Next Article in Journal
Cytokine Response to Exercise and Its Modulation
Next Article in Special Issue
Morphological Pathways of Mitochondrial Division
Previous Article in Journal / Special Issue
Regulation of Mitochondrial Dynamics by Proteolytic Processing and Protein Turnover
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Antioxidants 2018, 7(1), 16; https://doi.org/10.3390/antiox7010016

Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change

1
College of Medicine, University of Kentucky, 800 Rose St., Lexington, KY 40506, USA
2
Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA
*
Author to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 2 January 2018 / Accepted: 14 January 2018 / Published: 17 January 2018
(This article belongs to the Special Issue Mitochondrial Shape Change in Physio-Pathology)
Full-Text   |   PDF [816 KB, uploaded 17 January 2018]   |  

Abstract

The mitochondrion is an important organelle and provides energy for a plethora of intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and alteration in metabolism has been identified in multiple disease states—cancer being one. Otto Warburg demonstrated that cancer cells, in the presence of oxygen, undergo glycolysis by reprogramming their metabolism—termed “aerobic glycolysis”. Alterations in metabolism enable cancer cells to gain a growth advantage by obtaining precursors for macromolecule biosynthesis, such as nucleic acids and lipids. To date, several molecules, termed “oncometabolites”, have been identified to be elevated in cancer cells and arise from mutations in nuclear encoded mitochondrial enzymes. Furthermore, there is evidence that oncometabolites can affect mitochondrial dynamics. It is believed that oncometabolites can assist in reprogramming enzymatic pathways and providing cancer cells with selective advantages. In this review, we will touch upon the effects of normal and aberrant mitochondrial metabolism in normal and cancer cells, the advantages of metabolic reprogramming, effects of oncometabolites on metabolism and mitochondrial dynamics and therapies aimed at targeting oncometabolites and metabolic aberrations. View Full-Text
Keywords: mitochondria; oncometabolites; cancer; metabolic re-programming; aerobic glycolysis; mitochondrial dynamics mitochondria; oncometabolites; cancer; metabolic re-programming; aerobic glycolysis; mitochondrial dynamics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Zhou, Z.; Ibekwe, E.; Chornenkyy, Y. Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change. Antioxidants 2018, 7, 16.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top