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Project Report

Changing Attitudes toward the COVID-19 Vaccine among North Carolina Participants in the COVID-19 Community Research Partnership

1
Department of Internal Medicine, Section on Infectious Diseases, Wake Forest School of Medicine, Winston-Salem, NC 27517, USA
2
Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27517, USA
3
Biostatistics Center, George Washington University Milken School of Public Health, Washington, DC 20052, USA
4
Jerry M. Wallace School of Osteopathic Medicine, Campbell University, Lillington, NC 27546, USA
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New Hanover Regional Medical Center, Wilmington, NC 28401, USA
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Wake Med Health and Hospitals, Raleigh, NC 27610, USA
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Atrium Health, Charlotte, NC 28204, USA
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Vidant Health, Greenville, NC 27834, USA
*
Author to whom correspondence should be addressed.
Contributed equally.
Academic Editors: Barbara Rath and Anthony R. Mawson
Vaccines 2021, 9(8), 916; https://doi.org/10.3390/vaccines9080916
Received: 14 May 2021 / Revised: 22 July 2021 / Accepted: 8 August 2021 / Published: 17 August 2021
(This article belongs to the Special Issue Vaccines: Uptake and Equity in Times of the COVID-19 Pandemic)
Coronavirus Disease-2019 (COVID-19) vaccine acceptance is variable. We surveyed participants in the COVID-19 Community Research Partnership from 17 December 2020 to 13 January 2021 to assess vaccine receptiveness. Vaccine uptake was then monitored until 15 May 2021; 20,232 participants responded to the receptiveness survey with vaccination status accessed in 18,874 participants via daily follow-up surveys (participants not completing daily surveys ≥30 days to 15 May 2021, were excluded). In the initial survey, 4802 (23.8%) were vaccine hesitant. Hesitancy was most apparent in women (Adjusted RR 0.93, p < 0.001), Black Americans (Adjusted RR 1.39, 1.41, 1.31 to non-Hispanic Whites, Other, and Hispanic or Latino, respectively p < 0.001), healthcare workers (Adjusted RR 0.93, p < 0.001), suburbanites (ref. Urban Adjusted RR 0.85, 0.90 to urban and rural dwellers, respectively, p < 0.01), and those previously diagnosed with COVID-19 (RR 1.20, p < 0.01). Those <50 years were also less accepting of vaccination. Subsequent vaccine uptake was 99% in non-hesitant participants. For those who were unsure, preferred not to answer, or answered “no”, vaccination rates were 80% (Adjusted RR 0.86, p < 0.0001), 78% (Adjusted RR 0.83, p < 0.0001), and 52.7% (Adjusted RR 0.65, p < 0.0001), respectively. These findings suggest that initial intent did not correlate with vaccine uptake in our cohort. View Full-Text
Keywords: vaccine hesitancy; vaccine intent; COVID-19; survey; North Carolina; vaccination; vaccine uptake; demographic groups vaccine hesitancy; vaccine intent; COVID-19; survey; North Carolina; vaccination; vaccine uptake; demographic groups
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MDPI and ACS Style

Enwezor, C.H.; Peacock, J.E., Jr.; Seals, A.L.; Edelstein, S.L.; Hinkelman, A.N.; Wierzba, T.F.; Munawar, I.; Maguire, P.D.; Lagarde, W.H.; Runyon, M.S.; Gibbs, M.A.; Gallaher, T.R.; Sanders, J.W., III; Herrington, D.M. Changing Attitudes toward the COVID-19 Vaccine among North Carolina Participants in the COVID-19 Community Research Partnership. Vaccines 2021, 9, 916. https://doi.org/10.3390/vaccines9080916

AMA Style

Enwezor CH, Peacock JE Jr., Seals AL, Edelstein SL, Hinkelman AN, Wierzba TF, Munawar I, Maguire PD, Lagarde WH, Runyon MS, Gibbs MA, Gallaher TR, Sanders JW III, Herrington DM. Changing Attitudes toward the COVID-19 Vaccine among North Carolina Participants in the COVID-19 Community Research Partnership. Vaccines. 2021; 9(8):916. https://doi.org/10.3390/vaccines9080916

Chicago/Turabian Style

Enwezor, Chukwunyelu H., James E. Peacock Jr., Austin L. Seals, Sharon L. Edelstein, Amy N. Hinkelman, Thomas F. Wierzba, Iqra Munawar, Patrick D. Maguire, William H. Lagarde, Michael S. Runyon, Michael A. Gibbs, Thomas R. Gallaher, John W. Sanders III, and David M. Herrington 2021. "Changing Attitudes toward the COVID-19 Vaccine among North Carolina Participants in the COVID-19 Community Research Partnership" Vaccines 9, no. 8: 916. https://doi.org/10.3390/vaccines9080916

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