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Diagnostics, Volume 15, Issue 18

September-2 2025 - 131 articles

Cover Story: Hepatic steatosis, or fatty liver, is a prevalent condition and an important precursor to cirrhosis and liver failure. Clinical diagnosis currently relies on invasive liver biopsy, as traditional computed tomography (CT) and simple attenuation thresholds lack the accuracy required to grade disease severity. Radiomics extracts high-dimensional quantitative features from medical images using mathematical formulas and enables fully automated characterization of subtle tissue patterns beyond human perception. In this study, we investigated whether CT radiomics combined with machine learning could predict histology-based steatosis severity in nonhuman primates. By identifying a radiomic signature of hepatic steatosis, our findings demonstrate the translational potential of this approach for non-invasive and objective diagnosis in humans. View this paper
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Articles (131)

  • Systematic Review
  • Open Access
701 Views
14 Pages

A Systematic Review of Optic Disc Drusen in the Modern Imaging Era: Structure–Function Correlates, Diagnostic Performance, and NAION Co-Occurrence

  • Alina Dumitriu,
  • Bogdan Dumitriu,
  • Flavius George Socol,
  • Ioana Denisa Socol,
  • Ionela Iasmina Yasar,
  • Camelia Fizedean,
  • Adelina Mavrea,
  • Andrei-Cristian Bondar and
  • Mihnea Munteanu

22 September 2025

Background and Objectives: Optic disc drusen (ODD) can mimic papilledema and are linked to structural crowding, microvascular change, and visual-field loss. We synthesized structural/microvascular differences, functional status and change, diagnostic...

  • Article
  • Open Access
1 Citations
673 Views
21 Pages

Cytokine Profiles as Predictive Biomarkers of Disease Severity and Progression in Engineered Stone Silicosis: A Machine Learning Approach

  • Daniel Sanchez-Morillo,
  • Ana Martín-Carrillo,
  • Blanca Priego-Torres,
  • Iris Sopo-Lambea,
  • Gema Jiménez-Gómez,
  • Antonio León-Jiménez and
  • Antonio Campos-Caro

22 September 2025

Background/Objectives: Silicosis caused by dust from engineered stone (ES) exposure is an emerging occupational lung disease that severely impacts respiratory health. This study aimed to analyze the association between cytokine profiles and disease s...

  • Article
  • Open Access
708 Views
14 Pages

The Contingency of Reported sST2 Serum Concentrations with a Protein Detection System (ELISA) from the Same Manufacturer (R&D Biotechne, 2002–2025): An Explanatory Effort by Applied Medical Researchers

  • Marie-Therese Lingitz,
  • Hannes Kühtreiber,
  • Lisa Auer,
  • Michael Mildner,
  • Bernhard Moser,
  • Christine Bekos,
  • Clemens Aigner,
  • Martin Direder,
  • Thomas Mueller and
  • Hendrik Jan Ankersmit

22 September 2025

Background/Objectives: Soluble ST2 (sST2) has gained recognition as a clinically relevant biomarker across a spectrum of inflammatory, cardiovascular, and respiratory conditions. However, the lack of assay standardization raises concerns about result...

  • Case Report
  • Open Access
904 Views
10 Pages

22 September 2025

Background/Objectives: Angioimmunoblastic T-cell lymphoma (AITL) is a rare peripheral T-cell lymphoma of follicular helper T-cell (TFH) origin, often associated with immune dysregulation and EBV-positive B-cell proliferation. Kaposi sarcoma (KS) is a...

  • Case Report
  • Open Access
1,018 Views
11 Pages

A Relapsed AML Case Featuring MYC and MECOM Rearrangements

  • Kevin A. Murgas,
  • Pons Materum,
  • Luke Z. Li,
  • Jacob Rocha,
  • Michael Schuster,
  • Tahmeena Ahmed and
  • Carlos A. Tirado

22 September 2025

Background/Objectives: Relapsed acute myeloid leukemia (AML) is often characterized by clonal evolution and acquired genomic abnormalities, which can inform prognosis and direct therapeutic decisions. The emergence of high-risk chromosomal rearrangem...

  • Article
  • Open Access
691 Views
17 Pages

Criteria and Protocol: Assessing Generative AI Efficacy in Perceiving EULAR 2019 Lupus Classification

  • Gerald H. Lushington,
  • Sandeep Nair,
  • Eldon R. Jupe,
  • Bernard Rubin and
  • Mohan Purushothaman

22 September 2025

Background/Objectives: In clinical informatics, the term ‘information overload’ is increasingly used to describe the operational impediments of excessive documentation. While electronic health records (EHRs) are growing in abundance, many...

  • Article
  • Open Access
918 Views
18 Pages

A Comparative Analysis of SegFormer, FabE-Net and VGG-UNet Models for the Segmentation of Neural Structures on Histological Sections

  • Igor Makarov,
  • Elena Koshevaya,
  • Alina Pechenina,
  • Galina Boyko,
  • Anna Starshinova,
  • Dmitry Kudlay,
  • Taiana Makarova and
  • Lubov Mitrofanova

22 September 2025

Background: Segmenting nerve fibres in histological images is a tricky job because of how much the tissue looks can change. Modern neural network architectures, including U-Net and transformers, demonstrate varying degrees of effectiveness in this ar...

  • Article
  • Open Access
1 Citations
883 Views
11 Pages

Cumulative Effect of Metabolic Factors on Hepatic Steatosis

  • Anna Egresi,
  • Brigitta Kozma,
  • Márton Karácsony,
  • Aladár Rónaszéki,
  • Klára Werling,
  • Barbara Csongrády,
  • Pál Kaposi Novák,
  • Anikó Folhoffer,
  • Attila Szijártó and
  • Krisztina Hagymási

22 September 2025

Background/Objectives: Hepatic steatosis, a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD), is closely associated with systemic metabolic dysfunction. However, the cumulative impact of metabolic risk factors on liver fat...

  • Article
  • Open Access
1,622 Views
14 Pages

22 September 2025

Objectives: This study aimed to evaluate the relationship between the median nerve cross-sectional area (CSA, mm2) and clinical findings, blood test results, and electrodiagnostic (EDX) measurements in patients with carpal tunnel syndrome (CTS). Meth...

  • Article
  • Open Access
1,101 Views
16 Pages

Impact of 68Ga-PSMA PET/MRI on the Accuracy of MRI-Derived Grading Systems for Predicting Extraprostatic Extension in Prostate Cancer

  • Lebriz Uslu-Beşli,
  • Selahattin Durmaz,
  • Aslıhan Onay,
  • Barış Bakır,
  • İclal Gürses,
  • Sevda Özel-Yıldız,
  • Çetin Demirdağ and
  • Haluk Burçak Sayman

22 September 2025

Objectives: Accurate preoperative staging and prediction of extraprostatic extension (EPE) are critical for optimal surgical planning in prostate cancer (PCa). This study evaluated the diagnostic accuracy of 68Ga-PSMA PET for EPE assessment, compared...

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Diagnostics - ISSN 2075-4418