Special Issue "Platelet Counting, Morphology Assessment and Functional Studies: Pitfalls, Uncertainties, Good Practice for Clinical Usefulness"
Deadline for manuscript submissions: closed (30 June 2020).
Interests: haemostasis; platelet; laboratory haematology
Platelets are the professional, dedicated blood cells involved in (primary) hemostasis. Owing to their importance in many diseases, it does not come as a surprise that they have been frequently investigated in the hematology laboratory and at the bedside in daily practice and, over the years, the methods of these investigations have been greatly improved.
The investigation of primary hemostasis requires accurate platelet counting. Despite marked improvements, there remain several pitfalls, which are important to be taken into account and appropriately managed. Morphology assessment relies first and foremost on the optical microscope (blood smears), and need expertise and systematization, with adequate wording for the clinical use of the findings. Of course, more sophisticated approaches can be useful, EM of course (with a special note on whole mount preparations), but also confocal microscopy with fluorescent probes.
Platelet function studies encompass a broad range of methods, among which light transmission aggregometry remains the cornerstone despite its limitations (i.e., variability in methodology and interpretation). There are simplified (using whole blood) or by contrast highly sophisticated methods (i.e, studying platelets in under flow). POCT testing has become somewhat popular despite a clinical evaluation showing rather disappointing results. There is a lack of data regarding the sensitivity of these POCT tests to the platelet function. Flow cytometry has become an ever-increasing tool for platelet studies, not only for the expression of markers without and with activation, but also for accurate enumeration.
In this Special Issue, we will review methods for investigating the number, morphology, and functioning of blood platelets, focusing not only on the current standard, but also evaluating future applications and new perspectives. Much emphasis will be put on the clinical usefulness, and the everlasting need for good clinical studies to establish it, and on the current recommendations from different societies and groups. Original, review, and guidance/guidelines papers are welcome.
Prof. Dr. François Mullier
Prof. Dr. Thomas Lecompte
Manuscript Submission Information
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- Platelet count
- Platelet morphology
- Platelet functional tests
- Light transmission aggregometry
- Viscoelastic methods