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Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology

1
Cardiovascular Research Center, Division of Cardiothoracic Surgery, Department of Surgery, Rhode Island Hospital, Brown University Alpert Medical School, 1 Hoppin St, Coro West 5.231, Providence, RI 02903, USA
2
Providence VA Medical Center, Providence, RI 02908, USA
*
Author to whom correspondence should be addressed.
Antioxidants 2018, 7(1), 14; https://doi.org/10.3390/antiox7010014
Received: 10 November 2017 / Revised: 14 January 2018 / Accepted: 15 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue ROS Derived from NADPH Oxidase (NOX) in Angiogenesis)
There exist two opposing perspectives regarding reactive oxygen species (ROS) and their roles in angiogenesis and cardiovascular system, one that favors harmful and causal effects of ROS, while the other supports beneficial effects. Recent studies have shown that interaction between ROS in different sub-cellular compartments plays a crucial role in determining the outcomes (beneficial vs. deleterious) of ROS exposures on the vascular system. Oxidant radicals in one cellular organelle can affect the ROS content and function in other sub-cellular compartments in endothelial cells (ECs). In this review, we will focus on a critical fact that the effects or the final phenotypic outcome of ROS exposure to EC are tissue- or organ-specific, and depend on the spatial (subcellular localization) and temporal (duration of ROS exposure) modulation of ROS levels. View Full-Text
Keywords: ROS; cardiovascular disease; Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase; mitochondrial ROS; angiogenesis; coronary endothelium ROS; cardiovascular disease; Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase; mitochondrial ROS; angiogenesis; coronary endothelium
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MDPI and ACS Style

Aldosari, S.; Awad, M.; Harrington, E.O.; Sellke, F.W.; Abid, M.R. Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology. Antioxidants 2018, 7, 14. https://doi.org/10.3390/antiox7010014

AMA Style

Aldosari S, Awad M, Harrington EO, Sellke FW, Abid MR. Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology. Antioxidants. 2018; 7(1):14. https://doi.org/10.3390/antiox7010014

Chicago/Turabian Style

Aldosari, Sarah, Maan Awad, Elizabeth O. Harrington, Frank W. Sellke, and M. R. Abid 2018. "Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology" Antioxidants 7, no. 1: 14. https://doi.org/10.3390/antiox7010014

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