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Pathogens, Volume 10, Issue 11

November 2021 - 178 articles

Cover Story: Parasitic helminths are master manipulators of host immunity. Their strategy is complex and involves the release of excreted/secreted products, including extracellular vesicles. Despite reports suggesting the importance of EV surface glycans in the interaction with target cells and thus subsequent effector functions, little is known about parasite EV glycomics. Interestingly, we found evidence of sialylation in Schistosoma mansoni EVs. This finding potentially highlights new means of immune evasion, as sialic acids play important roles in the context of infection but are not thought to be synthesized by helminths. Our results suggest the involvement of the tegument and the digestive and excretory systems in the release of EVs, supporting previous reports of EV diversity in trematodes. View this paper.
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Articles (178)

  • Article
  • Open Access
11 Citations
70,838 Views
18 Pages

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells

  • David A. Ostrov,
  • Andrew P. Bluhm,
  • Danmeng Li,
  • Juveriya Qamar Khan,
  • Megha Rohamare,
  • Karthic Rajamanickam,
  • Kalpana K. Bhanumathy,
  • Jocelyne Lew,
  • Darryl Falzarano and
  • Franco J. Vizeacoumar
  • + 6 authors

20 November 2021

(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interaction...

  • Systematic Review
  • Open Access
8 Citations
5,671 Views
14 Pages

20 November 2021

Nasal pathogen detection sensitivities can be as low as 70% despite advances in molecular diagnostics. This may be linked to the choice of sampling method. A diagnostic test accuracy review for sensitivity was undertaken to compare sensitivity of swa...

  • Article
  • Open Access
3 Citations
3,548 Views
16 Pages

Colistin Resistance Onset Strategies and Genomic Mosaicism in Clinical Acinetobacter baumannii Lineages

  • Viviana Cafiso,
  • Stefano Stracquadanio,
  • Veronica Dovere,
  • Flavia Lo Verde,
  • Alessandra Zega,
  • Giuseppe Pigola,
  • Simona Barnini,
  • Emilia Ghelardi and
  • Stefania Stefani

20 November 2021

The treatment of multidrug-resistant Gram-negative infections is based on colistin. As result, COL-resistance (COL-R) can develop and spread. In Acinetobacter baumannii, a crucial step is to understand COL-R onset and stability, still far to be eluci...

  • Review
  • Open Access
16 Citations
5,534 Views
26 Pages

Fighting HIV-1 Persistence: At the Crossroads of “Shoc-K and B-Lock”

  • Chiara Acchioni,
  • Enrico Palermo,
  • Silvia Sandini,
  • Marta Acchioni,
  • John Hiscott and
  • Marco Sgarbanti

20 November 2021

Despite the success of highly active antiretroviral therapy (HAART), integrated HIV-1 proviral DNA cannot be eradicated from an infected individual. HAART is not able to eliminate latently infected cells that remain invisible to the immune system. Vi...

  • Article
  • Open Access
21 Citations
4,017 Views
18 Pages

Dynamics of Neospora caninum-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme

  • Roberto Sánchez-Sánchez,
  • Ángela Vázquez-Calvo,
  • Mercedes Fernández-Escobar,
  • Javier Regidor-Cerrillo,
  • Julio Benavides,
  • Jorge Gutiérrez,
  • Daniel Gutiérrez-Expósito,
  • Francisco José Crespo-Ramos,
  • Luis Miguel Ortega-Mora and
  • Gema Álvarez-García

20 November 2021

Neospora caninum is an apicomplexan parasite that can cause abortions and perinatal mortality in sheep. Although ovine neosporosis has been described worldwide, there is a lack of information about the relationship between N. caninum serostatus and t...

  • Review
  • Open Access
16 Citations
3,925 Views
9 Pages

A Review of the Impact of the COVID-19 Pandemic on Colorectal Cancer Screening: Implications and Solutions

  • Suneha Sundaram,
  • Sean Olson,
  • Paranjay Sharma and
  • Shanmugarajah Rajendra

19 November 2021

The COVID-19 pandemic has impacted all aspects of medical care, including cancer screening and preventative measures. Colorectal cancer screening declined significantly at the onset of the pandemic as the result of an intentional effort to conserve r...

  • Review
  • Open Access
21 Citations
5,666 Views
16 Pages

19 November 2021

The yeast Saccharomyces cerevisiae has a remarkable ability to adapt its lifestyle to fluctuating or hostile environmental conditions. This adaptation most often involves morphological changes such as pseudofilaments, biofilm formation, or cell aggre...

  • Review
  • Open Access
16 Citations
5,477 Views
18 Pages

Methodologies for Generating Brain Organoids to Model Viral Pathogenesis in the CNS

  • Hannah K. Hopkins,
  • Elizabeth M. Traverse and
  • Kelli L. Barr

19 November 2021

(1) Background: The human brain is of interest in viral research because it is often the target of viruses. Neurological infections can result in consequences in the CNS, which can result in death or lifelong sequelae. Organoids modeling the CNS are...

  • Review
  • Open Access
13 Citations
5,027 Views
14 Pages

Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors

  • Hugo Aguilar-Díaz,
  • Rosa Estela Quiroz-Castañeda,
  • Karina Salazar-Morales,
  • Raquel Cossío-Bayúgar and
  • Estefan Miranda-Miranda

19 November 2021

Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide applic...

  • Article
  • Open Access
9 Citations
3,197 Views
16 Pages

Fox Serum Proteomics Analysis Suggests Host-Specific Responses to Angiostrongylus vasorum Infection in Canids

  • Nina Gillis-Germitsch,
  • Tobias Kockmann,
  • Christian M. O. Kapel,
  • Stig M. Thamsborg,
  • Pia Webster,
  • Lucienne Tritten and
  • Manuela Schnyder

19 November 2021

Dogs infected with the cardiopulmonary nematode Angiostrongylus vasorum may suffer from respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence. To evaluate the impact of infection on...

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Pathogens - ISSN 2076-0817