Next Article in Journal
p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture
Previous Article in Journal
Short-term Forecasts of the COVID-19 Epidemic in Guangdong and Zhejiang, China: February 13–23, 2020
 
 
Article

Radiosynoviorthesis after Surgery in the Treatment of Patients with Ankle Pigmented Villonodular Synovitis: A Case Series

1
Academic Department of Nuclear Medicine, School of Medicine, University Hospital AHEPA, 54621 Thessaloniki, Greece
2
Department of Nuclear Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, 57006 Thessaloniki, Greece
3
Department of Orthopedics, St. Luke’s Hospital, 55236 Thessaloniki, Greece
4
Department of Nuclear Medicine, Inselspital, Bern University Hospital, 3010 Bern, Switzerland
5
Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 597; https://doi.org/10.3390/jcm9020597
Received: 23 January 2020 / Revised: 14 February 2020 / Accepted: 19 February 2020 / Published: 22 February 2020
(This article belongs to the Section Orthopedics)
Pigmented villonodular synovitis (PVNS) of the ankle is a very rare, locally aggressive, proliferative disorder. Although surgical excision represents the standard curative treatment, the PVNS relapse rate is high. We present our study of five young athletes (range 20–36 years) with a histopathological diagnosis of PVNS of the ankle, who were treated by surgery and adjuvant radiosynoviorthesis (RSO). The operation involved either arthroscopic (four patients) or open (one patient) debridement, followed by intraarticular RSO with the radiopharmaceutical erbium-169 (169Er). They were evaluated with the Foot Function Index (FFI) and a visual analog scale (VAS) for pain. At a median follow up period of 47 months (range 36–54 months), all five patients reported marked pain relief with improvements in their daily activities. In particular, the median FFI decreased from 77% (range 71.0%–84.5%) pre-treatment, to 0.5% (range 0%–6%) after treatment. The median VAS score decreased from 4 (range 3–7) to 0 (range 0–1), respectively. Throughout the follow-up period, there were no major complications regarding either therapeutic intervention (arthroscopic or open debridement, RSO). Based on these results, it can be concluded that adjuvant RSO with 169Er following surgical excision is effective and safe in the treatment of PVNS of the ankle. View Full-Text
Keywords: ankle pigmented villonodular synovitis (PVNS); radiosynoviorthesis (RSO); erbium-169 (169Er) ankle pigmented villonodular synovitis (PVNS); radiosynoviorthesis (RSO); erbium-169 (169Er)
Show Figures

Figure 1

MDPI and ACS Style

Iakovou, I.; Symeonidis, P.; Kotrotsios, D.; Giannoula, E.; Sachpekidis, C. Radiosynoviorthesis after Surgery in the Treatment of Patients with Ankle Pigmented Villonodular Synovitis: A Case Series. J. Clin. Med. 2020, 9, 597. https://doi.org/10.3390/jcm9020597

AMA Style

Iakovou I, Symeonidis P, Kotrotsios D, Giannoula E, Sachpekidis C. Radiosynoviorthesis after Surgery in the Treatment of Patients with Ankle Pigmented Villonodular Synovitis: A Case Series. Journal of Clinical Medicine. 2020; 9(2):597. https://doi.org/10.3390/jcm9020597

Chicago/Turabian Style

Iakovou, Ioannis, Panagiotis Symeonidis, Dimitrios Kotrotsios, Evanthia Giannoula, and Christos Sachpekidis. 2020. "Radiosynoviorthesis after Surgery in the Treatment of Patients with Ankle Pigmented Villonodular Synovitis: A Case Series" Journal of Clinical Medicine 9, no. 2: 597. https://doi.org/10.3390/jcm9020597

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop