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Journal of Clinical Medicine, Volume 9, Issue 2

February 2020 - 324 articles

Cover Story: Due to the great therapeutic interest involving the clinical translation of MSCs, they are being widely studied to determine their mechanism of action (MoA) in order to evaluate their efficacy, feasibility and safety in humans for the treatment of numerous pathologies. The therapeutic effects of MSCs compromise different mechanisms such as their capacity of migration and functional integration into diseased host tissue, their paracrine support and their impact on the regulation of both the innate and the acquired immune system. View this paper.
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Articles (324)

  • Article
  • Open Access
17 Citations
3,988 Views
12 Pages

A Mortality Prediction Rule for Hematology Patients with Invasive Aspergillosis Based on Serum Galactomannan Kinetics

  • Toine Mercier,
  • Joachim Wera,
  • Louis Y. A. Chai,
  • Katrien Lagrou and
  • Johan Maertens

24 February 2020

In invasive aspergillosis (IA), an early and adequate assessment of the response to the initial antifungal therapy remains problematic. We retrospectively analyzed 206 hematology patients with proven or probable IA, and collected serial serum galacto...

  • Article
  • Open Access
59 Citations
8,332 Views
11 Pages

Correlations between Sleep Bruxism and Temporomandibular Disorders

  • Brigitte Ohlmann,
  • Moritz Waldecker,
  • Michael Leckel,
  • Wolfgang Bömicke,
  • Rouven Behnisch,
  • Peter Rammelsberg and
  • Marc Schmitter

24 February 2020

The aim of this study was to identify correlations between sleep bruxism (SB) and temporomandibular disorders (TMD) as diagnosed by means of the research diagnostic criteria for temporomandibular disorders (RDC/TMD). Sleep bruxism was diagnosed on th...

  • Article
  • Open Access
159 Citations
19,949 Views
9 Pages

Short-term Forecasts of the COVID-19 Epidemic in Guangdong and Zhejiang, China: February 13–23, 2020

  • Kimberlyn Roosa,
  • Yiseul Lee,
  • Ruiyan Luo,
  • Alexander Kirpich,
  • Richard Rothenberg,
  • James M. Hyman,
  • Ping Yan and
  • Gerardo Chowell

22 February 2020

The ongoing COVID-19 epidemic continues to spread within and outside of China, despite several social distancing measures implemented by the Chinese government. Limited epidemiological data are available, and recent changes in case definition and rep...

  • Article
  • Open Access
5 Citations
4,966 Views
8 Pages

Radiosynoviorthesis after Surgery in the Treatment of Patients with Ankle Pigmented Villonodular Synovitis: A Case Series

  • Ioannis Iakovou,
  • Panagiotis Symeonidis,
  • Dimitrios Kotrotsios,
  • Evanthia Giannoula and
  • Christos Sachpekidis

22 February 2020

Pigmented villonodular synovitis (PVNS) of the ankle is a very rare, locally aggressive, proliferative disorder. Although surgical excision represents the standard curative treatment, the PVNS relapse rate is high. We present our study of five young...

  • Article
  • Open Access
6 Citations
5,201 Views
22 Pages

p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture

  • Aline Rangel-Pozzo,
  • Samuel Booth,
  • Pak Lok Ivan Yu,
  • Madhurendra Singh,
  • Galina Selivanova and
  • Sabine Mai

22 February 2020

The TP53 gene is a key tumor suppressor. Although the tumor suppressor p53 was one of the first to be characterized as a transcription factor, with its main function potentiated by its interaction with DNA, there are still many unresolved questions a...

  • Review
  • Open Access
79 Citations
9,159 Views
15 Pages

22 February 2020

Gestational diabetes mellitus (GDM) is a common condition with increasing prevalence worldwide. GDM is associated with an increased risk for maternal and neonatal complications. In this review we provide an overview of the most recent evidence on the...

  • Editorial
  • Open Access
129 Citations
44,504 Views
7 Pages

Communicating the Risk of Death from Novel Coronavirus Disease (COVID-19)

  • Tetsuro Kobayashi,
  • Sung-mok Jung,
  • Natalie M. Linton,
  • Ryo Kinoshita,
  • Katsuma Hayashi,
  • Takeshi Miyama,
  • Asami Anzai,
  • Yichi Yang,
  • Baoyin Yuan and
  • Andrei R. Akhmetzhanov
  • + 2 authors

21 February 2020

To understand the severity of infection for a given disease, it is common epidemiological practice to estimate the case fatality risk, defined as the risk of death among cases. However, there are three technical obstacles that should be addressed to...

  • Article
  • Open Access
8 Citations
3,811 Views
11 Pages

Efficacy of Low-Dose Radioiodine Ablation in Low- and Intermediate-Risk Differentiated Thyroid Cancer: A Retrospective Comparative Analysis

  • Ana María Gómez-Pérez,
  • Jorge García-Alemán,
  • María Molina-Vega,
  • Arantzazu Sebastián Ochoa,
  • Pilar Pérez García,
  • Isabel Mancha Doblas and
  • Francisco J Tinahones

21 February 2020

(1) Background—low-dose radioiodine ablation is an accepted strategy for the treatment of low- and intermediate-risk thyroid carcinomas, although there is no international consensus. The aim of this study is to describe the clinical experience...

  • Article
  • Open Access
42 Citations
4,691 Views
14 Pages

A Population-Based Study of Diabetes during Pregnancy in Spain (2009–2015): Trends in Incidence, Obstetric Interventions, and Pregnancy Outcomes

  • Ana López-de-Andrés,
  • Napoleón Perez-Farinos,
  • Valentín Hernández-Barrera,
  • María A. Palomar-Gallego,
  • David Carabantes-Alarcón,
  • José J. Zamorano-León,
  • Javier De Miguel-Diez and
  • Rodrigo Jimenez-Garcia

21 February 2020

(1) Background: We examined trends in incidence and outcomes in women with existing type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM) compared with a control group without diabetes. (2) Methods:...

  • Article
  • Open Access
8 Citations
3,630 Views
11 Pages

High Platelet Reactivity after Transition from Cangrelor to Ticagrelor in Hypothermic Cardiac Arrest Survivors with ST-Segment Elevation Myocardial Infarction

  • Nina Buchtele,
  • Harald Herkner,
  • Christian Schörgenhofer,
  • Anne Merrelaar,
  • Roberta Laggner,
  • Georg Gelbenegger,
  • Alexander O. Spiel,
  • Hans Domanovits,
  • Irene Lang and
  • Bernd Jilma
  • + 1 author

21 February 2020

Transition from cangrelor to oral P2Y12 inhibitors after PCI carries the risk of platelet function recovery and acute stent thrombosis. Whether the recommended transition regimen is appropriate for hypothermic cardiac arrest survivors is unknown. We...

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J. Clin. Med. - ISSN 2077-0383