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Review

Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors

1
Unidad de Artropodología, Centro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad INIFAP, Jiutepec 62574, Mexico
2
Unidad de Anaplasmosis, Centro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad INIFAP, Jiutepec 62574, Mexico
3
Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico
*
Author to whom correspondence should be addressed.
The authors contributed equally as co-first authors.
Academic Editor: Mária Kazimírová
Pathogens 2021, 10(11), 1511; https://doi.org/10.3390/pathogens10111511
Received: 15 September 2021 / Revised: 1 November 2021 / Accepted: 16 November 2021 / Published: 19 November 2021
(This article belongs to the Special Issue Advances in the Immunobiology of Parasitic Diseases)
Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide application is a commonly used method with severe environmental consequences and the selection of tick-resistant populations. With these drawbacks, new tick control methods need to be developed, and the immune system of ticks contains a plethora of potential candidates for vaccine design. Additionally, tick immunity is based on an orchestrated action of humoral and cellular immune responses. Therefore, the actors of these responses are the object of our study in this review since they are new targets in anti-tick vaccine design. We present their role in the immune response that positions them as feasible targets that can be blocked, inhibited, interfered with, and overexpressed, and then elucidate a new method to control tick infestations through the development of vaccines. We also propose Extracellular Traps Formation (ETosis) in ticks as a process to eliminate their natural enemies and those pathogens they transmit (vectorial capacity), which results attractive since they are a source of acting molecules with potential use as vaccines. View Full-Text
Keywords: anti-tick vaccines; tick immune system; Rhipicephalus microplus; extracellular traps; Extracellular Traps Formation (ETosis); Neutrophils Extracellular Traps Formation (NETosis); cattle diseases anti-tick vaccines; tick immune system; Rhipicephalus microplus; extracellular traps; Extracellular Traps Formation (ETosis); Neutrophils Extracellular Traps Formation (NETosis); cattle diseases
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MDPI and ACS Style

Aguilar-Díaz, H.; Quiroz-Castañeda, R.E.; Salazar-Morales, K.; Cossío-Bayúgar, R.; Miranda-Miranda, E. Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors. Pathogens 2021, 10, 1511. https://doi.org/10.3390/pathogens10111511

AMA Style

Aguilar-Díaz H, Quiroz-Castañeda RE, Salazar-Morales K, Cossío-Bayúgar R, Miranda-Miranda E. Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors. Pathogens. 2021; 10(11):1511. https://doi.org/10.3390/pathogens10111511

Chicago/Turabian Style

Aguilar-Díaz, Hugo, Rosa E. Quiroz-Castañeda, Karina Salazar-Morales, Raquel Cossío-Bayúgar, and Estefan Miranda-Miranda. 2021. "Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors" Pathogens 10, no. 11: 1511. https://doi.org/10.3390/pathogens10111511

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