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Diagnostics, Volume 12, Issue 1

January 2022 - 226 articles

Cover Story: Immune checkpoint inhibitors are monoclonal antibodies which unmask cancer to the immune system by blocking negative feedback signalling in T cells. These drugs have revolutionised cancer care and prolonged survival and increased cure rates in many malignancies. However, they are expensive, cause autoimmune toxicity and help only 40% of patients who receive them. The Healey Bird et al. review licensed tissue biomarkers of response and their limitations as well as emerging tissue, blood, and stool biomarkers which may help to predict both response and toxicity as a new generation of immune checkpoint inhibitors becomes available in cancer care. View this paper.
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Articles (226)

  • Article
  • Open Access
18 Citations
5,015 Views
11 Pages
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Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors

  • Núria Carreras-Dieguez,
  • Ariel Glickman,
  • Meritxell Munmany,
  • Georgina Casanovas,
  • Núria Agustí,
  • Berta Díaz-Feijoo,
  • Adela Saco,
  • Beatriz Sánchez,
  • Lydia Gaba and
  • Martina Aida Angeles
  • + 4 authors
Diagnostics2022, 12(1), 226;https://doi.org/10.3390/diagnostics12010226

17 January 2022

(1) OBJECTIVE: To assess the performance of CA125, HE4, ROMA index and CPH-I index to preoperatively identify epithelial ovarian cancer (EOC) or metastatic cancer in the ovary (MCO). (2) METHODS: single center retrospective study, including women wit...

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  • Article
  • Open Access
5 Citations
3,572 Views
15 Pages
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The Evaluation of the Four-Chamber Cardiac Dissection Method of the Fetal Heart as an Alternative to Conventional Inflow–Outflow Dissection in Small Gestational-Age Fetuses

  • Camelia Albu,
  • Adelina Staicu,
  • Roxana Popa-Stanilă,
  • Cosmina Bondor,
  • Bogdan Pop,
  • Liviu Chiriac,
  • Dan Gheban,
  • Romeo Micu,
  • Romulus Valeriu Flaviu Turcu and
  • Simion Simon
  • + 2 authors
Diagnostics2022, 12(1), 223;https://doi.org/10.3390/diagnostics12010223

17 January 2022

The examination of very small fetal hearts requires special equipment and a specialist that are not available in many general pathology laboratories. Compared to conventional examination, the four-chamber cardiac dissection (4CCD) method can be perfo...

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  • Article
  • Open Access
23 Citations
3,638 Views
14 Pages
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AI Denoising Significantly Improves Image Quality in Whole-Body Low-Dose Computed Tomography Staging

  • Andreas S. Brendlin,
  • David Plajer,
  • Maryanna Chaika,
  • Robin Wrazidlo,
  • Arne Estler,
  • Ilias Tsiflikas,
  • Christoph P. Artzner,
  • Saif Afat and
  • Malte N. Bongers
Diagnostics2022, 12(1), 225;https://doi.org/10.3390/diagnostics12010225

17 January 2022

(1) Background: To evaluate the effects of an AI-based denoising post-processing software solution in low-dose whole-body computer tomography (WBCT) stagings; (2) Methods: From 1 January 2019 to 1 January 2021, we retrospectively included biometrical...

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  • Article
  • Open Access
66 Citations
10,738 Views
11 Pages
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Artificial Intelligence Application in Assessment of Panoramic Radiographs

  • Łukasz Zadrożny,
  • Piotr Regulski,
  • Katarzyna Brus-Sawczuk,
  • Marta Czajkowska,
  • Laszlo Parkanyi,
  • Scott Ganz and
  • Eitan Mijiritsky
Diagnostics2022, 12(1), 224;https://doi.org/10.3390/diagnostics12010224

17 January 2022

The aim of this study was to assess the reliability of the artificial intelligence (AI) automatic evaluation of panoramic radiographs (PRs). Thirty PRs, covering at least six teeth with the possibility of assessing the marginal and apical periodontiu...

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  • Article
  • Open Access
16 Citations
4,599 Views
11 Pages
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Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics

  • Eun Ji Han,
  • Joo Hyun O,
  • Hyukjin Yoon,
  • Seunggyun Ha,
  • Ie Ryung Yoo,
  • Jae Won Min,
  • Joon-Il Choi,
  • Byung-Ock Choi,
  • Gyeongsin Park and
  • Han Hee Lee
  • + 3 authors
Diagnostics2022, 12(1), 222;https://doi.org/10.3390/diagnostics12010222

17 January 2022

Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and PET radiomic features, with BMBx results. A total of 328 patients were included; 269...

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  • Article
  • Open Access
12 Citations
3,404 Views
9 Pages
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Feasibility of Recombinant Human TSH as a Preparation for Radioiodine Therapy in Patients with Distant Metastases from Papillary Thyroid Cancer: Comparison of Long-Term Survival Outcomes with Thyroid Hormone Withdrawal

  • Hsi-Chen Tsai,
  • Kung-Chu Ho,
  • Shih-Hsin Chen,
  • Jing-Ren Tseng,
  • Lan-Yan Yang,
  • Kun-Ju Lin,
  • Ju-Chin Cheng and
  • Miaw-Jene Liou
Diagnostics2022, 12(1), 221;https://doi.org/10.3390/diagnostics12010221

17 January 2022

Background: this study was designed to compare the long-term survival outcomes of patients prepared for radioiodine (RAI) therapy using either thyroid hormone withdrawal (THW) or recombinant human thyrotropin (rhTSH) stimulation, by specifically focu...

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  • Article
  • Open Access
5 Citations
2,974 Views
8 Pages
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Immunohistochemical Expression Patterns of CD45RO, p105/p50, JAK3, TOX, and IL-17 in Early-Stage Mycosis Fungoides

  • Tariq N. Aladily,
  • Tasnim Abushunar,
  • Ahmad Alhesa,
  • Raneen Alrawi,
  • Noor Almaani and
  • Maram Abdaljaleel
Diagnostics2022, 12(1), 220;https://doi.org/10.3390/diagnostics12010220

17 January 2022

The morphologic changes in early-stage mycosis fungoides (MF) might overlap with benign inflammatory dermatitis (BID). Previous studies have described altered expression patterns of several proteins in MF, but their diagnostic significance is uncerta...

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  • Article
  • Open Access
3 Citations
2,666 Views
12 Pages
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Evaluation of Clinical and Immunohistochemical Factors Relating to Melanoma Metastasis: Potential Roles of Nestin and Fascin in Melanoma

  • Yumiko Yamamoto,
  • Yoshihiro Hayashi,
  • Hideyuki Sakaki and
  • Ichiro Murakami
Diagnostics2022, 12(1), 219;https://doi.org/10.3390/diagnostics12010219

17 January 2022

For melanoma treatment, an early diagnosis and a complete resection of the primary tumor is essential. In addition, detection of factors that may be related to metastasis is indispensable. A total of 30 Japanese patients with Stage I or II melanoma,...

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  • Article
  • Open Access
17 Citations
3,411 Views
19 Pages
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Sudden Cardiac Death and Ex-Situ Post-Mortem Cardiac Magnetic Resonance Imaging: A Morphological Study Based on Diagnostic Correlation Methodology

  • Giuseppe Bertozzi,
  • Francesco Pio Cafarelli,
  • Michela Ferrara,
  • Nicola Di Fazio,
  • Giuseppe Guglielmi,
  • Luigi Cipolloni,
  • Federico Manetti,
  • Raffaele La Russa and
  • Vittorio Fineschi
Diagnostics2022, 12(1), 218;https://doi.org/10.3390/diagnostics12010218

17 January 2022

During the last years, post-mortem imaging has gradually been assumed within research in the field of forensic pathology. This role appears to be clearly and simply applied in the trauma field with the use of conventional radiography or Post Mortem C...

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