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Journal of Clinical Medicine, Volume 14, Issue 13

July-1 2025 - 424 articles

Cover Story: Venous thromboembolism (VTE) is a major source of preventable morbidity in neurocritically ill patients, yet the optimal timing and agent for pharmacologic thromboprophylaxis (PTP) remain uncertain. In this review of 90 studies, including 669,725 patients with traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, or spinal cord injury, or those requiring neurosurgical intervention, early PTP (within 24–72 hours) was generally associated with reduced VTE risk without a consistently increased risk of bleeding. Enoxaparin showed potential benefits over unfractionated heparin in certain subgroups. Safety may be improved in some injury types, with early repeat imaging suggesting stable bleeding. Despite variability in study designs and quality, this updated assessment of the literature supports early, individualized PTP strategies. View this paper
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Articles (424)

  • Systematic Review
  • Open Access
4 Citations
1,246 Views
14 Pages

6 July 2025

Background: Epicardial adipose tissue (EAT) may contribute to the pathogenesis of atrial fibrillation (AF). The attenuation of EAT assessed by means of computed tomography (CT) may reflect the severity of local tissue inflammation. This study aimed t...

  • Article
  • Open Access
2,619 Views
12 Pages

Hashimoto’s Thyroiditis and Female Infertility: A Clinical and Statistical Investigation of Endocrine and Ovarian Markers

  • Emilia Cristina Popa,
  • Laura Maghiar,
  • Teodor Andrei Maghiar,
  • Ilarie Brihan,
  • Laura Monica Georgescu,
  • Bianca Anamaria Toderaș,
  • Liliana Sachelarie,
  • Loredana Liliana Hurjui and
  • Anca Huniadi

6 July 2025

Background: Hashimoto’s thyroiditis (HT), the most prevalent autoimmune thyroid disorder in reproductive-age women, has been linked to diminished ovarian reserve and subfertility. This study aimed to evaluate the relationship between HT and key...

  • Article
  • Open Access
891 Views
10 Pages

5 July 2025

Background/Objectives: This study evaluates the structural strength of various fixation models for distal tibial fractures using finite element analysis, comparing the biomechanical performance of different interlocking and blocking screw configurati...

  • Systematic Review
  • Open Access
1 Citations
2,258 Views
25 Pages

Paternity After Treatment of Cryptorchidism: A Systematic Review

  • Anna Lund Henriksen,
  • Ida-Marie Poulsen,
  • Freja Sørensen and
  • Jens Fedder

5 July 2025

Background: Male infertility can arise from various causes, accounting for 30–50% of infertility cases. The aim of this systematic review is to establish paternity outcomes in men treated for cryptorchidism during childhood, and to evaluate the...

  • Systematic Review
  • Open Access
2 Citations
2,562 Views
53 Pages

Hypersensitivity in Orthodontics: A Systematic Review of Oral and Extra-Oral Reactions

  • Alessandra Amato,
  • Stefano Martina,
  • Giuseppina De Benedetto,
  • Ambrosina Michelotti,
  • Massimo Amato and
  • Federica Di Spirito

5 July 2025

Background/Objectives: This systematic review analyzed the epidemiologic and macro/microscopic features of manifestations of hypersensitivity reactions with oral and extra-oral involvement in orthodontic patients with fixed (FAs) or removable (RAs) a...

  • Article
  • Open Access
3 Citations
758 Views
20 Pages

Comprehensive Assessment of Biventricular and Biatrial Myocardial Strain Parameters at Six Years Postpartum in a Cohort of Women with Previous Hypertensive Disorders of Pregnancy

  • Andrea Sonaglioni,
  • Federico Napoli,
  • Rebecca Dell’Anna,
  • Gian Luigi Nicolosi,
  • Stefano Bianchi,
  • Michele Lombardo,
  • Sergio Harari and
  • Chiara Lonati

5 July 2025

Background: Over the past decade, few echocardiographic investigations have assessed myocardial strain parameters in women with a history of hypertensive disorders of pregnancy (HDP), and their findings have been inconsistent. Moreover, no study has...

  • Systematic Review
  • Open Access
1 Citations
6,962 Views
16 Pages

5 July 2025

Background/Objective: The objective of this study is to compare the relative effectiveness of combination therapy (exercise plus manual therapy) versus single-modality physiotherapy interventions for improving pain and function in patients with rotat...

  • Article
  • Open Access
571 Views
10 Pages

Factors Associated with Employment in a Cohort of Patients with Systemic Sclerosis

  • Cristina A. Vrancianu,
  • Cristiana Grigore,
  • Ioan Ancuta,
  • Mihai Bojinca and
  • Ana Maria Gheorghiu

5 July 2025

Background/Objectives: Systemic sclerosis (SSc) is a multisystemic chronic autoimmune disease, which leads to disability and possibly early retirement. The objective of our study was to explore the associations between employment status (ES) and demo...

  • Case Report
  • Open Access
1 Citations
1,366 Views
13 Pages

Complicated Diagnosis and Treatment of Rare Painless Acanthamoeba Keratitis

  • Dominika Wróbel-Dudzińska,
  • Marta Ziaja-Sołtys,
  • Beata Rymgayłło-Jankowska,
  • Monika Derda,
  • Robert Klepacz,
  • Daniel Zalewski,
  • Tomasz Żarnowski and
  • Anna Bogucka-Kocka

5 July 2025

Objectives: The aim was to present the complicated diagnostic and therapeutic process of atypical, painless keratitis caused by a cosmopolitan protozoan of the genus Acanthamoeba. Methods: This Case Report describes a medical case involving a 48-year...

  • Article
  • Open Access
683 Views
13 Pages

Three-Dimensional Transesophageal Echocardiography Is Useful for Preventing Prosthetic-Patient Mismatch After Surgical Aortic Valve Replacement

  • Kazuki Yoshida,
  • Haruka Sasaki,
  • Hiroyuki Takaoka,
  • Moe Matsumoto,
  • Yusei Nishikawa,
  • Yoshitada Noguchi,
  • Shuhei Aoki,
  • Katsuya Suzuki,
  • Satomi Yashima and
  • Makiko Kinoshita
  • + 5 authors

5 July 2025

Introduction: Prosthesis-patient mismatch (PPM) in surgical aortic valve replacement (SAVR) is known to be a poor prognostic factor. However, the parameters for preventing postoperative PPM in SAVR have not been established. Materials and Methods: Tw...

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J. Clin. Med. - ISSN 2077-0383