Antioxidants, Volume 7, Issue 1 (January 2018) – 21 articles
Cover Story (view full-size image): We have previously shown that the DHHC6 enzyme binds to selenoprotein K (SELENOK) in the endoplasmic reticulum membrane to catalyze the post-translational palmitoylation of several proteins. Herein, we reveal that the selenocysteine residue in SELENOK (Sec92) functions to stabilize the palmitoylated DHHC6 intermediate by protecting the thioester bond between the palmitate and cysteine residue in DHHC6 from hydrolysis. This allows transfer of the palmitate from DHHC6 to cysteine residues on target proteins, thereby increasing the catalytic efficiency of this reaction. View the paper here.
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