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Brain Sciences, Volume 9, Issue 1

January 2019 - 17 articles

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Cover Story: Like humans, some rodents will drink to excess, and a tendency to binge drink is in part inherited. The cover image shows inbred High Drinking in the Dark mice. These mice have been bred for their willingness to drink alcohol to the point of intoxication, and offer insight into the genetic contributors to risk. The paper explores their motivation to drink in binge-like fashion and reports their apparent failure to stop drinking once intoxication has occurred. The animals offer a partial model for one of the most troubling features of alcohol use disorders. View this paper

Articles (17)

  • Case Report
  • Open Access
10 Citations
5,616 Views
8 Pages

21 January 2019

Objective: To report a patient in whom an acute ischemic stroke precipitated chronic blood-brain barrier (BBB) disruption and expansion of vascular white matter hyperintensities (WMH) into regions of normal appearing white matter (NAWM) during the fo...

  • Review
  • Open Access
14 Citations
8,581 Views
14 Pages

CRISPR to the Rescue: Advances in Gene Editing for the FMR1 Gene

  • Carolyn M. Yrigollen and
  • Beverly L. Davidson

21 January 2019

Gene-editing using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is promising as a potential therapeutic strategy for many genetic disorders. CRISPR-based therapies are already being assessed in clinical trials, and evaluation of...

  • Article
  • Open Access
11 Citations
5,840 Views
14 Pages

Comparative Behavioral Phenotypes of Fmr1 KO, Fxr2 Het, and Fmr1 KO/Fxr2 Het Mice

  • Rachel Michelle Saré,
  • Christopher Figueroa,
  • Abigail Lemons,
  • Inna Loutaev and
  • Carolyn Beebe Smith

16 January 2019

Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene leading to loss of the protein product fragile X mental retardation protein (FMRP). FXS is the most common monogenic cause of intellectual disability. There are two known mammalian para...

  • Review
  • Open Access
26 Citations
7,760 Views
21 Pages

16 January 2019

The chief psychoactive constituent of many bioactive phytocannabinoids (Δ9-tetrahydrocannabinol, Δ9-THC) found in hemp, cannabis or marijuana plants are scientifically denoted by the Latin term, Cannabis sativa, acts on cell surface recep...

  • Review
  • Open Access
39 Citations
7,527 Views
29 Pages

Executive Function in Fragile X Syndrome: A Systematic Review

  • Lauren M. Schmitt,
  • Rebecca C. Shaffer,
  • David Hessl and
  • Craig Erickson

16 January 2019

Executive function (EF) supports goal-directed behavior and includes key aspects such as working memory, inhibitory control, cognitive flexibility, attention, processing speed, and planning. Fragile X syndrome (FXS) is the leading inherited monogenic...

  • Article
  • Open Access
14 Citations
10,234 Views
11 Pages

Self-Esteem Group: Useful Intervention for Inpatients with Anorexia Nervosa?

  • James Adamson,
  • Cansu Ozenc,
  • Claire Baillie and
  • Kate Tchanturia

13 January 2019

Low self-esteem is a common feature in Anorexia Nervosa (AN) and has been hypothesised to act as a predisposing, precipitating, and perpetuating factor. The aim of this study was to assess the effectiveness of a Cognitive Behavioural Therapy (CBT)-ba...

  • Review
  • Open Access
87 Citations
13,181 Views
14 Pages

Closing the Gender Gap in Fragile X Syndrome: Review of Females with Fragile X Syndrome and Preliminary Research Findings

  • Kristi L. Bartholomay,
  • Cindy H. Lee,
  • Jennifer L. Bruno,
  • Amy A. Lightbody and
  • Allan L. Reiss

12 January 2019

Fragile X syndrome (FXS) is a genetic condition known to increase the risk of cognitive impairment and socio-emotional challenges in affected males and females. To date, the vast majority of research on FXS has predominantly targeted males, who usual...

  • Article
  • Open Access
12 Citations
5,732 Views
5 Pages

Sleep Disorders Following Mild and Moderate Traumatic Brain Injury

  • Laith Thamer Al-Ameri,
  • Talib Saddam Mohsin and
  • Ali Tarik Abdul Wahid

11 January 2019

(1) Background: Sleeping disorders are frequently reported following traumatic brain injury (TBI). Different forms of sleeping disorders have been reported, such as sleepiness, insomnia, changes in sleeping latency, and others. (2) Methods: A case-co...

  • Article
  • Open Access
27 Citations
5,909 Views
9 Pages

MyomiRNAs Dysregulation in ALS Rehabilitation

  • Valentina Pegoraro,
  • Antonio Merico and
  • Corrado Angelini

Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder caused by degeneration of upper and lower motor neurons. The disease process leads, because of lower motor neuron involvement, to progressive muscle atrophy, weakn...

  • Reply
  • Open Access
21 Citations
10,295 Views
5 Pages

Dyslexia: Still Not a Neurodevelopmental Disorder

  • Athanassios Protopapas and
  • Rauno Parrila

We recently pointed out that there is no evidence to support the commonly held view that there is something wrong with the brains of children who have great difficulty learning to read. In response, it was argued that dyslexia should be considered to...

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