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Microorganisms, Volume 7, Issue 9 (September 2019)
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Cover Story (view full-size image) Over twenty years of research efforts have contributed to defining the structure and physiology of [...] Read more. Over twenty years of research efforts have contributed to defining the structure and physiology of the intestine of the genetic model organism Drosophila melanogaster and to establishing its similarity with the human gastrointestinal tract. The development of state-of-the-art genetic tools to study the Drosophila intestine enhanced the number of discoveries that affirmed the conservation of pathways that govern the (patho)physiology of the intestine Drosophila and in humans. Thus, Drosophila melanogaster has become a versatile model organism for human enteric studies. Here, Capo et al, summarize our current knowledge of the structure and functions of the Drosophila melanogaster intestine, asserting its validity as an emerging model system to study gut physiology, regeneration, immune defenses, and host–microbiota interactions. View this paper.