Insights Into The Molecular Pathogenesis of Ocular Infections

Background: Ocular infections can have devastating consequences on vision. Infections of the conjunctiva and cornea are among the most common reasons for primary care physician visits. While conjunctivitis is not a threat to vision, keratitis is considered a medical emergency and can cause vision loss and blindness. Infections of the posterior segment are among the most devastating and can result in rapid blindness and loss of the eye despite treatment. With the number of ocular surgical procedures (e.g., cataract surgery and intravitreal injections) continuing to increase, the incidence of intraocular infections is also increasing. Complicating treatment is the increasing prevalence of multi-drug-resistant ocular pathogens.

Goal: Basic and translational research on the molecular mechanisms of the pathogenesis of and host inflammatory responses to ocular infections is required in order to develop more effective treatment strategies to prevent the devastating consequences of these infections.

Scope: This Special Issue will highlight ocular infections of all types, with an emphasis on the molecular mechanisms of pathogenesis, the host inflammatory response, and novel therapeutics. Authors are invited to submit original basic and translational research articles or reviews on infections affecting the cornea and conjunctiva, and infections of the posterior segment, including endophthalmitis, uveitis, chorioretinitis, and retinitis. Articles on the impact of the microbiota on ocular infections are also encouraged.

Dr. Michelle C. Callegan
Dr. Phillip S. Coburn
Guest Editors

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