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Vaccines, Volume 9, Issue 8

August 2021 - 135 articles

Cover Story: The humoral and cellular immunogenicity of a candidate DNA vaccine expressing the subunit 1 (S1) of the spike protein from SARS-CoV-2 (pVAX-S1) was evaluated in BALB/c mice. Upon intramuscular administration using a needle-free system, three doses of 50 µg from pVAX-S1 elicited high titers of SARS-CoV-2 specific binding IgG and neutralizing antibodies. Analysis of IgG subclasses showed a Th1-polarized immune response as demonstrated by the significant elevation of S1-specific IgG2a and IgG2b compared to IgG1, which was further supported by the significantly high levels of polyfunctional S1- specific memory CD4+ and CD8+ T cells. These data suggest that pVAX-S1 is immunogenic and merits further preclinical and clinical testing. View this paper.
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Articles (135)

  • Article
  • Open Access
18 Citations
4,266 Views
11 Pages

23 August 2021

Background: The research focused on the relationships between attitudes towards vaccination and the trust placed in different sources of information (science, experts and the information available on the Internet) before and during COVID-19. Method:...

  • Review
  • Open Access
41 Citations
6,519 Views
23 Pages

23 August 2021

Engineering polymeric nanoparticles for their shape, size, surface chemistry, and functionalization using various targeting molecules has shown improved biomedical applications for nanoparticles. Polymeric nanoparticles have created tremendous therap...

  • Feature Paper
  • Article
  • Open Access
7 Citations
3,344 Views
19 Pages

Characterization of Membrane-Associated Progesterone Receptor Component-2 (MAPRC2) from Trichinella spiralis and Its Interaction with Progesterone and Mifepristone

  • Muhammad Tahir Aleem,
  • Jiawen Shi,
  • Zhengqing Yu,
  • Zhaohai Wen,
  • Yang Zhang,
  • Meng Liang,
  • Shakeel Ahmed Lakho,
  • Muhammad Haseeb,
  • Haider Ali and
  • Ruofeng Yan
  • + 3 authors

23 August 2021

Trichinellosis is a foodborne zoonotic disease caused by Trichinella spp., including Trichinella spiralis. In the present study, T. spiralis membrane-associated progesterone receptor component-2 (Ts-MAPRC2) gene was cloned and characterized usin...

  • Article
  • Open Access
73 Citations
8,387 Views
11 Pages

Assessing the Level and Determinants of COVID-19 Vaccine Confidence in Kenya

  • Stacey Orangi,
  • Jessie Pinchoff,
  • Daniel Mwanga,
  • Timothy Abuya,
  • Mainga Hamaluba,
  • George Warimwe,
  • Karen Austrian and
  • Edwine Barasa

23 August 2021

The government of Kenya has launched a phased rollout of COVID-19 vaccination. A major barrier is vaccine hesitancy; the refusal or delay of accepting vaccination. This study evaluated the level and determinants of vaccine hesitancy in Kenya. We cond...

  • Feature Paper
  • Article
  • Open Access
13 Citations
3,860 Views
9 Pages

The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R

  • Orna Mor,
  • Michal Mandelboim,
  • Shay Fleishon,
  • Efrat Bucris,
  • Dana Bar-Ilan,
  • Michal Linial,
  • Ital Nemet,
  • Limor Kliker,
  • Yaniv Lustig and
  • Neta S. Zuckerman
  • + 1 author

23 August 2021

Emerging SARS-CoV-2 variants may threaten global vaccination efforts and the awaited reduction in outbreak burden. In this study, we report a novel variant carrying the L452R mutation that emerged from a local B.1.362 lineage, B.1.362+L452R. The L452...

  • Review
  • Open Access
5 Citations
6,321 Views
31 Pages

Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges

  • John Hanna,
  • Padmavathi Tipparaju,
  • Tania Mulherkar,
  • Edward Lin,
  • Victoria Mischley,
  • Ratuja Kulkarni,
  • Aliyah Bolton,
  • Siddappa N. Byrareddy and
  • Pooja Jain

23 August 2021

The recent appearance of SARS-CoV-2 is responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic and has brought to light the importance of understanding this highly pathogenic agent to prevent future pandemics. This virus is from the...

  • Systematic Review
  • Open Access
32 Citations
6,303 Views
17 Pages

Nervous and Muscular Adverse Events after COVID-19 Vaccination: A Systematic Review and Meta-Analysis of Clinical Trials

  • Jiaxin Chen,
  • Yuangui Cai,
  • Yicong Chen,
  • Anthony P. Williams,
  • Yifang Gao and
  • Jinsheng Zeng

23 August 2021

Background: Nervous and muscular adverse events (NMAEs) have garnered considerable attention after the vaccination against coronavirus disease (COVID-19). However, the incidences of NMAEs remain unclear. We aimed to calculate the pooled event rate of...

  • Article
  • Open Access
5 Citations
5,006 Views
10 Pages

In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei

  • Durga Reddi,
  • Lydia Durant,
  • David Bernardo,
  • Alistair Noble,
  • Nicholas R. English,
  • Philip Hendy,
  • Graeme C. Clark,
  • Joann L. Prior,
  • Ethel Diane Williamson and
  • Stella C. Knight

22 August 2021

Murine dendritic cells, when pulsed with heat-killed Burkholderia pseudomallei and used to immunise naïve mice, have previously been shown to induce protective immunity in vivo. We have now demonstrated the in vitro priming of naïve human T cells aga...

  • Review
  • Open Access
22 Citations
5,984 Views
26 Pages

Alzheimer’s-Like Pathology at the Crossroads of HIV-Associated Neurological Disorders

  • Divya T. Chemparthy,
  • Muthukumar Kannan,
  • Lila Gordon,
  • Shilpa Buch and
  • Susmita Sil

21 August 2021

Despite the widespread success of combined antiretroviral therapy (cART) in suppressing viremia, the prevalence of human immunodeficiency virus (HIV)-associated neurological disorders (HAND) and associated comorbidities such as Alzheimer’s disease (A...

  • Article
  • Open Access
14 Citations
3,608 Views
7 Pages

21 August 2021

Mass vaccination campaigns are important to control the COVID-19 pandemic, however, adverse events (AEs) contribute to vaccine hesitancy. To investigate and compare early AEs between the BNT162b2 mRNA and AZD1222 adenovirus-vectored vaccines, recipie...

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Vaccines - ISSN 2076-393X