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Journal of Clinical Medicine, Volume 9, Issue 7

July 2020 - 303 articles

Cover Story: Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTR) on their cell surface. The first-line pharmacological treatment for inoperable metastatic functioning well-differentiated NETs are somatostatin analogs. On second line, Lu-DOTA-TATE (177Lu-DOTA0 Tyr 3 octreotate) has shown stabilization of the disease and an increase in progression free survival, as well as effectiveness in controlling symptoms and increasing quality of life. The aim of this review is to establish practical guidance for the management and prevention of the most common hormonal crises during radionuclide treatment with Lu-DOTA-TATE: carcinoid syndrome (CS) and catecholamine hypersecretion, as well as to provide a brief commentary on other infrequent metabolic complications. To establish a practical approach, a systematic review was performed. View this paper
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Articles (303)

  • Article
  • Open Access
1 Citations
3,078 Views
16 Pages
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Optimizing Preparative Regimen for Umbilical Cord Blood Transplantation in Adult Acute Leukemia Patients: Acute Lymphoblastic Leukemia Requires Myeloablative Conditioning but Not Acute Myeloid Leukemia

  • Ja Min Byun,
  • Junshik Hong,
  • Doyeun Oh,
  • Ho-Young Yhim,
  • Young Rok Do,
  • Joon Seong Park,
  • Chul Won Jung,
  • Deok-Hwan Yang,
  • Jong-Ho Won and
  • Hong Ghi Lee
  • + 8 authors
J. Clin. Med.2020, 9(7), 2310;https://doi.org/10.3390/jcm9072310

21 July 2020

Cord blood transplantation (CBT) is a valuable alternative to bone marrow transplantation in adults without readily available donors. We conducted this study to investigate the feasibility of CBT for adult patients with acute leukemia with regards to...

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  • Article
  • Open Access
12 Citations
3,567 Views
12 Pages
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A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation

  • Silvia Gasteiger,
  • Valeria Berchtold,
  • Claudia Bösmüller,
  • Lucie Dostal,
  • Hanno Ulmer,
  • Christina Bogensperger,
  • Thomas Resch,
  • Michael Rudnicki,
  • Hannes Neuwirt and
  • Rupert Oberhuber
  • + 6 authors
J. Clin. Med.2020, 9(7), 2311;https://doi.org/10.3390/jcm9072311

21 July 2020

Hypothermic machine perfusion (HMP) has been introduced as an alternative to static cold storage (SCS) in kidney transplantation, but its true benefit in the clinical routine remains incompletely understood. The aim of this study was to assess the ef...

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  • Article
  • Open Access
37 Citations
7,868 Views
12 Pages
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The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study

  • Orianne Villard,
  • David Morquin,
  • Nicolas Molinari,
  • Isabelle Raingeard,
  • Nicolas Nagot,
  • Jean-Paul Cristol,
  • Boris Jung,
  • Camille Roubille,
  • Vincent Foulongne and
  • Pierre Fesler
  • + 11 authors
J. Clin. Med.2020, 9(7), 2315;https://doi.org/10.3390/jcm9072315

21 July 2020

Background. The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses the angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of the renin angiotensin aldosterone system (RAAS), as a cellular receptor to infect ce...

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  • Feature Paper
  • Review
  • Open Access
29 Citations
4,383 Views
15 Pages
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The Impact of the Extent of Surgery on the Long-Term Outcomes of Patients with Low-Risk Differentiated Non-Medullary Thyroid Cancer: A Systematic Meta-Analysis

  • Andreea Bojoga,
  • Anna Koot,
  • Johannes Bonenkamp,
  • Johannes de Wilt,
  • Joanna IntHout,
  • Peep Stalmeier,
  • Rosella Hermens,
  • Johannes Smit,
  • Petronella Ottevanger and
  • Romana Netea-Maier
J. Clin. Med.2020, 9(7), 2316;https://doi.org/10.3390/jcm9072316

21 July 2020

Recently, the management of patients with low-risk differentiated non-medullary thyroid cancer (DTC), including papillary and follicular thyroid carcinoma subtypes, has been critically appraised, questioning whether these patients might be overtreate...

Full Article
  • Review
  • Open Access
24 Citations
12,451 Views
12 Pages
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Management of Bleeding Events Associated with Antiplatelet Therapy: Evidence, Uncertainties and Pitfalls

  • Anne Godier,
  • Pierre Albaladejo and
  • the French Working Group on Perioperative Haemostasis (GIHP) Group
J. Clin. Med.2020, 9(7), 2318;https://doi.org/10.3390/jcm9072318

21 July 2020

Bleeding complications are common in patients treated with antiplatelet agents (APA), but their management relies on poor evidence. Therefore, practical guidelines and guidance documents are mainly based on expert opinion. The French Working Group on...

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  • Article
  • Open Access
4 Citations
3,099 Views
11 Pages
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Effects of Biofeedback Training on Esophageal Peristalsis in Amyotrophic Lateral Sclerosis Patients with Dysphagia

  • Jerzy Tomik,
  • Klaudia Sowula,
  • Piotr Ceranowicz,
  • Mateusz Dworak and
  • Kamila Stolcman
J. Clin. Med.2020, 9(7), 2314;https://doi.org/10.3390/jcm9072314

21 July 2020

Esophageal manometry (EM) could serve as an objective method for the detection of esophageal peristalsis in patients with amyotrophic lateral sclerosis (ALS). In this group of patients, biofeedback training (BT) using the EM procedure is a promising...

Full Article
  • Brief Report
  • Open Access
3 Citations
3,382 Views
17 Pages
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Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia

  • Irina Kholodnyuk,
  • Alla Rivkina,
  • Laura Hippe,
  • Simons Svirskis,
  • Svetlana Kozireva,
  • Ildze Ventina,
  • Irina Spaka,
  • Marina Soloveichika,
  • Jelena Pavlova and
  • Modra Murovska
  • + 1 author
J. Clin. Med.2020, 9(7), 2312;https://doi.org/10.3390/jcm9072312

21 July 2020

Chemokines and their receptors direct migration and infiltration of immune cells. CCR1 and CCR2 maintain sequence similarity and respond to a number of the same chemokines secreted in lymphoid organs. Expression of CD38 on leukemic cells has been ass...

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  • Article
  • Open Access
8 Citations
4,872 Views
11 Pages
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Inhaled Dry Powder Antibiotics in Patients with Non-Cystic Fibrosis Bronchiectasis: Efficacy and Safety in a Real-Life Study

  • Miguel Ángel Martínez-García,
  • Grace Oscullo,
  • Esther Barreiro,
  • Selene Cuenca,
  • Angela Cervera,
  • Alicia Padilla-Galo,
  • David de la Rosa,
  • Annie Navarro,
  • Rosa Giron and
  • Francisco Carbonero
  • + 2 authors
J. Clin. Med.2020, 9(7), 2317;https://doi.org/10.3390/jcm9072317

21 July 2020

Background: Nebulised antibiotics are habitually used in patients with bronchiectasis, but the use of dry powder inhaled antibiotics (DPIA) in these patients is extremely limited. This study seeks to analyse the efficacy and safety of DPIA in bronchi...

Full Article
  • Review
  • Open Access
27 Citations
8,376 Views
20 Pages
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Surgery and Perioperative Management in Small Intestinal Neuroendocrine Tumors

  • Sophie Deguelte,
  • Marine Perrier,
  • Cheryne Hammoutene,
  • Guillaume Cadiot and
  • Reza Kianmanesh
J. Clin. Med.2020, 9(7), 2319;https://doi.org/10.3390/jcm9072319

21 July 2020

Small-intestinal neuroendocrine tumors (SI-NETs) are the most prevalent small bowel neoplasms with an increasing frequency. In the multimodal management of SI-NETs, surgery plays a key role, either in curative intent, even if R0 resection is feasible...

Full Article
  • Article
  • Open Access
23 Citations
5,024 Views
11 Pages
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Genotype and Phenotype Analyses in Pediatric Patients with HNF1B Mutations

  • Seon Hee Lim,
  • Ji Hyun Kim,
  • Kyoung Hee Han,
  • Yo Han Ahn,
  • Hee Gyung Kang,
  • Il-Soo Ha and
  • Hae Il Cheong
J. Clin. Med.2020, 9(7), 2320;https://doi.org/10.3390/jcm9072320

21 July 2020

HNF1B mutations, one of the most common causes of congenital anomalies of the kidney and urinary tract, manifest as various renal and extrarenal phenotypes. We analyzed the genotype-phenotype correlations in 14 pediatric patients with HNF1B mutations...

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