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Journal of Clinical Medicine, Volume 10, Issue 2

January-2 2021 - 207 articles

Cover Story: Endothelial dysfunction is a primary feature of several cardiovascular diseases. Endothelial colony-forming cells (ECFCs) represent a highly proliferative subtype of endothelial progenitor cells (EPCs), which are involved in neovascularization and vascular repair. Statins are known to improve the outcome of cardiovascular diseases via pleiotropic effects. Pravastatin induced effects were reversible by the addition of mevalonate. Pravastatin induces beneficial effects on ECFC function, angiogenic signaling and protein expression. These effects may contribute to understand the pleiotropic function of statins as well as to provide a promising option to improve ECFCs’ condition in cell therapy in order to ameliorate endothelial dysfunction. View this paper
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Articles (207)

  • Review
  • Open Access
27 Citations
4,175 Views
13 Pages

19 January 2021

Hepatocellular carcinoma (HCC) incidence has dramatically decreased in patients infected with HCV and HBV due to the widespread use of highly effective antiviral agents. Nevertheless, a substantial proportion of patients with advanced fibrosis or cir...

  • Article
  • Open Access
15 Citations
3,733 Views
12 Pages

Cardiovascular Risk Factors and Their Relationship with Vascular Dysfunction in South African Children of African Ancestry

  • Edna N. Matjuda,
  • Godwill A. Engwa,
  • Samuel Nkeh Chungag Anye,
  • Benedicta N. Nkeh-Chungag and
  • Nandu Goswami

19 January 2021

Vascular dysfunction is known to be an initiator of the development and progression of cardiovascular diseases (CVDs). However, there is paucity of information on the relationship of vascular dysfunction with cardiovascular risk factors in children o...

  • Review
  • Open Access
22 Citations
5,034 Views
10 Pages

Laser Interstitial Thermal Therapy in Patients with Newly Diagnosed Glioblastoma: A Systematic Review

  • Ilaria Viozzi,
  • Alis Guberinic,
  • Christiaan G. Overduin,
  • Maroeska M. Rovers and
  • Mark ter Laan

19 January 2021

Background: Laser interstitial thermal therapy (LITT) is a minimal invasive neurosurgical technique for the treatment of brain tumors. Results of LITT have been reported in a case series of patients with deep seated and/or recurrent glioblastoma or c...

  • Article
  • Open Access
26 Citations
3,926 Views
11 Pages

19 January 2021

(1) Background: Epi- and Paracardial Adipose Tissue (EAT, PAT) have been spotlighted as important biomarkers in cardiological assessment in recent years. Since biomarker quantification is an increasingly important method for clinical use, we wanted t...

  • Article
  • Open Access
4 Citations
2,793 Views
11 Pages

19 January 2021

Background: The acute physiological changes induced by focal retinal photocoagulation (PC) have been largely unexplored. Methods: This was a case-series study. We recorded multifocal electroretinograms (mfERGs) just before PC, and mfERGs were also re...

  • Article
  • Open Access
156 Citations
11,973 Views
12 Pages

Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity

  • Trinidad Montero-Vilchez,
  • María-Victoria Segura-Fernández-Nogueras,
  • Isabel Pérez-Rodríguez,
  • Miguel Soler-Gongora,
  • Antonio Martinez-Lopez,
  • Ana Fernández-González,
  • Alejandro Molina-Leyva and
  • Salvador Arias-Santiago

19 January 2021

Multiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objec...

  • Review
  • Open Access
17 Citations
4,520 Views
19 Pages

The Profile of the Obstetric Patients with SARS-CoV-2 Infection According to Country of Origin of the Publication: A Systematic Review of the Literature

  • Yolanda Cuñarro-López,
  • Pilar Pintado-Recarte,
  • Ignacio Cueto-Hernández,
  • Concepción Hernández-Martín,
  • María Pilar Payá-Martínez,
  • María del Mar Muñóz-Chápuli,
  • Óscar Cano-Valderrama,
  • Coral Bravo,
  • Julia Bujan and
  • Melchor Álvarez-Mon
  • + 2 authors

19 January 2021

SARS-CoV-2 is the novel member of coronavirus responsible for the worldwide pandemic COVID-19, affecting all types of people. In this context, established research identified pregnant women as a susceptible group of SARS-CoV-2 infection, although the...

  • Article
  • Open Access
13 Citations
3,767 Views
10 Pages

Low Luminance Visual Acuity and Low Luminance Deficit in Proliferative Diabetic Retinopathy

  • Eleni Karatsai,
  • Piyali Sen,
  • Sarega Gurudas and
  • Sobha Sivaprasad

19 January 2021

This study aimed to determine the relation of best corrected visual acuity (BCVA) and low luminance visual acuity (LLVA) in proliferative diabetic retinopathy (PDR) following treatment with either aflibercept or pan-retinal photocoagulation (PRP). Th...

  • Article
  • Open Access
4 Citations
2,766 Views
11 Pages

Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [18F]FDG PET/CT

  • Filipe Montes de Jesus,
  • Vibeke Vergote,
  • Walter Noordzij,
  • Daan Dierickx,
  • Rudi Dierckx,
  • Arjan Diepstra,
  • Thomas Tousseyn,
  • Olivier Gheysens,
  • Thomas Kwee and
  • Christophe Deroose
  • + 1 author

19 January 2021

Background: Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation classified according to the WHO as nondestructive, polymorphic, monomorphic, and classic Hodgkin Lymphoma subtypes. In this retrospective study...

  • Review
  • Open Access
84 Citations
30,295 Views
16 Pages

Dermatological Manifestations in Inflammatory Bowel Diseases

  • Elisabetta Antonelli,
  • Gabrio Bassotti,
  • Marta Tramontana,
  • Katharina Hansel,
  • Luca Stingeni,
  • Sandro Ardizzone,
  • Giovanni Genovese,
  • Angelo Valerio Marzano and
  • Giovanni Maconi

19 January 2021

Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disea...

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J. Clin. Med. - ISSN 2077-0383