Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT
by
Marcus Hill 1,
Richard N. Cunningham 1,
Rania M. Hathout 2
,
Christopher Johnston 1,
John G. Hardy 3,4,* and
Marie E. Migaud 1,5,*
Marcus Hill 1,
Richard N. Cunningham 1,
Rania M. Hathout 2,
Christopher Johnston 1,
John G. Hardy 3,4,* and
Marie E. Migaud 1,5,*
1
School of Pharmacy, Queen’s University Belfast, Belfast BT7 1NN, UK
2
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
3
Department of Chemistry, Lancaster University, Lancaster, Lancashire LA1 4YB, UK
4
Materials Science Institute, Lancaster University, Lancaster, Lancashire LA1 4YB, UK
5
USA Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2019, 10(2), 26; https://doi.org/10.3390/jfb10020026
Received: 3 March 2019 / Revised: 22 May 2019 / Accepted: 10 June 2019 / Published: 13 June 2019
(This article belongs to the Special Issue Functional Biomaterials in Drug Delivery Applications)
Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant model bacteria (Pseudomonas aeruginosa) requires sufficient levels of therapeutic drug to maintain a drug concentration above the microbial inhibitory concentration (MIC) of the bacteria. Previous studies have shown that loading of aminoglycoside drugs in poly(lactic-co-glycolic) acid (PLGA)-based delivery systems is generally poor due to weak interactions between the drug and the polymer. The formation of complexes of tobramycin with dioctylsulfosuccinate (AOT) allows the effective loading of the drug in PLGA-nanoparticles and such nanoparticles can effectively deliver the antimicrobial aminoglycoside with retention of tobramycin antibacterial function.
View Full-Text
▼
Show Figures
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Hill, M.; Cunningham, R.N.; Hathout, R.M.; Johnston, C.; Hardy, J.G.; Migaud, M.E. Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT. J. Funct. Biomater. 2019, 10, 26.
Show more citation formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
- Supplementary File 1:
PDF-Document (PDF, 620 KB)
