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Journal of Functional Biomaterials, Volume 10, Issue 2

2019 June - 10 articles

Cover Story: Biodentine™ is one of the most successful and widely reported calcium silicate-based endodontic cements. Despite this, very little is known about the formation and structure of the major calcium silicate hydrate (C-S-H) gel phase as it is difficult to obtain information on this poorly crystalline material by traditional X-ray diffraction analysis and infrared spectroscopy. Using Biodentine™ as an example, this study demonstrates how 29Si magic angle spinning nuclear magnetic resonance spectroscopy (29Si MAS NMR) can be used to determine the degree of hydration, relative abundance of the various Qn silicate species and the mean silicate chain length of the C-S-H gel phase of calcium silicate-based endodontic cements. View this paper.
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Articles (10)

  • Communication
  • Open Access
49 Citations
10,841 Views
14 Pages

Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT

  • Marcus Hill,
  • Richard N. Cunningham,
  • Rania M. Hathout,
  • Christopher Johnston,
  • John G. Hardy and
  • Marie E. Migaud

Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective anti...

  • Article
  • Open Access
30 Citations
9,916 Views
18 Pages

Biodentine is one of the most successful and widely studied among the second generation of calcium silicate-based endodontic cements. Despite its popularity, the setting reactions of this cement system are not currently well understood. In particular...

  • Feature Paper
  • Article
  • Open Access
14 Citations
8,756 Views
17 Pages

RGD-Modified Nanofibers Enhance Outcomes in Rats after Sciatic Nerve Injury

  • McKay Cavanaugh,
  • Elena Silantyeva,
  • Galina Pylypiv Koh,
  • Elham Malekzadeh,
  • William D. Lanzinger,
  • Rebecca Kuntz Willits and
  • Matthew L. Becker

Nerve injuries requiring surgery are a significant problem without good clinical alternatives to the autograft. Tissue engineering strategies are critically needed to provide an alternative. In this study, we utilized aligned nanofibers that were cli...

  • Article
  • Open Access
28 Citations
7,854 Views
13 Pages

Development of Highly pH-Sensitive Hybrid Membranes by Simultaneous Electrospinning of Amphiphilic Nanofibers Reinforced with Graphene Oxide

  • Mohsen Gorji,
  • Ali Sadeghianmaryan,
  • Hossein Rajabinejad,
  • Saman Nasherolahkam and
  • Xiongbiao Chen

Nanofibrous-based pH sensors have shown promise in a wide range of industrial and medical applications due to their fast response time and good mechanical properties. In the present study, we fabricated pH-sensitive sensors of nanofibrous membranes b...

  • Article
  • Open Access
14 Citations
7,059 Views
11 Pages

Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement

  • Luis Eduardo Schmidt,
  • Henrique Hadad,
  • Igor Rodrigues de Vasconcelos,
  • Luara Teixeira Colombo,
  • Rodrigo Capalbo da Silva,
  • Ana Flavia Piquera Santos,
  • Lara Cristina Cunha Cervantes,
  • Pier Paolo Poli,
  • Fabrizio Signorino and
  • Francisley Ávila Souza
  • + 2 authors

(1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in...

  • Article
  • Open Access
16 Citations
8,420 Views
28 Pages

In Vitro Characterization of Hypoxia Preconditioned Serum (HPS)—Fibrin Hydrogels: Basis for an Injectable Biomimetic Tissue Regeneration Therapy

  • Ektoras Hadjipanayi,
  • Philipp Moog,
  • Sanjar Bekeran,
  • Katharina Kirchhoff,
  • Andrei Berezhnoi,
  • Juan Aguirre,
  • Anna-Theresa Bauer,
  • Haydar Kükrek,
  • Daniel Schmauss and
  • Ulf Dornseifer
  • + 6 authors

Blood-derived growth factor preparations have long been employed to improve perfusion and aid tissue repair. Among these, platelet-rich plasma (PRP)-based therapies have seen the widest application, albeit with mixed clinical results to date. Hypoxia...

  • Article
  • Open Access
61 Citations
9,071 Views
15 Pages

Strontium and Zinc Substitution in β-Tricalcium Phosphate: An X-ray Diffraction, Solid State NMR and ATR-FTIR Study

  • Elisa Boanini,
  • Massimo Gazzano,
  • Carlo Nervi,
  • Michele R. Chierotti,
  • Katia Rubini,
  • Roberto Gobetto and
  • Adriana Bigi

β-tricalcium phosphate (β-TCP) is one of the most common bioceramics, widely applied in bone cements and implants. Herein we synthesized β-TCP by solid state reaction in the presence of increasing amounts of two biologically active ion...

  • Article
  • Open Access
9 Citations
8,950 Views
15 Pages

Accurate determination of the amount of glycosaminoglycans (GAGs) in a complex mixture of extracellular matrix (ECM) is important for tissue morphogenesis and homeostasis. The aim of the present study was to investigate an accurate, simple and sensit...

  • Feature Paper
  • Article
  • Open Access
21 Citations
9,478 Views
19 Pages

Adsorption of Proteins on m-CPPD and Urate Crystals Inhibits Crystal-Induced Cell Responses: Study on Albumin-Crystal Interaction

  • Felix Renaudin,
  • Stéphanie Sarda,
  • Laure Campillo-Gimenez,
  • Childérick Séverac,
  • Thibaut Léger,
  • Cédric Charvillat,
  • Christian Rey,
  • Frédéric Lioté,
  • Jean-Michel Camadro and
  • Christèle Combes
  • + 1 author

The biological effects and cellular activations triggered by monosodium urate (MSU) and calcium pyrophosphate dihydrate (monoclinic: m-CPPD) crystals might be modulated by protein coating on the crystal surface. This study is aimed at: (i) Identifyin...

  • Article
  • Open Access
76 Citations
12,556 Views
13 Pages

3D Printing Custom Bioactive and Absorbable Surgical Screws, Pins, and Bone Plates for Localized Drug Delivery

  • Karthik Tappa,
  • Udayabhanu Jammalamadaka,
  • Jeffery A. Weisman,
  • David H. Ballard,
  • Dallas D. Wolford,
  • Cecilia Pascual-Garrido,
  • Larry M. Wolford,
  • Pamela K. Woodard and
  • David K. Mills

Additive manufacturing has great potential for personalized medicine in osseous fixation surgery, including maxillofacial and orthopedic applications. The purpose of this study was to demonstrate 3D printing methods for the fabrication of patient-spe...

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J. Funct. Biomater. - ISSN 2079-4983