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Vaccines, Volume 9, Issue 7

July 2021 - 122 articles

Cover Story: The aim of the present study was to identify mRNA expression profiles and to assess the impact of gut microbiome composition for predicting viral load control after antiretroviral therapy interruption upon vaccination. Patients with a decrease in their viral load of >0.5 log10 copies/mL by 12 weeks after antiretroviral therapy interruption were considered to be responders. In total, 66 genes were differentially expressed between the responders and non-responders; they were involved in the host defense response to a virus. Regarding the gut microbiota, we found important differences at the genus level, and it was associated with the metabolic production of short-chain fatty acids. The evidence now consistently shows that short-chain fatty acid depletion occurs in HIV-infected individuals receiving antiretroviral treatment. View this paper
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Articles (122)

  • Review
  • Open Access
15 Citations
14,893 Views
16 Pages

The World Health Organization (WHO) has placed N. gonorrhoeae on the global priority list of antimicrobial resistant pathogens and is urgently seeking the development of new intervention strategies. N. gonorrhoeae causes 86.9 million cases globally p...

  • Article
  • Open Access
10 Citations
3,867 Views
10 Pages

Background: Racial/ethnic minorities generally have a lower knowledge of human papillomavirus (HPV) and the HPV vaccine than non-Hispanic Whites. They are also less likely to have a regular healthcare provider (HCP). Given the role of HCPs in dissemi...

  • Article
  • Open Access
21 Citations
5,935 Views
20 Pages

A Pseudomonas aeruginosa-Derived Particulate Vaccine Protects against P. aeruginosa Infection

  • Zennia Jean C. Gonzaga,
  • Christina Merakou,
  • Antonio DiGiandomenico,
  • Gregory P. Priebe and
  • Bernd H. A. Rehm

Despite numerous efforts to develop an effective vaccine against Pseudomonas aeruginosa, no vaccine has yet been approved for human use. This study investigates the utility of the P. aeruginosa inherently produced polyhydroxyalkanaote (PHA) inclusion...

  • Communication
  • Open Access
4 Citations
3,653 Views
12 Pages

Timely Birth Dose Vaccine to Prevent Vertical Transmission of Hepatitis B: A Single Center Experience on the Road to the WHO Elimination Goals in Italy

  • Michele Pinon,
  • Laura Giugliano,
  • Emanuele Nicastro,
  • Omar Kakaa,
  • Alessandra Coscia,
  • Caterina Carbonara,
  • Lorenzo D’Antiga and
  • Pier Luigi Calvo

Italy was one of the first industrialized countries to implement a program of routine vaccination against hepatitis B virus (HBV) infection. However, currently, no HBV vaccine is administered at birth if the screened mother is HBsAg negative, whilst...

  • Article
  • Open Access
4 Citations
3,598 Views
12 Pages

Mutation E48K in PB1 Polymerase Subunit Improves Stability of a Candidate Live Attenuated Influenza B Virus Vaccine

  • Jongsuk Mo,
  • Stivalis Cardenas-Garcia,
  • Jefferson J. S. Santos,
  • Lucas M. Ferreri,
  • C. Joaquín Cáceres,
  • Ginger Geiger,
  • Daniel R. Perez and
  • Daniela S. Rajao

Influenza B virus (IBV) is a major respiratory pathogen of humans, particularly in the elderly and children, and vaccines are the most effective way to control it. In previous work, incorporation of two mutations (E580G, S660A) along with the additio...

  • Article
  • Open Access
3 Citations
4,208 Views
11 Pages

Association of Transcriptomic Signatures of Inflammatory Response with Viral Control after Dendritic Cell-Based Therapeutic Vaccination in HIV-1 Infected Individuals

  • Csaba Fehér,
  • Roque Pastor-lbáñez,
  • Lorna Leal,
  • Montserrat Plana,
  • Mireia Arnedo,
  • Henk-Jan van den Ham,
  • Arno C. Andeweg,
  • Rob A. Gruters,
  • Francisco Díez-Fuertes and
  • José Alcamí
  • + 2 authors

Systems vaccinology has seldomly been used in therapeutic HIV-1 vaccine research. Our aim was to identify early gene ‘signatures’ that predicted virus load control after analytical therapy interruption (ATI) in participants of a dendritic cell-based...

  • Article
  • Open Access
21 Citations
4,882 Views
11 Pages

Attitudes toward the SARS-CoV-2 Vaccine: Results from the Saudi Residents’ Intention to Get Vaccinated against COVID-19 (SRIGVAC) Study

  • Sami H. Alzahrani,
  • Mukhtiar Baig,
  • Mohammed W. Alrabia,
  • Mohammed R. Algethami,
  • Meshari M. Alhamdan,
  • Nabil A. Alhakamy,
  • Hani Z. Asfour and
  • Tauseef Ahmad

Vaccine uptake could influence vaccination efforts to control the widespread COVID-19 pandemic; however, little is known about vaccine acceptance in Saudi Arabia. The present study aimed to assess the Saudi public’s intent to get vaccinated against C...

  • Article
  • Open Access
3 Citations
5,094 Views
13 Pages

Incidence of Vaccine-Preventable Childhood Diseases in the European Union and in the European Free Trade Association Countries

  • Estera Jachowicz,
  • Magdalena Gębicka,
  • Daria Plakhtyr,
  • Myroslav Shynkarenko,
  • Juri Urbanowicz,
  • Maciej Mach,
  • Jacek Czepiel,
  • Jakub Marchewka and
  • Jadwiga Wójkowska-Mach

Introduction: Despite the widespread availability of vaccines, the incidence of vaccine-preventable childhood diseases (VPCD) started to grow in recent years. The aim of the study was to compare the annual incidence of selected VPCDs in the EU (Europ...

  • Article
  • Open Access
8 Citations
5,196 Views
21 Pages

Coronavirus disease (COVID-19) pandemic caused by the coronavirus SARS-CoV-2 represents an enormous challenge to global public health, with thousands of infections and deaths in over 200 countries worldwide. The purpose of this study was to identify...

  • Article
  • Open Access
13 Citations
3,675 Views
11 Pages

Establishment of Recombinant Eimeria acervulina Expressing Multi-Copies M2e Derived from Avian Influenza Virus H9N2

  • Sixin Zhang,
  • Xinming Tang,
  • Si Wang,
  • Fangyun Shi,
  • Chunhui Duan,
  • Feifei Bi,
  • Jingxia Suo,
  • Dandan Hu,
  • Jie Liu and
  • Chaoyue Wang
  • + 2 authors

The potential of Eimeria parasites as live vaccine vectors has been reported with successful genetic manipulation on several species like E. tenella, E. mitis and E. necatrix. Among seven Eimeria species infecting chickens, E. acervulina is a highly...

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Vaccines - ISSN 2076-393X