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Neurofilaments: The C-Reactive Protein of Neurology

Department of Neurology, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense C, Denmark
Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 21, st, 5000 Odense C, Denmark
BRIDGE—Brain Research—Inter Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 3. sal, 5000 Odense C, Denmark
Department of Clinical Research, Neurology Research Unit, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(1), 56;
Received: 21 December 2019 / Revised: 14 January 2020 / Accepted: 16 January 2020 / Published: 18 January 2020
(This article belongs to the Section Molecular and Cellular Neuroscience)
Neurofilaments (NFs) are quickly becoming the biomarkers of choice in the field of neurology, suggesting their use as an unspecific screening marker, much like the use of elevated plasma C-reactive protein (CRP) in other fields. With sensitive techniques being readily available, evidence is growing regarding the diagnostic and prognostic value of NFs in many neurological disorders. Here, we review the latest literature on the structure and function of NFs and report the strengths and pitfalls of NFs as markers of neurodegeneration in the context of neurological diseases of the central and peripheral nervous systems. View Full-Text
Keywords: neuroaxonal damage; biomarker; blood; serum; plasma neuroaxonal damage; biomarker; blood; serum; plasma
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Lambertsen, K.L.; Soares, C.B.; Gaist, D.; Nielsen, H.H. Neurofilaments: The C-Reactive Protein of Neurology. Brain Sci. 2020, 10, 56.

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