • Sydney Malama

Background: Drug-resistant tuberculosis has continued to be a serious global health threat defined by complexity as well as higher morbidity and mortality wherever it occurs, Zambia included. However, the paucity of information on drug-susceptibility...

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Antibiotics - ISSN 2079-6382