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Special Issue "Cystic and Non-Cystic, Fibrosis Bronchiectasis: Drifting from Molecular to Clinical Practice"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: 25 December 2019

Special Issue Editors

Guest Editor
Dr. Adelina Amorim

1. Pulmonology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal
2. Faculty of Medicine, University of Porto, Porto, Portugal
Website | E-Mail
Interests: bronchiectasis; cystic fibrosis; chronic lung infections; non-tuberculosis mycobacteria
Guest Editor
Dr. Margarida Redondo

Pulmonology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal
Website | E-Mail
Interests: bronchiectasis; cystic fibrosis; chronic lung infections; non-invasive ventilation; neuromuscular diseases; sleep medicine
Guest Editor
Dr. David Araújo

Pulmonology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal
Website | E-Mail
Interests: bronchiectasis; chronic lung infections; non-tuberculosis mycobacteria; oncology; lung cancer
Guest Editor
Dr. Natália Martins

Faculty of Medicine, University of Porto – Portugal; Institute for Research and Inovation in Health (i3S), University of Porto - Portugal
E-Mail
Interests: evidence-based medicine; phytochemistry; phytopharmacology; drug discovery; natural products biochemistry; bioactive molecules; functional foods; nutraceuticals

Special Issue Information

Dear Colleagues,

In recent years, there has been increasing attention to non-cystic fibrosis (CF) bronchiectasis. For CF, the large number of studies performed in this area has led to a significant improvement in the overall life expectancy and quality of life of these patients, by using increasingly specific and effective therapeutic strategies. These advances, by allowing young patients to live longer and with better quality of life, present challenges to adulthood intervention.

On the other hand, non-CF bronchiectasis has been conceived of as one of the most neglected diseases in respiratory medicine. In fact, few studies have been done on this subject, so there is an urgent need to deepen our knowledge and address this complex chronic condition. In addition, the incidence of non-CF bronchiectasis is more frequent than what clinicians expected. Indeed, according to epidemiological data, a marked raise in bronchiectasis’ all-cause morbimortality has been stated, mainly due to multiple and recurrent exacerbations, triggered by complex infectious statuses and other complications. Thus, considering this scenario, there is an urgent need to carry out studies that allow us to more clearly understand the following: (1) the etiology underlying each case, since there is still a large percentage of patients considered idiopathic, and (2) the mechanisms associated with chronic infection and repetitive exacerbations, in order to find more effective strategies to combat them.

In this sense, all submissions addressing all of the above highlighted aspects on CF and non-CF bronchiectasis are welcome to this Special Issue. Thus, original articles, comprehensive and critical reviews, case reports, and even letters are of utmost interest, given the expansive scope of this area.

Dr. Adelina Amorim
Dr. Margarida Redondo
Dr. David Araújo
Dr. Natália Martins
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cystic fibrosis
  • Bronchiectasis
  • Chronic infections
  • Exacerbations
  • Quality of life
  • Therapeutic strategies
  • Epidemiology
  • Pulmonary rehabilitation
  • Inhaled therapy

Published Papers (1 paper)

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Research

Open AccessArticle
Chronic Bacterial Infection Prevalence, Risk Factors, and Characteristics: A Bronchiectasis Population-Based Prospective Study
J. Clin. Med. 2019, 8(3), 315; https://doi.org/10.3390/jcm8030315
Received: 15 February 2019 / Revised: 27 February 2019 / Accepted: 1 March 2019 / Published: 6 March 2019
PDF Full-text (272 KB) | HTML Full-text | XML Full-text
Abstract
Background: Few data are available on chronic bacterial infections (CBI) in bronchiectasis patients. Given that CBI seems to trigger longer hospital stays, worse outcomes, and morbimortality, this study was undertaken to assess CBI prevalence, characteristics, and risk factors in outpatients with bronchiectasis. Methods: [...] Read more.
Background: Few data are available on chronic bacterial infections (CBI) in bronchiectasis patients. Given that CBI seems to trigger longer hospital stays, worse outcomes, and morbimortality, this study was undertaken to assess CBI prevalence, characteristics, and risk factors in outpatients with bronchiectasis. Methods: A total of 186 patients followed in a bronchiectasis tertiary referral centre in Portugal were included. Demographic data and information on aetiology, smoking history, mMRC score, Bronchiectasis Severity Index (BSI) score, sputum characteristics, lung function, exacerbations, and radiological involvement degree were collected. Results: Patients included (mean age 54.7 ± 16.2 years; 60.8% females) were followed up for a period of 3.8 ± 1.7 years. The most common cause of bronchiectasis was infection (31.7%) followed by immune deficiencies (11.8%), whereas in 29% of cases, no cause was identified. Haemophilus influenzae (32.3%) and Pseudomonas aeruginosa (30.1%) were the most common CBI-associated possible pathogenic microorganisms. CBI patients presented a higher follow-up time than no-CBI patients (p = 0.003), worse lung function, BSI (p < 0.001), and radiological (p < 0.001) scores, and more prominent daily sputum production (p = 0.002), estimated mean volume (p < 0.001), and purulent sputum (p < 0.001). The number of exacerbations/year (p = 0.001), including those requiring hospital admission (p = 0.009), were also higher in the CBI group. Independent CBI predictors were BSI score (OR 3.577, 95% CI 1.233–10.378), sputum characteristics (OR 3.306, 95% CI 1.107–9.874), and radiological score (OR 1.052, 95% CI 1.004–1.102). Conclusion: According to the CBI status, two different sub-groups of patients were found on the basis of several clinical outcomes, emphasizing the importance of routine sputum microbiological monitoring. Further studies are needed to better characterize CBI profiles and to define the individual clinical impact of the most prevalent pathogenic microorganisms. Full article
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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