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Vaccines, Volume 7, Issue 1

March 2019 - 33 articles

Cover Story: African swine fever virus (ASFV) causes high morbidity and mortality in swine and its recent spread into Western Europe and China highlights the urgent need to find a vaccine. Efficacy of vaccination with a DNA-protein cocktail of immunogenic ASFV antigens against virulent ASFV challenge with the Armenia 2007 strain in pigs was evaluated. Vaccinated animals had earlier onset of disease and death, and pathology tended to be more severe in vaccinees. A: Hemorrhagic lymphadenopathy, gastrohepatic lymph nodes (GHLN) with edema of the mesentery, common bile duct and gall bladder. B, C: Marked hemorrhage, edema and severe necrosis of lymphocytes (GHLN). These results indicate that a better understanding of detrimental immunopathological responses leading to ASFV pathology is important for the development of a safe and efficacious ASFV vaccine. View this paper
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Articles (33)

  • Article
  • Open Access
31 Citations
8,154 Views
17 Pages
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Epitope-Specific Serological Assays for RSV: Conformation Matters

  • Emily Phung,
  • Lauren A. Chang,
  • Kaitlyn M. Morabito,
  • Masaru Kanekiyo,
  • Man Chen,
  • Deepika Nair,
  • Azad Kumar,
  • Grace L. Chen,
  • Julie E. Ledgerwood and
  • Barney S. Graham
  • + 1 author
Vaccines2019, 7(1), 23;https://doi.org/10.3390/vaccines7010023

23 February 2019

Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in children and older adults. An effective vaccine must elicit neutralizing antibodies targeting the RSV fusion (F) protein, which exists in two major conformations, pre-fus...

Full Article
  • Review
  • Open Access
10 Citations
4,600 Views
11 Pages
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Role of Type I Interferons on Filovirus Pathogenesis

  • Beatriz Escudero-Pérez and
  • César Muñoz-Fontela
Vaccines2019, 7(1), 22;https://doi.org/10.3390/vaccines7010022

20 February 2019

Filoviruses, such as Ebola and Marburg virus, encode viral proteins with the ability to counteract the type I interferon (IFN-I) response. These IFN-I antagonist proteins are crucial to ensure virus replication, prevent an antiviral state in infected...

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  • Article
  • Open Access
13 Citations
6,499 Views
20 Pages
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Comparison of Immune Responses to Different Versions of VLP Associated Stabilized RSV Pre-Fusion F Protein

  • Lori M. Cullen,
  • Madelyn R. Schmidt,
  • Gretel M. Torres,
  • Adam A. Capoferri and
  • Trudy G. Morrison
Vaccines2019, 7(1), 21;https://doi.org/10.3390/vaccines7010021

15 February 2019

Efforts to develop a vaccine for respiratory syncytial virus (RSV) have primarily focused on the RSV fusion protein. The pre-fusion conformation of this protein induces the most potent neutralizing antibodies and is the focus of recent efforts in vac...

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  • Article
  • Open Access
7 Citations
4,349 Views
21 Pages
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Differential Response Following Infection of Mouse CNS with Virulent and Attenuated Vaccinia Virus Strains

  • Tomer Israely,
  • Nir Paran,
  • Noam Erez,
  • Lilach Cherry,
  • Hadas Tamir,
  • Hagit Achdout,
  • Boaz Politi,
  • Ofir Israeli,
  • Galia Zaide and
  • Inbar Cohen-Gihon
  • + 3 authors
Vaccines2019, 7(1), 19;https://doi.org/10.3390/vaccines7010019

12 February 2019

Viral infections of the central nervous system (CNS) lead to a broad range of pathologies. CNS infections with Orthopox viruses have been mainly documented as an adverse reaction to smallpox vaccination with vaccinia virus. To date, there is insuffic...

Full Article
  • Review
  • Open Access
6 Citations
5,071 Views
13 Pages
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Feasibility Analysis of Interleukin-13 as a Target for a Therapeutic Vaccine

  • John Foerster and
  • Aleksandra Molęda
Vaccines2019, 7(1), 20;https://doi.org/10.3390/vaccines7010020

12 February 2019

Background: The development of therapeutic vaccines requires thorough knowledge of potential hazards associated with long-term inactivation of self-proteins. Among potential targets, interleukin 13 (IL-13) merits consideration, as monoclonal antibodi...

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  • Review
  • Open Access
23 Citations
6,260 Views
13 Pages
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Complementary Role of CD4+ T Cells in Response to Pneumococcal Polysaccharide Vaccines in Humans

  • Vibha Jha and
  • Edward N. Janoff
Vaccines2019, 7(1), 18;https://doi.org/10.3390/vaccines7010018

11 February 2019

Bacterial pathogens expressing capsular polysaccharides are common causes of mucosal infections (pneumonia, intestinal), as well as often fatal, invasive infections (meningitis, bloodstream infections) in children and adults worldwide. These chemical...

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  • Article
  • Open Access
7 Citations
4,962 Views
14 Pages
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Immunogenicity and Immune Memory after a Pneumococcal Polysaccharide Vaccine Booster in a High-Risk Population Primed with 10-Valent or 13-Valent Pneumococcal Conjugate Vaccine: A Randomized Controlled Trial in Papua New Guinean Children

  • Anita H. J. van den Biggelaar,
  • William S. Pomat,
  • Geraldine Masiria,
  • Sandra Wana,
  • Birunu Nivio,
  • Jacinta Francis,
  • Rebecca Ford,
  • Megan Passey,
  • Lea-Ann Kirkham and
  • Peter Jacoby
  • + 3 authors
Vaccines2019, 7(1), 17;https://doi.org/10.3390/vaccines7010017

4 February 2019

We investigated the immunogenicity, seroprotection rates and persistence of immune memory in young children at high risk of pneumococcal disease in Papua New Guinea (PNG). Children were primed with 10-valent (PCV10) or 13-valent pneumococcal conjugat...

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  • Article
  • Open Access
8 Citations
12,374 Views
15 Pages
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Development of Luciferase Immunoprecipitation Systems (LIPS) Assay to Detect IgG Antibodies against Human Respiratory Syncytial Virus G-Glycoprotein

  • Roberta Lynne Crim,
  • Sangeeta Kumari,
  • Priyanka Jayanti,
  • Susette Audet,
  • Ashwin Kulkarni and
  • Judy Beeler
Vaccines2019, 7(1), 16;https://doi.org/10.3390/vaccines7010016

1 February 2019

Respiratory syncytial virus (RSV) causes severe lower respiratory tract disease in infants and the elderly. Although there is no licensed vaccine, RSV-F and -G glycoproteins are targets for vaccine development and therapeutics. We developed an assay...

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  • Article
  • Open Access
12 Citations
4,901 Views
14 Pages
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PCV7- and PCV10-Vaccinated Otitis-Prone Children in New Zealand Have Similar Pneumococcal and Haemophilus influenzae Densities in Their Nasopharynx and Middle Ear

  • Camilla de Gier,
  • Caitlyn M. Granland,
  • Janessa L. Pickering,
  • Tony Walls,
  • Mejbah Bhuiyan,
  • Nikki Mills,
  • Peter C. Richmond,
  • Emma J. Best,
  • Ruth B. Thornton and
  • Lea-Ann S. Kirkham
Vaccines2019, 7(1), 14;https://doi.org/10.3390/vaccines7010014

31 January 2019

Otitis media (OM) is a major reason for antibiotic consumption and surgery in children. Nasopharyngeal carriage of otopathogens, Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi), is a prerequisite for development of OM, and incr...

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