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The Interplay between Salmonella and Intestinal Innate Immune Cells in Chickens

Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Pretoria 0110, South Africa
Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University & Research, De Elst 1, 6708 PB Wageningen, The Netherlands
Author to whom correspondence should be addressed.
Academic Editor: Jaime Gómez-Laguna
Pathogens 2021, 10(11), 1512;
Received: 30 September 2021 / Revised: 15 November 2021 / Accepted: 15 November 2021 / Published: 19 November 2021
Salmonellosis is a common infection in poultry, which results in huge economic losses in the poultry industry. At the same time, Salmonella infections are a threat to public health, since contaminated poultry products can lead to zoonotic infections. Antibiotics as feed additives have proven to be an effective prophylactic option to control Salmonella infections, but due to resistance issues in humans and animals, the use of antimicrobials in food animals has been banned in Europe. Hence, there is an urgent need to look for alternative strategies that can protect poultry against Salmonella infections. One such alternative could be to strengthen the innate immune system in young chickens in order to prevent early life infections. This can be achieved by administration of immune modulating molecules that target innate immune cells, for example via feed, or by in-ovo applications. We aimed to review the innate immune system in the chicken intestine; the main site of Salmonella entrance, and its responsiveness to Salmonella infection. Identifying the most important players in the innate immune response in the intestine is a first step in designing targeted approaches for immune modulation. View Full-Text
Keywords: chicken; Salmonella; GALT; innate immune cells; intestine chicken; Salmonella; GALT; innate immune cells; intestine
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MDPI and ACS Style

Ijaz, A.; Veldhuizen, E.J.A.; Broere, F.; Rutten, V.P.M.G.; Jansen, C.A. The Interplay between Salmonella and Intestinal Innate Immune Cells in Chickens. Pathogens 2021, 10, 1512.

AMA Style

Ijaz A, Veldhuizen EJA, Broere F, Rutten VPMG, Jansen CA. The Interplay between Salmonella and Intestinal Innate Immune Cells in Chickens. Pathogens. 2021; 10(11):1512.

Chicago/Turabian Style

Ijaz, Adil, Edwin J.A. Veldhuizen, Femke Broere, Victor P.M.G. Rutten, and Christine A. Jansen. 2021. "The Interplay between Salmonella and Intestinal Innate Immune Cells in Chickens" Pathogens 10, no. 11: 1512.

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