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Pathogens, Volume 14, Issue 3

March 2025 - 95 articles

Cover Story: HIV infection cannot be cured due to latently infected cells carrying intact but inactive HIV DNA, making them indistinguishable from uninfected cells. Several strategies have been developed to cure HIV infection, including the reactivation of HIV in latently infected cells, resulting in recognition and death—the “shock and kill” approach. Various latency-reversing agents (LRAs) have been tested in clinical trials. Some were successful in reactivating HIV in vivo and induced detectable changes in the reservoir. Though the technique is not yet curative, these trials prove that latently infected cells can be targeted. In combination with the latest immunomodulatory drugs that aid in killing cells that replicate HIV, new strategies and novel LRAs may be developed in the near future to cure HIV infection. View this paper
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Articles (95)

  • Article
  • Open Access
1,085 Views
9 Pages

Improving HCV Screening in Addiction Care Centers with Plasma Separation Cards

  • Fernando Velásquez Orozco,
  • David Tabernero,
  • María Gabriela Barbaglia,
  • Lara Treviño,
  • Begoña Trujillo,
  • Andrés Marco,
  • Miguel Ángel Carrillo,
  • Gerard Ruiz Salinas,
  • Francesc Xavier Majo Roca and
  • Joan Colom Farran
  • + 4 authors

Globally, 50 million people are infected with hepatitis C virus (HCV), many of whom are people who inject drugs. These individuals face healthcare barriers, necessitating innovative diagnostic tools. This study evaluated the impact of cobas plasma se...

  • Article
  • Open Access
1 Citations
2,666 Views
15 Pages

Rapid Detection of Panton–Valentine Leukocidin Production in Clinical Isolates of Staphylococcus aureus from Saxony and Brandenburg and Their Molecular Characterisation

  • Elke Müller,
  • Stefan Monecke,
  • Marc Armengol Porta,
  • Marco Vinicio Narvaez Encalada,
  • Annett Reissig,
  • Lukas Rüttiger,
  • Percy Schröttner,
  • Ilona Schwede,
  • Hans-Herman Söffing and
  • Alexander Thürmer
  • + 1 author

Panton–Valentine leukocidin (PVL) is a staphylococcal toxin associated with chronic/recurrent skin and soft tissue infections (SSTIs) and necrotizing pneumonia. Its detection in clinical isolates of Staphylococcus aureus warrants aggressive the...

  • Brief Report
  • Open Access
1 Citations
2,272 Views
7 Pages

Acute Influenza Virus-Associated Encephalitis and Other Neurological Complications in Severe Hospitalized Laboratory-Confirmed Influenza Cases—Catalonia 2010–2020

  • Pilar Ciruela,
  • Nuria Soldevila,
  • Nuria Torner,
  • Luca Basile,
  • Maria del Mar Mosquera,
  • M. Angeles Marcos,
  • Anna Martínez,
  • Mireia Jané,
  • Cristina Rius and
  • Angela Domínguez
  • + 1 author

28 February 2025

Neurological complications associated with influenza (NCIs) are rare events in adults. Influenza-associated encephalopathy is one of the most severe and frequently reported NCIs. The aim of this study is to describe the frequency and characteristics...

  • Review
  • Open Access
2 Citations
3,244 Views
31 Pages

28 February 2025

BK polyomavirus (BKPyV) is a pathogen responsible for infectious complications in hematopoietic stem cell transplant (HSCT) recipients. This review aims to give an insight into recent data about the structure and genomic organization, epidemiology, c...

  • Article
  • Open Access
1 Citations
1,277 Views
22 Pages

Extensive T-Cell Profiling Following SARS-CoV-2 mRNA Vaccination in Multiple Sclerosis Patients Treated with DMTs

  • Hannah Solchenberger,
  • Marcus Odendahl,
  • Dirk Schriefer,
  • Undine Proschmann,
  • Georges Katoul al Rahbani,
  • Tjalf Ziemssen and
  • Katja Akgün

27 February 2025

Disease-modifying therapies (DMTs) are known to impact cellular and humoral immune response in persons with multiple sclerosis (pwMS). In this study, we performed in-depth SARS-CoV-2-specific T-cell profiling using flow cytometry. T-cell immunity in...

  • Article
  • Open Access
1 Citations
2,152 Views
24 Pages

High-Throughput Sequencing Enables Rapid Analyses of Nematode Mitochondrial Genomes from an Environmental Sample

  • Akshita Jain,
  • Tongda Li,
  • John Wainer,
  • Jacqueline Edwards,
  • Brendan C. Rodoni and
  • Timothy I. Sawbridge

27 February 2025

Mitochondrial genomes serve as essential tools in evolutionary biology, phylogenetics, and population genetics due to their maternal inheritance, lack of recombination, and conserved structure. Traditional morphological methods for identifying nemato...

  • Article
  • Open Access
1,114 Views
12 Pages

27 February 2025

Anaplasma phagocytophilum, a tick-borne Rickettsiales, causes an emerging disease among humans and animals called granulocytic anaplasmosis. The organism expresses an immunodominant surface protein, MSP2/P44, that undergoes rapid antigenic variation...

  • Review
  • Open Access
2 Citations
7,717 Views
21 Pages

Latency Reversing Agents and the Road to an HIV Cure

  • Louis Tioka,
  • Rafael Ceña Diez,
  • Anders Sönnerborg and
  • Maarten A. A. van de Klundert

27 February 2025

HIV-1 infection cannot be cured due to the presence of HIV-1 latently infected cells. These cells do not produce the virus, but they can resume virus production at any time in the absence of antiretroviral therapy. Therefore, people living with HIV (...

  • Article
  • Open Access
1 Citations
1,469 Views
15 Pages

Genetic Diversity of Potential Drug Resistance Markers in Plasmodium vivax Isolates from Panama, Mesoamerica

  • Vanessa Vásquez,
  • Ana María Santamaría,
  • Dianik Moreno,
  • Fergie Ruíz,
  • Chystrie A. Rigg,
  • Luis F. Chaves and
  • José E. Calzada

27 February 2025

This study evaluated the genetic diversity and potential drug resistance markers in Plasmodium vivax isolates from Panama, a country in Mesoamerica, aiming to eliminate local malaria transmission. We analyzed 70 P. vivax samples collected between 200...

  • Article
  • Open Access
1 Citations
1,158 Views
18 Pages

Optimizing Clinical Management of COVID-19: A Predictive Model for Unvaccinated Patients Admitted to ICU

  • Ahmed Farhan,
  • Khouloud Ayed,
  • Sara Zayati,
  • Rym Akrout,
  • Akram Dlala,
  • Amal Abouda,
  • Nesrine Zoghlami,
  • Halima Mahjoubi,
  • Iheb Labbane and
  • Asma Gati

27 February 2025

This study investigates the impact of immunological and clinical factors on COVID-19 outcomes among unvaccinated individuals. A cohort of 42 unvaccinated patients admitted to an intensive care unit was analyzed, focusing on age, comorbidities, inflam...

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Pathogens - ISSN 2076-0817