Recurrent Pregnancy Loss: Etiology, Diagnosis, and Therapy
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 76176
Special Issue Editor
Interests: recurrent pregnancy loss; reproductive immunology; recurrent miscarriage
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recurrent pregnancy loss, defined as a minimum of 2 or 3 consecutive miscarriages or biochemical losses, affects 1%–3% of women in fertile age, and the incidence may be increasing. The psychological impact in the affected women is substantial. Very few proven causal factors exist, whereas many risk factors have been reported; these risk factors probably act together in a multifactorial way to cause recurrent pregnancy loss. Important risk factors are immune dysfunction, including autoimmunity, thrombophilia, endocrine dysfunction, and obesity. It is important to realize that in recurrent pregnancy loss patients, half of the pregnancy losses are also caused by embryonal aneuploidy. Plenty of studies have documented that recurrent pregnancy loss patients have an increased risk of various obstetrical and perinatal complications, such as low birth weight, preterm delivery, and placental abruption in ongoing pregnancies, suggesting that early- and late-pregnancy complications associated with placental dysfunction have overlapping etiologies.
No treatment of recurrent pregnancy loss is well-documented. The best documented treatments are heparin and low-dose aspirin in patients with the antiphospholipid syndrome, vaginal micronized progesterone in patients with 3 or more miscarriages, and intravenous immunoglobulin in patients with secondary recurrent pregnancy loss. In order to optimize management of recurrent pregnancy loss patients, monitoring of results of individual clinics on the national or international level should be implemented.
Prof. Dr. Ole Bjarne Christiansen
Guest Editor
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Keywords
- Recurrent pregnancy loss
- Miscarriage
- Reproductive immunology
- Antiphospholipid syndrome
- Low birthweight
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