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Journal of Functional Biomaterials, Volume 14, Issue 11

2023 November - 22 articles

Cover Story: AMPs are a promising bioactive class of molecules. The review highlights how the incorporation of AMPs into medical implants and biomaterials has exhibited remarkable potential in mitigating biofilm formation and preventing infections. Cutting-edge advancements in biomedical sciences take center stage, revealing the successful immobilization of AMPs to enhance their efficacy and stability within the implant environment. The narrative unfolds with a spotlight on the latest research, where AMP coatings have proven effective in treating surgical site infections (SSIs), dental applications, enhancing contact lenses, fortifying bone grafts, and combating urinary tract infections (UTIs). Each instance underscores the versatility and adaptability of AMPs in diverse clinical settings. View this paper
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Articles (22)

  • Article
  • Open Access
13 Citations
3,934 Views
20 Pages

Expanding the Scope of an Amphoteric Condensed Tannin, Tanfloc, for Antibacterial Coatings

  • Somayeh Baghersad,
  • Liszt Y. C. Madruga,
  • Alessandro F. Martins,
  • Ketul C. Popat and
  • Matt J. Kipper

18 November 2023

Bacterial infections are a common mode of failure for medical implants. This study aims to develop antibacterial polyelectrolyte multilayer (PEM) coatings that contain a plant-derived condensed tannin polymer (Tanfloc, TAN) with inherent antimicrobia...

  • Review
  • Open Access
12 Citations
4,352 Views
22 Pages

Rational Design of Multifunctional Hydrogels for Wound Repair

  • Juan Cao,
  • Bo Wu,
  • Ping Yuan,
  • Yeqi Liu and
  • Cheng Hu

18 November 2023

The intricate microenvironment at the wound site, coupled with the multi-phase nature of the healing process, pose significant challenges to the development of wound repair treatments. In recent years, applying the distinctive benefits of hydrogels t...

  • Article
  • Open Access
9 Citations
3,223 Views
16 Pages

Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties

  • Jiayu He,
  • Yuandong Liu,
  • Xiaofeng Zeng,
  • Yan Tong,
  • Run Liu,
  • Kan Wang,
  • Xiangdong Shangguan,
  • Guanzhou Qiu and
  • Coswald Stephen Sipaut

17 November 2023

Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from com...

  • Article
  • Open Access
1 Citations
2,387 Views
12 Pages

In Vitro Investigation into the Effect of Cryopreservation on the Mechanical Characteristics of Dental Hard Tissues

  • Noëmi M. C. De Roo,
  • Kaat Toulouse,
  • Laurent A. M. Thierens,
  • Silke Henry,
  • Stefanie De Buyser,
  • Liesbeth Temmerman,
  • Ronald M. H. Verbeeck and
  • Guy A. M. De Pauw

17 November 2023

Previous research has reported on hidden damage within the dentin introduced by cryopreservation, but the effect on the mechanical properties of the hard tissues at tooth level remains unclear. The main objective of this study is to investigate the e...

  • Article
  • Open Access
7 Citations
2,145 Views
13 Pages

Using Functionalized Micron-Sized Glass Fibres for the Synergistic Effect of Glass Ionomer on Luting Material

  • Hanan Alsunbul,
  • Aftab Ahmed Khan,
  • Yasser M. Alqahtani,
  • Saeed Awod bin Hassan,
  • Waleed Asiri,
  • Selma Saadaldin,
  • Rasha Alharthi and
  • Alhanoof Aldegheishem

16 November 2023

This laboratory experiment was conducted with the objective of augmenting the mechanical properties of glass ionomer cement (GIC) via altering the composition of GIC luting powder through the introduction of micron-sized silanized glass fibres (GFs)....

  • Article
  • Open Access
4 Citations
3,083 Views
29 Pages

New Functional Bionanocomposites by Combining Hybrid Host-Guest Systems with a Fully Biobased Poly(lactic acid)/Poly(butylene succinate-co-adipate) (PLA/PBSA) Binary Blend

  • Francesca Cicogna,
  • Elisa Passaglia,
  • Alice Telleschi,
  • Werner Oberhauser,
  • Maria-Beatrice Coltelli,
  • Luca Panariello,
  • Vito Gigante and
  • Serena Coiai

15 November 2023

In this study, we have developed innovative polymer nanocomposites by integrating magnesium-aluminum layered double hydroxide (LDH)-based nanocarriers modified with functional molecules into a fully biobased poly(lactic acid)/poly(butylene succinate-...

  • Article
  • Open Access
19 Citations
3,953 Views
15 Pages

15 November 2023

Ulcerative colitis (UC) is a refractory chronic inflammatory disease involving the colon and rectum, falling under the category of inflammatory bowel disease (IBD). The accumulation of reactive oxygen species (ROS) in local tissues has been identifie...

  • Article
  • Open Access
5 Citations
2,759 Views
15 Pages

Numerical Simulation of Dynamic Degradation and Fatigue Damage of Degradable Zinc Alloy Stents

  • Jing Qi,
  • Hanbing Zhang,
  • Shiliang Chen,
  • Tianming Du,
  • Yanping Zhang and
  • Aike Qiao

15 November 2023

Current research on the fatigue properties of degradable zinc alloy stents has not yet considered the issue of the fatigue life changing with material properties during the dynamic degradation process. Therefore, in this paper, we established a fatig...

  • Article
  • Open Access
7 Citations
2,947 Views
13 Pages

Hollow MIL-125 Nanoparticles Loading Doxorubicin Prodrug and 3-Methyladenine for Reversal of Tumor Multidrug Resistance

  • Qingfeng Guo,
  • Jie Li,
  • Jing Mao,
  • Weijun Chen,
  • Meiyang Yang,
  • Yang Yang,
  • Yuming Hua and
  • Lipeng Qiu

13 November 2023

Multidrug resistance (MDR) is a key factor in chemotherapy failure and tumor recurrence. The inhibition of drug efflux and autophagy play important roles in MDR therapy. Herein, a multifunctional delivery system (HA-MIL-125@DVMA) was prepared for syn...

  • Review
  • Open Access
29 Citations
8,877 Views
24 Pages

New Insights in Hydrogels for Periodontal Regeneration

  • Mafalda S. Santos,
  • Alexandra B. dos Santos and
  • Marta S. Carvalho

11 November 2023

Periodontitis is a destructive inflammatory disease characterized by microbial infection that damages the tissues supporting the tooth (alveolar bone, gingiva, periodontal ligament, and cementum), ultimately resulting in the loss of teeth. The ultima...

  • Review
  • Open Access
8 Citations
8,945 Views
24 Pages

10 November 2023

Coronary artery disease is the most prevalent cardiovascular disease, claiming millions of lives annually around the world. The current treatment includes surgically inserting a tubular construct, called a stent, inside arteries to restore blood flow...

  • Review
  • Open Access
6 Citations
3,993 Views
21 Pages

Recent Progress of In Vitro 3D Culture of Male Germ Stem Cells

  • Jiang Wu,
  • Kai Kang,
  • Siqi Liu,
  • Yaodan Ma,
  • Meng Yu and
  • Xin Zhao

8 November 2023

Male germline stem cells (mGSCs), also known as spermatogonial stem cells (SSCs), are the fundamental seed cells of male animal reproductive physiology. However, environmental influences, drugs, and harmful substances often pose challenges to SSCs, s...

  • Article
  • Open Access
7 Citations
4,605 Views
18 Pages

Assessment of the Penetration of an Endodontic Sealer into Dentinal Tubules with Three Different Compaction Techniques Using Confocal Laser Scanning Microscopy

  • Ignacio Barbero-Navarro,
  • Diego Velázquez-González,
  • María Esther Irigoyen-Camacho,
  • Marco Antonio Zepeda-Zepeda,
  • Paulo Mauricio,
  • David Ribas-Perez and
  • Antonio Castano-Seiquer

7 November 2023

Adequate root canal sealing is essential for the success of endodontic treatment. There are numerous techniques available; identifying simple and efficient techniques is important to provide good patient care. The purpose of the study was to compare...

  • Article
  • Open Access
10 Citations
3,925 Views
16 Pages

A pH-Responsive DNA Tetrahedron/Methotrexate Drug Delivery System Used for Rheumatoid Arthritis Treatment

  • Yi Jin,
  • Xingyu Ge,
  • Yinjin Xu,
  • Siyi Wang,
  • Qian Lu,
  • Aidong Deng,
  • Jingjing Li and
  • Zhifeng Gu

3 November 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to progressive and aggressive joint inflammation. The disease process is characterized by the activation of macrophages, which then release tumor necrosis factor-α (TNF-&alph...

  • Article
  • Open Access
17 Citations
5,076 Views
17 Pages

2 November 2023

Extracellular vesicles (EVs) are nano-sized vehicles secreted by all live cells to establish communication with adjacent cells. In recent years, mammalian EVs (MEVs) have been widely investigated for their therapeutic implications in human disease co...

  • Review
  • Open Access
25 Citations
5,601 Views
22 Pages

2 November 2023

Antimicrobial peptides (AMPs) have emerged as a promising class of bioactive molecules with the potential to combat infections associated with medical implants and biomaterials. This review article aims to provide a comprehensive analysis of the role...

  • Article
  • Open Access
7 Citations
3,337 Views
13 Pages

Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery

  • Carmen Grierosu,
  • Gabriela Calin,
  • Daniela Damir,
  • Constantin Marcu,
  • Radu Cernei,
  • Georgeta Zegan,
  • Daniela Anistoroaei,
  • Mihaela Moscu,
  • Elena Mihaela Carausu and
  • Lucian Eva
  • + 5 authors

1 November 2023

Nowadays, infection diseases are one of the most significant threats to humans all around the world. An encouraging strategy for solving this issue and fighting resistant microorganisms is to develop drug carriers for a prolonged release of the antib...

  • Article
  • Open Access
6 Citations
2,928 Views
11 Pages

Poly(Aspartic Acid) Promotes Odontoblast-like Cell Differentiation in Rat Molars with Exposed Pulp

  • Fernanda Furuse Ventura dos Santos,
  • Stefan Habelitz,
  • Fábio Dupart Nascimento,
  • Victor Elias Arana-Chavez and
  • Roberto Ruggiero Braga

1 November 2023

In recent years, alternative pulpal therapies targeting dentinogenesis signaling pathways using different peptides have been investigated. The aim of this study was to verify the effectiveness of poly(aspartic acid), pAsp, in dentin regeneration usin...

  • Article
  • Open Access
6 Citations
5,515 Views
17 Pages

30 October 2023

In the field of healthcare and dentistry, 316L stainless steel is widely used for its corrosion resistance. However, the presence of lactic acid in salivary solutions can affect its surface reactivity. This study employed electrochemical methods to i...

  • Article
  • Open Access
9 Citations
3,182 Views
16 Pages

PCLLA-nanoHA Bone Substitute Promotes M2 Macrophage Polarization and Improves Alveolar Bone Repair in Diabetic Environments

  • Dandan Wang,
  • Ling Wei,
  • Jialin Hao,
  • Weifeng Tang,
  • Yuan Zhou,
  • Chenguang Zhang and
  • Jinming Wang

30 October 2023

The utilization of bioresorbable synthetic bone substitutes with immunomodulatory properties has gained significant attention in dental clinical applications for the absorption of alveolar bone induced by orthodontic treatment. In this study, we deve...

  • Article
  • Open Access
6 Citations
3,806 Views
11 Pages

Concept of a Novel Glass Ionomer Restorative Material with Improved Mechanical Properties

  • Philipp Messer-Hannemann,
  • Henrik Böttcher,
  • Sven Henning,
  • Falk Schwendicke and
  • Susanne Effenberger

24 October 2023

The objective of this study was to transfer the concept of ductile particle reinforcement to restorative dentistry and to introduce an innovative glass ionomer material that is based on the dispersion of PEG-PU micelles. It was hypothesized that rein...

  • Article
  • Open Access
18 Citations
4,914 Views
18 Pages

Aligned Collagen Sponges with Tunable Pore Size for Skeletal Muscle Tissue Regeneration

  • Natalie G. Kozan,
  • Sean Caswell,
  • Milan Patel and
  • Jonathan M. Grasman

24 October 2023

Volumetric muscle loss (VML) is a traumatic injury where at least 20% of the mass of a skeletal muscle has been destroyed and functionality is lost. The standard treatment for VML, autologous tissue transfer, is limited as approximately 1 in 10 graft...

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J. Funct. Biomater. - ISSN 2079-4983