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Journal of Clinical Medicine, Volume 14, Issue 13

July-1 2025 - 424 articles

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Cover Story: Venous thromboembolism (VTE) is a major source of preventable morbidity in neurocritically ill patients, yet the optimal timing and agent for pharmacologic thromboprophylaxis (PTP) remain uncertain. In this review of 90 studies, including 669,725 patients with traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, or spinal cord injury, or those requiring neurosurgical intervention, early PTP (within 24–72 hours) was generally associated with reduced VTE risk without a consistently increased risk of bleeding. Enoxaparin showed potential benefits over unfractionated heparin in certain subgroups. Safety may be improved in some injury types, with early repeat imaging suggesting stable bleeding. Despite variability in study designs and quality, this updated assessment of the literature supports early, individualized PTP strategies. View this paper

Articles (424)

  • Review
  • Open Access
1,337 Views
16 Pages

Hepatitis C—Everything a Primary Care Physician Needs to Know About Diagnosis, Management, and Follow-Up

  • Sindhuri Benjaram,
  • Shweta Kapur,
  • Anusha McKay,
  • Mohamad Khaled Almujarkesh,
  • Kassandra S. Carter,
  • Alexandra Picardal,
  • Diane Levine and
  • Prateek Lohia

7 July 2025

Hepatitis C virus (HCV) infection is a major public health concern, with more than 58 million people chronically infected worldwide. The management of HCV, once the domain of specialists only, has been revolutionized by the advent of direct-acting an...

  • Systematic Review
  • Open Access
1 Citations
3,657 Views
15 Pages

7 July 2025

Background: The aim of this review was to analyze training interventions used and their effectiveness in improving pelvic floor muscle function related to urinary continence in postmenopausal women. We then characterized the recommended pelvic floor...

  • Article
  • Open Access
942 Views
13 Pages

Correlation Between Dental Health and Aesthetic Components of Malocclusion in Junior High and High School Students: An Epidemiological Study Using Item Response Theory

  • Hiromi Sato,
  • Yudai Shimpo,
  • Toshiko Sekiya,
  • Haruna Rikitake,
  • Minami Seki,
  • Satoshi Wada,
  • Yoshiaki Nomura and
  • Hiroshi Tomonari

7 July 2025

Background: The Index of Orthodontic Treatment Need (IOTN) is widely used to assess the need for orthodontic treatment. IOTN consists of the Dental Health Component (DHC) and the Aesthetic Component (AC), evaluating malocclusion morphologically and a...

  • Article
  • Open Access
726 Views
16 Pages

Comparison of Magnetic Resonance Imaging Scales for Assessment of Interval Changes of Arthropathy in Boys with Severe Hemophilia

  • Ningning Zhang,
  • Manuel Carcao,
  • Danial M. Ignas,
  • Brian M. Feldman,
  • Pamela Hilliard,
  • Rahim Moineddin,
  • Ann Marie Stain,
  • Paul Babyn,
  • Victor S. Blanchette and
  • Andrea S. Doria

7 July 2025

Background/Objectives: The variety of magnetic resonance imaging (MRI) scales available to measure soft tissue and osteochondral changes in joints of persons with hemophilia poses challenges in evaluating published clinical/research studies. To evalu...

  • Article
  • Open Access
915 Views
17 Pages

Clinical Predictors of Inpatient Mortality and Poor Postoperative Course After aSAH Microsurgical Clipping: A 10-Year Experience from a Peruvian Tertiary Care Center

  • Fernando Terry,
  • Alejandro Enríquez-Marulanda,
  • Nathaly Chinchihualpa-Paredes,
  • Meiling Carbajal-Galarza,
  • Claudia L Vidal-Cuellar,
  • Guiliana Mas-Ubillus,
  • Bruno Diaz-Llanes,
  • Carlos Quispe-Vicuña,
  • Niels Pacheco-Barrios and
  • Rommel Arbulu-Zuazo
  • + 6 authors

7 July 2025

Background/Objectives: Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency with a high mortality rate requiring urgent treatment. This study aimed to identify clinical predictors of inpatient mortality and poor postoperative course after...

  • Article
  • Open Access
1 Citations
865 Views
13 Pages

7 July 2025

Background: Acute Aortic Syndrome (AAS), encompassing aortic dissection (AD), intramural hematoma (IMH), and penetrating atherosclerotic ulcer (PAU), presents diagnostic challenges due to its varied manifestations and the critical need for rapid asse...

  • Article
  • Open Access
3,217 Views
14 Pages

E-Gastryal® + Magnesium Alginate Plus PPI vs. PPI Alone in GERD: Results from the GENYAL® Randomized Controlled Trial

  • Cristiano Spada,
  • Daniele Salvi,
  • Silvia Pecere,
  • Francesca Mangiola,
  • Simone Varca,
  • Serban Rosu,
  • Vora Prateek,
  • Petru Vasile Ciobanca,
  • Adrian Goldis and
  • Dionisio Franco Barattini
  • + 1 author

7 July 2025

Background: Up to one-third of patients with gastroesophageal reflux disease (GERD) have persistent symptoms despite proton-pump inhibitor (PPI) therapy. E-Gastryal® + MgAlg (Aurora Biofarma, Italy) is a mucosal protective agent that enhances bar...

  • Review
  • Open Access
2,430 Views
22 Pages

Narrative and Pictorial Review on State-of-the-Art Endovascular Treatment for Focal Non-Infected Lesions of the Abdominal Aorta: Anatomical Challenges, Technical Solutions, and Clinical Outcomes

  • Mario D’Oria,
  • Marta Ascione,
  • Paolo Spath,
  • Gabriele Piffaretti,
  • Enrico Gallitto,
  • Wassim Mansour,
  • Antonino Maria Logiacco,
  • Giovanni Badalamenti,
  • Antonio Cappiello and
  • Giulia Moretti
  • + 4 authors

7 July 2025

The natural history of focal non-infected lesions of the abdominal aorta (fl-AA) remains unclear and largely depends on their aetiology. These lesions often involve a focal “tear” or partial disruption of the arterial wall. Penetrating ao...

  • Article
  • Open Access
1,492 Views
20 Pages

7 July 2025

Background: Intra-aortic balloon pump (IABP) augments coronary perfusion during high-risk percutaneous coronary interventions (PCI). We sought to identify patients who benefited from prophylactic IABP (P-IABP) compared to rescue-IABP (R-IABP). Method...

  • Review
  • Open Access
1 Citations
3,581 Views
18 Pages

The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights

  • Andreas Mitsis,
  • Stefanos Sokratous,
  • Georgia Karmioti,
  • Michaela Kyriakou,
  • Michail Drakomathioulakis,
  • Michael M. Myrianthefs,
  • Christos Eftychiou,
  • Nikolaos P. E. Kadoglou,
  • Stergios Tzikas and
  • Nikolaos Fragakis
  • + 1 author

7 July 2025

C-reactive protein (CRP) has emerged as a valuable biomarker in acute myocardial infarction (AMI), offering multiple insights into diagnosis, prognosis, and therapeutic strategies. In the diagnostic domain, elevated CRP levels serve as an early indic...

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J. Clin. Med. - ISSN 2077-0383Creative Common CC BY license