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Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use

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Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, 18016 Granada, Spain
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Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain
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Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, 18016 Granada, Spain
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Excellence Research Unit “Modeling Nature” (MNat), University of Granada, 18016 Granada, Spain
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Department of Health Sciences, University of Jaén, 23071 Jaén, Spain
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Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18016 Granada, Spain
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R&D Human Health, Bioibérica S.A.U., 08029 Barcelona, Spain
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Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 445; https://doi.org/10.3390/jcm9020445
Received: 3 January 2020 / Revised: 25 January 2020 / Accepted: 30 January 2020 / Published: 6 February 2020
(This article belongs to the Section Clinical Cytology)
Due to the great therapeutic interest that involves the translation of mesenchymal stromal cells (MSCs) into clinical practice, they have been widely studied as innovative drugs, in order to treat multiple pathologies. MSC-based cell therapy involves the administration of MSCs either locally or systemically into the receptor body where they can traffic and migrate towards the affected tissue and participate in the process of healing. The therapeutic effects of MSCs compromise of different mechanisms such as the functional integration of differentiated MSCs into diseased host tissue after transplantation, their paracrine support, and their impact on the regulation of both the innate and the acquired immune system. Here, we establish and provide recent advances about the principal mechanisms of action through which MSCs can perform their activity and effect as a therapeutic tool. The purpose of this review is to examine and discuss the MSCs capacity of migration, their paracrine effect, as well as MSC-mediated modifications on immune cell responses. View Full-Text
Keywords: mesenchymal stromal cells; mechanism of action; homing; immunomodulation mesenchymal stromal cells; mechanism of action; homing; immunomodulation
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MDPI and ACS Style

Jimenez-Puerta, G.J.; Marchal, J.A.; López-Ruiz, E.; Gálvez-Martín, P. Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use. J. Clin. Med. 2020, 9, 445.

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