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Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy

by 1,2,3, 1,2,3, 1,2,3,4 and 1,2,3,*
1
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Escola d’Enginyeria Barcelona Est (EEBE), Universitat Politècnica de Catalunya (UPC), 08930 Barcelona, Spain
2
Barcelona Research Center in Multiscale Science and Engineering, UPC, 08930 Barcelona, Spain
3
Research Centre for Biomedical Engineering (CREB), UPC, 08034 Barcelona, Spain
4
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08034 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: David Creytens
J. Clin. Med. 2021, 10(4), 893; https://doi.org/10.3390/jcm10040893
Received: 25 January 2021 / Revised: 10 February 2021 / Accepted: 15 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue Novel Pathogenic Mechanisms and Therapeutic Approaches for Sarcomas)
Osteosarcoma is the most common primary bone tumor, and its first line of treatment presents a high failure rate. The 5-year survival for children and teenagers with osteosarcoma is 70% (if diagnosed before it has metastasized) or 20% (if spread at the time of diagnosis), stressing the need for novel therapies. Recently, cold atmospheric plasmas (ionized gases consisting of UV–Vis radiation, electromagnetic fields and a great variety of reactive species) and plasma-treated liquids have been shown to have the potential to selectively eliminate cancer cells in different tumors through an oxidative stress-dependent mechanism. In this work, we review the current state of the art in cold plasma therapy for osteosarcoma. Specifically, we emphasize the mechanisms unveiled thus far regarding the action of plasmas on osteosarcoma. Finally, we review current and potential future approaches, emphasizing the most critical challenges for the development of osteosarcoma therapies based on this emerging technique. View Full-Text
Keywords: osteosarcoma; cold atmospheric plasma; plasma treated liquids; reactive oxygen and nitrogen species; oxidative stress; tumor microenvironment; cancer stem cells osteosarcoma; cold atmospheric plasma; plasma treated liquids; reactive oxygen and nitrogen species; oxidative stress; tumor microenvironment; cancer stem cells
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MDPI and ACS Style

Mateu-Sanz, M.; Tornín, J.; Ginebra, M.-P.; Canal, C. Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy. J. Clin. Med. 2021, 10, 893. https://doi.org/10.3390/jcm10040893

AMA Style

Mateu-Sanz M, Tornín J, Ginebra M-P, Canal C. Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy. Journal of Clinical Medicine. 2021; 10(4):893. https://doi.org/10.3390/jcm10040893

Chicago/Turabian Style

Mateu-Sanz, Miguel; Tornín, Juan; Ginebra, Maria-Pau; Canal, Cristina. 2021. "Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy" J. Clin. Med. 10, no. 4: 893. https://doi.org/10.3390/jcm10040893

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