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Brain Sciences, Volume 9, Issue 1

January 2019 - 17 articles

Cover Story: Like humans, some rodents will drink to excess, and a tendency to binge drink is in part inherited. The cover image shows inbred High Drinking in the Dark mice. These mice have been bred for their willingness to drink alcohol to the point of intoxication, and offer insight into the genetic contributors to risk. The paper explores their motivation to drink in binge-like fashion and reports their apparent failure to stop drinking once intoxication has occurred. The animals offer a partial model for one of the most troubling features of alcohol use disorders. View this paper
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Articles (17)

  • Article
  • Open Access
31 Citations
7,629 Views
18 Pages

The Motivational Power of the Happy Face

  • Jana Nikitin and
  • Alexandra M. Freund

People who are cheerful have better social relationships. This might be the case because happy faces communicate an invitation to interact. Thus, happy faces might have a strong motivational effect on others. We tested this hypothesis in a set of fou...

  • Review
  • Open Access
5 Citations
6,009 Views
8 Pages

The nucleus accumbens (NA) and the cingulate gyrus (CG) are two vital limbic brain structures. They have attracted attention as deep brain stimulation (DBS) targets in the treatment of common refractory psychiatric illness. The primary purpose of thi...

  • Review
  • Open Access
27 Citations
7,083 Views
12 Pages

Early Identification of Fragile X Syndrome through Expanded Newborn Screening

  • Katherine C. Okoniewski,
  • Anne C. Wheeler,
  • Stacey Lee,
  • Beth Boyea,
  • Melissa Raspa,
  • Jennifer L. Taylor and
  • Donald B. Bailey

Over the past 20 years, research on fragile X syndrome (FXS) has provided foundational understanding of the complex experiences of affected individuals and their families. Despite this intensive focus, there has been little progress on earlier identi...

  • Article
  • Open Access
6 Citations
4,735 Views
14 Pages

Two multimodal classification models aimed at enhancing object classification through the integration of semantically congruent unimodal stimuli are introduced. The feature-integrating model, inspired by multisensory integration in the subcortical su...

  • Article
  • Open Access
22 Citations
6,182 Views
15 Pages

Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice

  • John C. Crabbe,
  • Pamela Metten,
  • Antonia M. Savarese,
  • Angela R. Ozburn,
  • Jason P. Schlumbohm,
  • Stephanie E. Spence and
  • Wyatt R. Hack

Two independent lines of High Drinking in the Dark (HDID-1, HDID-2) mice have been bred to reach high blood alcohol levels after a short period of binge-like ethanol drinking. Male mice of both lines were shown to have reduced sensitivity to develop...

  • Article
  • Open Access
6 Citations
5,099 Views
13 Pages

Differential Expression of Genes Related to Innate Immune Responses in Ex Vivo Spinal Cord and Cerebellar Slice Cultures Infected with West Nile Virus

  • Parminder J. S. Vig,
  • Deyin Lu,
  • Amber M. Paul,
  • Ram Kuwar,
  • Maria Lopez,
  • Dobrivoje S. Stokic,
  • A. Arturo Leis,
  • Michael R. Garrett and
  • Fengwei Bai

24 December 2018

West Nile virus (WNV) infection results in a spectrum of neurological symptoms, ranging from a benign fever to severe WNV neuroinvasive disease with high mortality. Many who recover from WNV neuroinvasive infection present with long-term deficits, in...

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Brain Sci. - ISSN 2076-3425