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Vaccines, Volume 7, Issue 1

March 2019 - 33 articles

Cover Story: African swine fever virus (ASFV) causes high morbidity and mortality in swine and its recent spread into Western Europe and China highlights the urgent need to find a vaccine. Efficacy of vaccination with a DNA-protein cocktail of immunogenic ASFV antigens against virulent ASFV challenge with the Armenia 2007 strain in pigs was evaluated. Vaccinated animals had earlier onset of disease and death, and pathology tended to be more severe in vaccinees. A: Hemorrhagic lymphadenopathy, gastrohepatic lymph nodes (GHLN) with edema of the mesentery, common bile duct and gall bladder. B, C: Marked hemorrhage, edema and severe necrosis of lymphocytes (GHLN). These results indicate that a better understanding of detrimental immunopathological responses leading to ASFV pathology is important for the development of a safe and efficacious ASFV vaccine. View this paper
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Articles (33)

  • Article
  • Open Access
28 Citations
7,100 Views
12 Pages

Safety and Immunogenicity of the Heterosubtypic Influenza A Vaccine MVA-NP+M1 Manufactured on the AGE1.CR.pIX Avian Cell Line

  • Pedro M. Folegatti,
  • Duncan Bellamy,
  • Amy Flaxman,
  • Catherine Mair,
  • Chris Ellis,
  • Raquel L. Ramon,
  • Fernando Ramos Lopez,
  • Celia Mitton,
  • Megan Baker and
  • Ian Poulton
  • + 7 authors

Seasonal influenza infections have a significant global impact leading to increased health and economic burden. The efficacy of currently available seasonal influenza vaccines targeting polymorphic surface antigens has historically been suboptimal. C...

  • Reply
  • Open Access
1 Citations
4,104 Views
1 Page

Kenyon (2019) is correct to suggest that there is limited evidence of longer term effectiveness [...]

  • Comment
  • Open Access
4 Citations
5,086 Views
2 Pages
  • Article
  • Open Access
11 Citations
4,483 Views
15 Pages

Neuraminidase (NA) content is not standardized in current seasonal influenza vaccines; neither anti-NA antibodies (anti-NA Abs) are measured nor is it well-defined as a correlate of humoral protection. In this work, the presence of NA1 antibodies aga...

  • Article
  • Open Access
21 Citations
6,961 Views
15 Pages

The spontaneous reporting of suspected adverse events following immunization (AEFI) by healthcare professionals (HCPs) is vital in monitoring post-licensure vaccine safety. The main objective of this study was to assess the knowledge and perceptions...

  • Article
  • Open Access
6 Citations
3,924 Views
13 Pages

We previously reported that recombinant measles virus expressing the respiratory syncytial virus (RSV) fusion protein (F), MVAIK/RSV/F, induced neutralizing antibodies against RSV, and those expressing RSV-NP (MVAIK/RSV/NP) and M2-1 (MVAIK/RSV/M2-1)...

  • Review
  • Open Access
14 Citations
4,044 Views
14 Pages

Will Attention by Vaccine Developers to the Host’s Nuclear Hormone Levels and Immunocompetence Improve Vaccine Success?

  • Robert E. Sealy,
  • Bart G. Jones,
  • Sherri L. Surman,
  • Rhiannon R. Penkert,
  • Stephane Pelletier,
  • Geoff Neale and
  • Julia L. Hurwitz

27 February 2019

Despite extraordinary advances in fields of immunology and infectious diseases, vaccine development remains a challenge. The development of a respiratory syncytial virus vaccine, for example, has spanned more than 50 years of research with studies of...

  • Article
  • Open Access
18 Citations
5,234 Views
11 Pages

24 February 2019

There is little research on state-level differences in child health outcomes in India. The aim of this study was to identify state-level characteristics that relate to childhood immunizations. Most state-level characteristics came from the 2011 India...

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Vaccines - ISSN 2076-393X